Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common MarmosetPathogenesis and Immunity Published on 2021-12-152022-10-30 Journal: Journal of Virology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Callithrix jacchus Acquired acute respiratory syndrome aerosol route Aerosols animal animal model breathing difficulties Callithrix caused challenge characterized common complications Concentration coronavirus cough demonstrated described disease emerging disease England Erasmus Fatality rate Fever Host host response Human Immunological response individual interstitial pneumonia intranasal Lung disease lung tissue Macrophage macrophages marmoset medical countermeasure MERS-CoV Middle East Middle East respiratory syndrome Mild neutrophil function Neutrophils Pneumonia Pyrexia renal respiratory respiratory syndrome coronavirus route SARS-CoV-2 severity Shortness of breath strain syndrome the disease throat swab upregulation Viable virus were used [DOI] 10.1128/jvi.01739-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Nasally inhaled therapeutics and vaccination for COVID‐19: Developments and challengesReview Published on 2021-12-142022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ACE2 addition administration Antiviral clearance COVID‐19 COVID‐19 management develop development Effect effective effective delivery Efficacy enzyme evade examined Factor Inhaled inhaled vaccine initial intramuscular vaccination intranasal lactobacillus management medication Medicines modifications Mucociliary clearance nasal Nasal spray physiological Region Replication SARS‐CoV‐2 Therapies translocation Transmission vaccination Vaccine Variability variant viral entry viral infection [DOI] 10.1002/mco2.101 PMC 바로가기 [Article Type] Review
Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2Research Published on 2021-12-082022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Administered airway approach approved Complete COVID-19 COVID-19 pandemic COVID-19 vaccine death effective vaccine Emergency use hACE2 HD-Ad Human Immunity immunization Infection Intramuscular injection intranasal intranasally K18-hACE2 mice Lower respiratory tract mice mucosal nasal delivery platform Prevent prime-boost regimen PROTECT RBD Receptor binding domain recorded Result robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 secreted Spike protein supplementary material the SARS-CoV-2 upper respiratory tract Vaccine variants Viral transmission [DOI] 10.1186/s13578-021-00723-0 PMC 바로가기 [Article Type] Research
A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters생약독화 파라인플루엔자 바이러스 매개 SARS-CoV-2 백신의 단일 비강 투여는 햄스터를 보호합니다423 Published on 2021-12-072022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, SARS, 진단, [키워드] age all age groups antibody Antigen B.1.1.7 B.1.351 children chimeric clinical evaluation contribute COVID-19 dose effort evaluated exhibited Express expressed expressing expression fold generally mild hamster hamsters IgA IgG immunization immunogenic Infant Infants intranasal intranasal immunization intranasally Lineage lineages lung Lungs manuscript moderate morbidity nasal tissue neutralization Neutralizing activity parainfluenza parainfluenza virus parainfluenza virus 3 parainfluenza virus vaccines pediatric prefusion PROTECT Protective Receptor binding domain replicated Replication respiratory tract restrict robust S protein S-2P SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines serum Significance significantly higher Single-dose Spike protein TCID the SARS-CoV-2 titers Transmission dynamics undetectable Vaccine vaccine candidate vaccine vector vector vectors virus was reduced weight loss [DOI] 10.1073/pnas.2109744118 PMC 바로가기 [Article Type] 423
High-Yield Production of Receptor Binding Domain of SARS-CoV-2 Linked to Bacterial Flagellin in Plants Using Self-Replicating Viral Vector pEffArticle Published on 2021-12-062022-10-28 Journal: Plants [Category] COVID-19, [키워드] conditions coronavirus COVID-19 COVID-19 pandemic cytosol denaturing dialysis expressed expression flagellin fraction fused fusion protein Genome insoluble intranasal mucosal Ni-NTA Nicotiana benthamiana plant plants Production Protein purification purified RBD reached Receptor binding domain recombinant vaccine remained reported required Salmonella Typhimurium SARS-CoV-2 SARS-CoV-2 spike glycoprotein tissue Vaccine vector virus [DOI] 10.3390/plants10122682 PMC 바로가기 [Article Type] Article
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)Research Article Published on 2021-12-012022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] B.1 B.1.1.28.1 B.1.1.7 B.1.351 B.1.617.2 Beta caused Complete COVID-19 pandemic cross-neutralizing antibody response Delta description disease Efficacy elicited evade Gamma hamster Infection intranasal offered PROTECT Protective provide SARS-CoV-2 SARS-CoV-2 variant susceptible the SARS-CoV-2 genome vaccination Vaccine vaccine candidate variants of concern virus VoC [DOI] 10.1126/sciadv.abk0172 PMC 바로가기 [Article Type] Research Article
Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies전임상 연구에서 코로나19 불활화 백신(CoviVac)의 장기 체액성 면역원성, 안전성 및 보호 효능Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 신약개발, 진단, [키워드] allergenic animal model animal models anti-SARS-CoV-2 IgG clinical trial clinical trials country Course COVID-19 COVID-19 pandemic decrease demonstrated Effects Efficacy hamster hamsters humoral immune response humoral immunogenicity immune response immunization immunogenicity implementation inactivated Inactivated vaccine intranasal Live virus mice multitude NAb NAbs Neutralizing Neutralizing antibodies non-human primates preclinical study Protective reproductive robust robustness rodent rodents Safety SARS-CoV-2 severe pneumonia significantly stability teratogenic teratogenic effects the vaccine the vaccines These data Toxicity Vaccine vaccine platform virion [DOI] 10.1080/22221751.2021.1971569 PMC 바로가기 [Article Type] Article
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike proteinSARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.Article Published on 2021-12-012022-09-11 Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘, [키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased [DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article
Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus InfectionArticle Published on 2021-11-282022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACSL1 administration ameliorated Apoptosis approach C57BL/6 caused Cell coronavirus Coronavirus infection expression Ferroptosis Genes Hepatitis Host hyper-inflammation in vivo indicate induce inducer infected cells Infection Inflammatory cytokine inhibited inhibitor intranasal involved Lung inflammation lytic cell death Macrophage macrophages MHV-A59 mice mouse hepatitis virus (MHV) murine necroptosis pathogenicity performed Potential treatment PROTECT pyroptosis released RNA-Seq shown suppressed Syncytia syncytia formation targeting therapy tissue injury TLR4 upregulate upregulation viral propagation virus strain [DOI] 10.3390/v13122383 PMC 바로가기 [Article Type] Article
Persistent Parosmia Caused By COVID-19 Infection: An Emerging SymptomOtolaryngology Published on 2021-11-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] age Anosmia Arabic clinical feature clinics collected Coronavirus disease 2019 Course COVID-19 COVID-19 illness effective eight evaluate female full recovery hospital Intervention intranasal introduced management objective olfactory olfactory dysfunction outcome pandemic era parosmia Patient persistent post-COVID-19 patient protocols ranged receive reported Result severity Steroids Symptom Symptoms symptoms of COVID-19 taste dysfunction tertiary care hospital Test the patient Treatment was used [DOI] 10.7759/cureus.19921 PMC 바로가기 [Article Type] Otolaryngology