Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective studyObservational Study Published on 2021-06-012022-10-04 Journal: Internal and Emergency Medicine [Category] 임상, [키워드] airway analyzed case sery Characteristics clinical Clinical course cohort of patient consecutive patients Continuous COVID-19 COVID-19 patients CPAP CPAP (continuous positive airway pressure) diagnosed discharged discharged home DNI Emergency Epidemiology high mortality rate Hospitalization Intubated Italy lombardy mechanical ventilation mortality rate NIV NIV (non-invasive ventilation) Non-invasive occurred outbreak outcome overall mortality oxygen oxygen only oxygen support Patient patients patients died patients treated Pneumonia poor prognosis positive pressure Respiratory Coronavirus Respiratory Support retrospective Retrospective study room SARS-CoV-2 SARS-COV-2 infection severe respiratory failure single-center Support therapy threshold Throughout the study treated Treatment ventilator with COVID-19 [DOI] 10.1007/s11739-020-02548-0 PMC 바로가기 [Article Type] Observational Study
Should COVID-19 patients >75 years be Ventilated? An Outcome StudyObservational Study Published on 2021-05-192022-10-05 Journal: QJM: An International Journal of Medicine [Category] SARS, 임상, [키워드] adverse outcomes age cardiovascular comorbidity Characteristics cohort study COVID-19 patient Critical Critical disease current Dementia diarrhea disease elderly Factor Frequency group highest Hospitalized in-hospital mortality increased risk Intubated intubation Mortality outcome Oxygen requirements Patient patients with COVID-19 presenting Primary outcome required severity significant difference significantly Symptom the patient Vasopressor with COVID-19 [DOI] 10.1093/qjmed/hcab029 PMC 바로가기 [Article Type] Observational Study
Unexplained worsening of parkinsonian symptoms in a patient with advanced Parkinson’s disease as the sole initial presentation of COVID-19 infection: a case reportCase Report Published on 2021-05-172022-10-31 Journal: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery [Category] COVID-19, [키워드] absence acute respiratory syndrome association Case report Confusion coronavirus coronavirus disease COVID-19 COVID-19 infection Dyspnea feature Features Fever initial Intubated knowledge male Nasopharyngeal swab neurodegenerative Neurological complication pandemic Parkinson’s disease Parkinson’s disease parkinsonian Parkinsonism Patient positive progressed reported respiratory symptoms rigidity SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms tested viral infection worsening [DOI] 10.1186/s41983-021-00314-3 PMC 바로가기 [Article Type] Case Report
Clinical features and prognostic factors in Covid-19: A prospective cohort studyCovid-19의 임상 특징 및 예후 요인: 전향적 코호트 연구Multicenter Study Published on 2021-05-142022-08-31 Journal: EBioMedicine [Category] 바이오마커, [키워드] Adhesion Molecule Admission Analysis Angiogenesis angiopoietin association Biomarker Blood CD14 cell adhesion molecule cell-cell adhesion changes in chemotaxis clinical Clinical deterioration Clinical features Coagulation Cohort complement complement component complement system Concentration Corona Corticosteroids COVID-19 COVID-19 infection Cox regression death Deterioration died Disease progression driven by End end products Endothelial dysfunction feature fibrinolysis finding funding Glycation group hospitalized patient hospitalized patients host response ICU ICU Patients IL-1-receptor IL-10 IL-6 IL-8 immunothrombosis Inflammation insight interleukin Intubated involved joint lactoferrin lead life cycle linear marker mechanisms mixed-effects models Mortality multiple pathways Necrosis outcome overlap pathway Pathway analysis Pathways Patient patients died patients with COVID-19 performed Primary outcome procalcitonin product Prognosis Prognostic factor Prognostic markers prospective cohort study receptor receptor antagonist Regulation risk severe COVID-19 therapy tissue tissue damage Tissue Factor transferred Treatment strategies Tumor tumor necrosis tumor necrosis factor urokinase Urokinase-Type Plasminogen Activator variety vascular cell adhesion VCAM-1 Viral viral life cycle ward with COVID-19 wound healing [DOI] 10.1016/j.ebiom.2021.103378 PMC 바로가기 [Article Type] Multicenter Study
Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study Prognosis of COVID-19 elderly critically ill patients in the ICUResearch Published on 2021-05-142022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory distress syndrome Admission age Analysis cardiovascular dysfunction Care chronic respiratory disease clinical Cohort Comorbidity COVID-19 COVID-19 pandemic Critically ill Critically ill patient database diabete diabetics Elderly patient evaluated first symptom First wave frailty Future hazard ratio Health hypertension ICU ICU admission intensive care intensive care unit International Intubated intubation management median Mortality Old patients older patient older patients outcome PaO Patient patients older Prognosis reached reported resources Result scale significantly higher supplementary material with COVID-19 [DOI] 10.1186/s13613-021-00861-1 PMC 바로가기 [Article Type] Research
Repurposing existing medications for coronavirus disease 2019: protocol for a rapid and living systematic review2019년 코로나바이러스 질병에 대한 기존 약물 용도 변경: 신속하고 생생한 체계적 검토를 위한 프로토콜Protocol Published on 2021-05-072022-09-10 Journal: Systematic Reviews [Category] SARS, 신약개발, [키워드] acute respiratory syndrome Clinical data Clinical improvement Clinical studies clinical study clinicians and researchers Compound coronavirus disease Coronavirus disease 2019 COVID-19 database drug Efficacy effort Evidence group Hospital stay in vitro include intensive care intensive care unit Intubated list medication MERS-CoV methodology middle Middle East respiratory syndrome Coronavirus Middle Eastern Respiratory Syndrome Mortality proportion proportions protocol Repurposed repurposing Research respiratory SARS SARS-CoV2 Severe acute respiratory syndrome supplementary material sustained syndrome systematic review transferred Viral viral clearance [DOI] 10.1186/s13643-021-01693-7 PMC 바로가기 [Article Type] Protocol
Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial급성 COVID-19 호흡기 질환이 있는 성인을 위한 회복기 혈장(CONCOR-1): 국제, 다기관, 무작위 배정, 공개 시험을 위한 연구 프로토콜Study Protocol Published on 2021-05-042022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome Analysis anti-SARS-CoV-2 antibodies antibodies antibody titres baseline Blood Group CCP Community community acquired community acquired pneumonia CONCOR-1 convalescent plasma coronavirus COVID-19 COVID-19 infection criteria death detect detectable anti-SARS-CoV-2 antibodies detectable anti-SARS-CoV-2 antibody determine Donor donors Ebola Ebola virus Efficacy and safety estimation Evidence exclusion criteria Exploratory analyses global pandemic hospital include inclusion criteria independent Infection Influenza information intensive care interim analysis International Intubated intubation Middle East Middle East respiratory syndrome multicentre NCT04348656 Neutralization assay neutralization assays Non-intubated Novel coronavirus Open-label outcome oxygen Patient patients with SARS-CoV-2 plasma Pneumonia Primary outcome quantified randomization Randomized Randomized controlled trial randomized trial reaction receive receiving recruitment reduce reduction in Relative risk respiratory respiratory complication Respiratory complications Respiratory illness respiratory symptom respiratory symptoms responsible risk risk reduction Sample size SARS-CoV-2 SARS-CoV-2 antibody titre SARS-CoV-2 antibody titres SARS-COV-2 infection SARS-CoV-2 viral load secondary Secondary outcomes Serious Adverse Events Serologically Severe acute respiratory syndrome Standard of care Study protocol supplemental oxygen Support syndrome threshold thresholds titre transfusion reactions Trial two-sided Ventilator-free days Viral viral disease Viral diseases Viral load with COVID-19 [DOI] 10.1186/s13063-021-05235-3 PMC 바로가기 [Article Type] Study Protocol
Non-invasive positive pressure ventilation versus endotracheal intubation in treatment of COVID-19 patients requiring ventilatory supportResearch article Published on 2021-05-012022-10-05 Journal: The American journal of emergency medicine [Category] SARS, 치료법, [키워드] 30-Day mortality 95%CI age all-cause mortality Analysis benefit Brooklyn Comorbidities Confidence intervals COVID-19 COVID-19 confirmed patient COVID-19 patient Endotracheal intubation enrolled exposure greater hospital hospitalized COVID-19 patient Hypoxemia Importance initial interquartile ranges Intervention Intubated intubation lower mortality median Mortality mortality rate multivariable analysis multivariable logistic regression multivariable model New York City NIV non-invasive positive pressure ventilation non-invasive ventilation objective Odds ratio outcome oxygen saturation participant Patient patients percentage positive pressure ventilation presenting qSOFA Relevance required Respiratory failure Result secondary setting Sex Support survival Treatment undergo utilization variables ventilator ventilatory support [DOI] 10.1016/j.ajem.2021.01.068 [Article Type] Research article
Acute inflammatory demyelinating polyneuropathy or Guillain-Barré syndrome associated with COVID-19: a case reportCase Report Published on 2021-04-282022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, [키워드] administration Anosmia Asymptomatic bilateral pulmonary infiltrate Case report characterized common complications of COVID-19 Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 infection COVID-19 patients Cytokine storm described diagnosed disease distress Evidence FIVE global pandemic Guillain-Barré syndrome headache Immunoglobulin include Infection Inflammatory inflammatory markers intravenous Intubated intubation Mild Neurological complication physical physician remained reported Respiratory failure severity syndrome the patient The United States therapy transferred Treatment weakness with COVID-19 worsening [DOI] 10.1186/s13256-021-02831-4 PMC 바로가기 [Article Type] Case Report
The Clinical Course of Coronavirus Disease 2019 in a US Hospital System: A Multistate AnalysisAcademicSubjects/MED00860 Published on 2021-04-222022-10-27 Journal: American journal of epidemiology [Category] COVID-19, [키워드] 95% confidence interval Admission age-stratified mortality Analysis black clinical Clinical course coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalizations death died discharge discharged granular Health hospital Hospitalization Hospitalized IMV information intensive care intensive care unit interquartile range Intubated Invasive mechanical ventilation laboratory-confirmed longitudinal trajectory mechanical ventilation median age multistate analysis offer outcome Patient peaked performed public health receiving remained risk with COVID-19 [DOI] 10.1093/aje/kwaa286 PMC 바로가기 [Article Type] AcademicSubjects/MED00860