Excellent option for mass testing during the SARS-CoV-2 pandemic: painless self-collection and direct RT-qPCRSARS-CoV-2 대유행 중 대량 테스트를 위한 탁월한 옵션: 고통 없는 자가 수집 및 직접 RT-qPCRShort Report Published on 2021-05-042022-09-01 Journal: Virology Journal [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed approach assistance Asymptomatic classic coronavirus COVID-19 Ct values cycle threshold followed by healthcare personnel investigated isolate isolates Mass molecular testing Nasal mid-turbinate swab nasal swab nasal swabs Nasopharyngeal swab nasopharyngeal swabs Negative predictive value no symptoms pandemic PCR PCR diagnostics performed positive Post-pandemic era predictive values prospective cohort study Research respiratory RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 pandemic self-collection severe acute respiratory syndrome Coronavirus subject subjects tested the disease the SARS-CoV-2 Viraemia Viral Viral load [DOI] 10.1186/s12985-021-01567-3 PMC 바로가기 [Article Type] Short Report
Global and local mutations in Bangladeshi SARS-CoV-2 genomes방글라데시 SARS-CoV-2 게놈의 글로벌 및 로컬 돌연변이Article Published on 2021-05-012022-09-11 Journal: Virus research [Category] SARS, 변종, [키워드] acute respiratory syndrome Amino acid amino acid change Analysis average Bangladesh circulating clade coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 D614G D614G mutation Deletion deletions Epidemiology European G614 variant Genome genomes indicated insertion isolates Local Missense mutations Mutation mutations ORF1 ORF1ab ORF3a Pathogenesis phylogenetic analyses predominant prevalent protein level protein levels reported respiratory RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequences SARS-CoV-2 virus SARS-CoV-2 viruses sequence sequences Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly higher spike glycoprotein synonymous transmitted unique Variation variations viruses whole genome whole genomes Whole-genome sequence [DOI] 10.1016/j.virusres.2021.198390 PMC 바로가기 [Article Type] Article
Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virusResearch Article Published on 2021-04-292022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] activities activity Analysis antiviral activity broad-spectrum antivirals cholesterol Combined coronavirus COVID-19 CoVs Critical exhibited fusion inhibitor HIV-1 HIV-2 human coronavirus Infection information inhibited inhibitor inhibitors inhibitory activity isolates lipopeptide mechanism membrane fusion molecular docking mutant outbreak peptide provide reported SARS-CoV-2 sequence significantly simian immunodeficiency virus SIV [DOI] 10.1080/22221751.2021.1917309 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formationSARS-CoV-2는 바이러스 진입 및 병리학적 합포체 형성을 위해 콜레스테롤을 필요로 합니다Research Article Published on 2021-04-232022-09-10 Journal: eLife [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 approaches caused Cell Cell Biology cell-cell fusion cell-cell fusion assay cholesterol co-culture Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients Culture drug expressing facilitate Host immune response Human human cell human cells identify induce intercellular intercellular contacts isolates lung Lungs mechanism membrane membrane fusion membrane fusion event membrane fusion events Microscopy molecular basis multinucleated cell multinucleated cells outcome positive producing Quantitative receptor ACE2 regions Replication replication-competent SARS-CoV-2 reported reveal SARS-CoV-2 SARS-CoV-2 spike Screen spike spike variants statins Syncytia syncytia formation Therapeutics thought Viral viral entry virus viruses [DOI] 10.7554/eLife.65962 PMC 바로가기 [Article Type] Research Article
Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza virusesArticle Published on 2021-04-222022-10-04 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 치료제, [키워드] ACE2 acute respiratory syndrome addition Analysis angiotensin-converting enzyme 2 Antimicrobials Antiviral agents binding block viral entry characterized clade Concentration coronavirus Cytopathic effect demonstrated Effect effective Efficacy H1N1 H5N1 in vitro Influenza virus influenza viruses inhibit inhibited inhibiting interfere isolates nanoparticle Nanoparticles opportunistic Infections Prevent Prophylactic receptor reduced SARS-CoV-2 SARS-CoV-2 spike protein scattering shown syncytium formation transmission electron microscopy viral infection virus wild-type [DOI] 10.1038/s41598-021-87254-3 PMC 바로가기 [Article Type] Article
Risk Factors for Mortality in Adult COVID-19 Patients Who Develop Bloodstream Infections Mostly Caused by Antimicrobial-Resistant Organisms: Analysis at a Large Teaching Hospital in ItalyArticle Published on 2021-04-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI age Analysis antimicrobial resistance Antimicrobial therapy association Blood bloodstream bloodstream infection BSI Candida clinically conducted COVID-19 COVID-19 patient Cox regression Culture death develop died discharge Enterococcus Factor help hospital Hospital admission in-hospital mortality inclusion criteria Infection isolates Italy Kaplan–Meier Mortality multidrug-resistant occurred organism Organisms outcome Patient patients patients with COVID-19 performed Pseudomonas aeruginosa reduce retrospective risk factor Risk factors SARS-COV-2 infection Septic shock Staphylococcus aureus survival survived Teaching variable were infected while [DOI] 10.3390/jcm10081752 PMC 바로가기 [Article Type] Article
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir전 세계적으로 순환하는 분리주와 최근에 출현한 인간과 밍크 변이체에서 SARS-CoV-2 RNA 복제 복합체의 유전적 보존은 렘데시비르에 대한 최소한의 기존 내성을 시사합니다Article Published on 2021-04-012022-09-11 Journal: Antiviral Research [Category] SARS, 변종, 유전자 메커니즘, [키워드] active site addition Amino acid amino acid substitution analyzed antiviral activity approved circulating complex coronavirus COVID-19 Critical Efficacy exhibit Frequency Genetic genetic diversity Genetic variation highest Human in vitro isolate isolates mechanism molecular target Mutation nsp10 Nsp12 nsp12 RdRp. nsp13 nsp14 Nsp7 NSP8 P323L polymerase RdRP RDV Remdesivir Replication resistance risk RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequence variation sequences South Africa Spread stability Treatment treatment of COVID-19 United Kingdom variant variants virus [DOI] 10.1016/j.antiviral.2021.105033 PMC 바로가기 [Article Type] Article
UMAP-assisted K-means clustering of large-scale SARS-CoV-2 mutation datasets대규모 SARS-CoV-2 돌연변이 데이터 세트의 UMAP 지원 K-평균 클러스터링Article Published on 2021-04-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused Clustering combating controlling coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset datasets Effectiveness Evolution growth IMPROVE increasingly isolate isolates K-means clustering mutations PCA Phylogenetic analysis Principal component principal component analysis projection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 mutation severe acute respiratory syndrome Coronavirus t-SNE. transmission of SARS-CoV-2 UMAP understanding unique [DOI] 10.1016/j.compbiomed.2021.104264 PMC 바로가기 [Article Type] Article
Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike proteinResearch Article Published on 2021-03-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] ACE ACE2 Analysis antibodies antibody Belgium binding binding domain circulating clades Comparative genomics Consensus country COVID-19 D614G docking enzyme expected EY6A Fatality rate France Genome higher affinity higher fatality rate higher infectivity India infection rates Interaction isolate isolates Italy lowest Molecular dynamics simulation mortality rate Mutation N439K Neutralizing antibodies neutralizing monoclonal antibodies novel coronavirus SARS-CoV-2 pandemic Pathogenesis Prevalence prevalent RBM reactivity receptor Receptor binding domain receptor binding motif reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus Spike protein Support USA variant virulence Wuhan-1 [DOI] 10.1016/j.heliyon.2021.e06564 PMC 바로가기 [Article Type] Research Article
Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriaeArticle Published on 2021-03-082022-10-04 Journal: Nature Communications [Category] 변종, [키워드] analysed Antibiotic resistance Bacterial evolution Bacterial genomics bacterial toxins breadth caused clade Cluster core gene Corynebacterium diphtheriae country determine Diphtheria generate Genome genomic variation greater increase in isolate isolates Isolation medium Mutation Numerous Pathogens persistence Phylogeny Region resistance gene resistance genes Respiratory disease the disease toxin Vaccine variants Variation [DOI] 10.1038/s41467-021-21870-5 PMC 바로가기 [Article Type] Article