The Use of Antiviral Agents against SARS-CoV-2: Ineffective or Time and Age Dependent Result? A Retrospective, Observational Study among COVID-19 Older Adults †Article Published on 2021-02-102022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome administration affected age agent Analysis analyzed Antiviral antiviral activity Antiviral treatment antivirals association center clinical coronavirus coronavirus disease cough COVID-19 COVID-19 patient darunavir/cobicistat demonstrated Department Dependent drug Drug administration Dyspnea Emergency geriatric Gerontology HCQ Hydroxychloroquine in-hospital mortality Ineffective Italy logistic regression model Lopinavir/ritonavir lower mortality Mortality mortality rate Multivariate analysis no difference Older Older age Patient predictor presenting primary symptom regimen SARS-CoV-2 Support survival survival analysis Symptom symptoms onset the timing time Timing treated Treatment was performed [DOI] 10.3390/jcm10040686 PMC 바로가기 [Article Type] Article
Effectiveness and safety of intravenous tocilizumab to treat COVID-19-associated hyperinflammatory syndrome: Covizumab-6 observational cohortCOVID-19 관련 과염증 증후군 치료를 위한 정맥 토실리주맙의 효과 및 안전성: Covizumab-6 관찰 코호트Observational Study Published on 2021-02-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 임상, 진단, [키워드] acute lung injury acute phase reactants administration antagonist ARDS Cohort complications COVID-19 COVID-19 patient Critical Cytokine release syndrome distress effective Efficacy and safety ferritin Hospitalized hospitalized patient Hyperinflammatory ICU admission IL-6 IL-6R IL-6R antagonist Infection Inflammatory response intravenous tocilizumab liver lower mortality Mortality mortality rate observé Patient patients with COVID-19 Prevent Proteins Safe SARS-CoV-2 Standard of care syndrome TCZ Tocilizumab treat treated Treatment viral infection [DOI] 10.1016/j.clim.2020.108631 PMC 바로가기 [Article Type] Observational Study
A review of the genome, epidemiology, clinical features, prevention, and treatment scenario of COVID-19: Bangladesh aspectsReviews Published on 2021-01-292022-10-31 Journal: The Egyptian Journal of Bronchology [Category] COVID-19, [키워드] acute respiratory disease age Bangladesh aspects candidate vaccine caused China clinical feature Clinical features clinical trial coronavirus country COVID-19 COVID-19 patient death Deceased development Diagnosis dry cough economic impact Epidemiology European fatigue female Fever Gender Genome Haplotype Health healthcare facility highest homology immune system implicated IMPROVE Incubation period individual Isolation lockdown lower mortality mortality rate ORF1ab gene pandemic Patient patients Phylogenetic analysis prevalent preventive measure promote quarantine reflect SARS-CoV-2 sequence single-nucleotide Sinovac social distancing susceptible the N protein Treatment Vaccine development variant variants virus virus strain [DOI] 10.1186/s43168-021-00053-2 PMC 바로가기 [Article Type] Reviews
Higher comorbidities and early death in hospitalized African-American patients with Covid-19Research Article Published on 2021-01-182022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] ACE ACE inhibitor ACE inhibitors Admission African-Americans Analysis angiotensin II receptor blockers ARBs benefit black body mass index Care cause Chronic kidney disease clinical feature Comorbidities Comorbidity consecutive patient Coronary artery disease COVID-19 COVID-19 patient Cox proportional hazard Critical CRP death demonstrated determine Diabetes Mellitus dialysis died Efficacy Escalation favorable effect Glucose groups Health Health disparities Hemodialysis Hospitalization Hospitalized identify in-hospital mortality independent predictor Inpatient Invasive mechanical ventilation Laboratory laboratory data LDH lower mortality majority morbidity and mortality Mortality New York City outcome outcomes pandemic Patient patients performed positive Predictive Prevalence procalcitonin prognostic Racial receive required Result retrospective cohort study significantly suffered supplementary material tested The United States treatment interventions was performed [DOI] 10.1186/s12879-021-05782-9 PMC 바로가기 [Article Type] Research Article
The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish HospitalsArticle Published on 2021-01-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019-nCoV 95% CI acute respiratory distress age all-cause mortality analysed Analysis Blood blood cell counts carried Cell Cohort cohort study confounders coronavirus coronavirus 2 Course COVID-19 death decrease described determine eosinophil eosinophils examined hospital hospitalisation hospitalised hospitalised patient ICU admission increase in independent Inhaled internal knowledge lower mortality lymphocyte main outcome measure male Mortality multicentre outcome Patient patients with COVID-19 predictor Prognosis Prognostic value registry required respiratory retrospective SARS-CoV-2 Society Spain Spanish syndrome systemic glucocorticoid value was performed with COVID-19 [DOI] 10.3390/jcm10020305 PMC 바로가기 [Article Type] Article
More skilled clinical management of COVID-19 patients modified mortality in an intermediate respiratory intensive care unit in ItalyObservational Study Published on 2021-01-152022-10-04 Journal: Respiratory Research [Category] MERS, 임상, [키워드] acute respiratory syndrome Admission assisted ventilation average Care clinical feature Clinical management clinical setting coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical care died epidemiological Follow-up hospital Hospitalized hospitalized patient ICU intensive care intensive care unit Intermediate RICU investigated Italy laboratory-confirmed lower mortality modify Mortality pandemic Patient patients who survived reported respiratory Result retrospective SARS-CoV-2 significantly suggested survival survived the patient transferred two group virus [DOI] 10.1186/s12931-021-01613-2 PMC 바로가기 [Article Type] Observational Study
Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and DiabetesEndocrinology Published on 2021-01-132022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] 95% CI African-American age analyzed approach association Care Characteristics Comorbidity conducted coronavirus disease-2019 COVID-19 Data analysis death diabete diabetes diagnosis of COVID-19 dramatic increase Health high risk hypertension independent risk factor linear Logistic regression lower mortality metformin Mortality obesity Odds ratio pandemic Population Primary outcome Protective Racial raising reduced reduction in mortality Result retrospective risk Sex subject tested Treatment university [DOI] 10.3389/fendo.2020.600439 PMC 바로가기 [Article Type] Endocrinology
Anti-IL6 treatment of serious COVID-19 disease A monocentric retrospective experience심각한 COVID-19 질병의 항IL6 치료 단일 중심적 후향적 경험4900 Published on 2021-01-082022-09-12 Journal: Medicine [Category] 진단, [키워드] acting Acute myocardial infarction acute respiratory distress acute respiratory distress syndrome anti-cytokine anti-IL6 ARDS candidate Candidates clinical trial collected data Complication complications control group coronavirus counterproductive COVID-19 COVID-19 pneumonia cytokine determine died discharged disease drug effective eligible event form framework help Hospitalization Hospitalized identify IL6 Infectious complications Inflammation intensive care interleukin-6 Intervention intravenously Intubated lower mortality medium Mortality multi-organ failure Patient Pneumonia Prognosis Pulmonary thromboembolism reducing respiratory complication Respiratory complications respiratory distress Respiratory failure retrospective risk sarilumab serious COVID-19 severe acute respiratory distress syndrome severe respiratory failure single center Standard of care suffered syndrome systemic level Therapies Thromboembolism Tocilizumab treated Treatment [DOI] 10.1097/MD.0000000000023582 PMC 바로가기 [Article Type] 4900
Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in ChinaCOVID-19 환자의 질병 진행에 대한 조기 산소 요법 및 항바이러스 치료의 효과: 중국의 의료 차트에 대한 후향적 연구Research Article Published on 2021-01-062022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] MERS, 치료제, [키워드] 95%CI antiviral drug antiviral drugs Antiviral treatment carried China clinical feature Clinical features coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality Critical Critical illness critical patients Critically ill Critically ill patient critically ill patients described Disease progression Effect effective Effectiveness Evidence expand exploratory groups hospital hospitalized patient hospitalized patients Hypoxemia hypoxia identify IFNα Infection Initiation less lower mortality lower risk medical intervention Medical resources Mild multivariable analyses oxygen Oxygen therapy Oxygen treatment pandemic Patient patients Prevalence recommendation retrospective retrospective review Retrospective study risk factor Risk factors risk of death seeking severe disease severity significantly significantly higher Support Symptom symptom onset symptomatic Symptoms symptoms onset the patient the timing these symptom these symptoms Tongji Hospital treated with COVID-19 Wuhan [DOI] 10.1371/journal.pntd.0009051 PMC 바로가기 [Article Type] Research Article
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort studyObservational Study Published on 2021-01-042022-10-04 Journal: Critical Care [Category] 임상, [키워드] attenuate cohort study Complication complications coronavirus disease Corticosteroid Corticosteroids COVID-19 Cox model Critically ill Critically ill patient dose dysregulated immune response Endpoint Fatality rate groups Hospital stay ICU ICU admission intensive care unit less low dose lower mortality Mortality multicenter multivariable no difference outcome outcomes Patient patients treated patients with COVID-19 Probability receive regimens Result secondary Secondary infection Spain treated treated patients use of corticosteroid Ventilator-free days Weighting with COVID-19 [DOI] 10.1186/s13054-020-03422-3 PMC 바로가기 [Article Type] Observational Study