Lung function – Page 11 – Communicable Diseases Research

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

TMEM16 단백질을 억제하는 약물은 SARS-CoV-2 스파이크 유도 융합체를 차단합니다

Article

Published on 2021-06-012022-09-11
Journal: Nature [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 진단, 치료기술, 치료제,

Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge

Review

Published on 2021-06-012023-06-19
Journal: Respiratory medicine [Category] MERS, SARS,

[키워드] ARDS COVID-19 diffusion capacity follow up ICU treatment Lung function
[DOI] 10.1016/j.rmed.2021.106394 PMC 바로가기 [Article Type] Review

Pulmonary long-term consequences of COVID-19 infections after hospital discharge

퇴원 후 COVID-19 감염의 폐 장기 결과

Article

Published on 2021-06-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 바이오마커,

[키워드] 6-minute walk test 6MWT 95%CI abnormality acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adhesion Molecule Biomarker Biomarkers carbon monoxide Chest computed tomography Comorbidities Computed tomography consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization COVID-19 infection diffusing diffusing capacity diffusion diffusion capacity discharge discharged patient discharged patients Effect epidemiological evaluated expiratory forced expiratory volume forced vital capacity FVC group hospital hospital discharge Hospital stay Hospitalization identify Inflammation information inhibitor inhibitors Intracellular Intracellular adhesion molecule IQR laboratory parameter Laboratory parameters laboratory-confirmed Lactate lactate dehydrogenase Limited Lung diffusion capacity Lung function matrix metalloproteinases median medical histories Multivariate analysis onset of symptom Osteoprotegerin Patient patients performed plasminogen Plasminogen activator inhibitor Proteases pulmonary Pulmonary function Pulmonary function tests Real-time PCR receptor receptors recovering from COVID-19 recruited respiratory Respiratory function Respiratory function test Respiratory function tests RT-PCR SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients screened serum serum lactate severe acute respiratory syndrome Coronavirus severe disease severe SARS-CoV-2 severity Spanish Sputum sample sputum samples survivor Symptom symptom onset Tissue Inhibitor Tissue inhibitor of matrix metalloproteinases tomography virus vital capacity Volume were measured
[DOI] 10.1016/j.cmi.2021.02.019 PMC 바로가기 [Article Type] Article

Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study

COVID-19 치료를 위한 잠재적인 용도 변경 약물 후보로서의 Rifampicin 및 Letermovir: in-silico 연구의 통찰력

Article

Published on 2021-06-012022-09-11
Journal: Pharmacological Reports [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS binding affinity caused clinical trials Combination Compound COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 treatment Cytokine storm docking study drug drug candidate Drug repurposing examined FDA approved drug FDA approved Drugs free energy Free energy calculations high viral load host immune system hour identify IL-1β IL-6 in vitro in-silico inhibit involved Letermovir Lung function M pro Main protease Mpro medical emergency molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations multiple organ failure outcome protease provide respiratory distress Respiratory distress syndrome rifampicin SARS-CoV-2 SARS-CoV-2 main protease selected subsequent supported surface area syndrome the cytokine storm the SARS-CoV-2 these compounds TNF-α Treatment Viral load Virtual screening was performed
[DOI] 10.1007/s43440-021-00228-0 PMC 바로가기 [Article Type] Article

Dysregulation of COVID-19 related gene expression in the COPD lung

COPD 폐에서 COVID-19 관련 유전자 발현의 조절 장애

Research

Published on 2021-05-292022-09-10
Journal: Respiratory Research [Category] 유전자 메커니즘,

[키워드] ACE inhibitor ACE inhibitors ACE2 ACE2 gene ACEi aetiology angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Basigin biopsies biopsy cardiovascular disease cathepsin cathepsin B Characteristics chronic chronic obstructive pulmonary disease Clinical course Control control subjects controls COPD coronavirus coronavirus 2 coronavirus disease correlated Corticosteroid COVID-19 determine disease disease phenotype downstream elevated enzyme epithelial expression expression of gene Gene Expression hypertension identify increased risk Infection Inflammation inhaled corticosteroid log2FC lung Lung function Obstructive obstructive pulmonary disease outcome Patient protease Proteases pulmonary disease quantified RAS RAS gene receptor regulated Regulation Renin renin-angiotensin system required respiratory Result RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Serine severe acute respiratory syndrome coronavirus 2 subject supplementary material susceptibility TMPRSS4 upregulated was increased
[DOI] 10.1186/s12931-021-01755-3 PMC 바로가기 [Article Type] Research

Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease

기도 질환의 실험적 마우스 모델에서 폐 기능의 비침습적 측정

Review

Published on 2021-05-192022-09-12
Journal: Lung [Category] MERS, SARS, 진단,

High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia

혈장 내 갈렉틴-9 및 오스테오폰틴의 높은 수준은 COVID-19 폐렴의 중증도를 반영하는 염증 마커와 관련이 있습니다

Article

Published on 2021-05-072022-09-10
Journal: International Journal of Molecular Sciences [Category] 바이오마커, 진단,

[키워드] Analysis association Bacterial infection C-reactive protein can be used cleaved Coagulopathy coronavirus disease Coronavirus disease 2019 Correlation analysis COVID pneumonia COVID-19 COVID-19 patient CP group CP patient CP patients elevated ferritin followed by form full-length full-length galectin-9 full-length osteopontin Galectin-9 healthy individuals highest Infectious diseases Inflammation inflammatory biomarkers inflammatory markers interleukin Kidney function Laboratory Level Lung function marker mild clinical symptom mild clinical symptoms MONITOR number osteopontin Patient Plasma level Plasma levels plasma sample plasma samples Pneumonia Proteases Protein reduced ROC analysis severity significantly Spearman’s correlation suggested therapeutic effect therapeutic effects therapy Tocilizumab treated truncated galectin-9 undefined osteopontin
[DOI] 10.3390/ijms22094978 PMC 바로가기 [Article Type] Article

A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19

Research article

Published on 2021-05-012022-10-05
Journal: The Lancet Regional Health - Europe [Category] 치료법, 치료제,

[키워드] administration adverse event AEs airway allergy analyses anti-SARS-CoV-2 Antiviral Antiviral treatment assigned Asymptomatic clinically Cohort cohorts conducted coronavirus disease 19 COVID-19 criteria defined Denmark Diseases dose double-blind evaluated event Evidence exhibited expiratory finding FIVE Frequency funding healthy volunteer healthy volunteers Infection Inhaled intranasal Lung function niclosamide nitric oxide Patient Phase 1 phase 1 trial Placebo placebo group placebo-controlled predicted primary endpoint Pulmonary function test Randomized Randomly receiving reported resolved Safety serious AE single dose therapy Treatment Trial trials upper respiratory tract variable viral respiratory Volume Volunteer was determined
[DOI] 10.1016/j.lanepe.2021.100084 [Article Type] Research article

Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers

COVID-19에 걸린 어린이의 혈액 호중구는 염증 및 항염증 마커를 모두 나타냅니다

Observational Study

Published on 2021-05-012022-08-31
Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 진단,

[키워드] Activation acute lung injury Adhesion Molecule adhesion molecules Adults analyzed Anti-inflammatory Asymptomatic Blood Blood samples Buenos Aire Buenos Aires CD11b CD64 CD66b Cell-adhesion molecules cell-free DNA children children with COVID-19 circulating neutrophil circulating neutrophils Concentration COVID-19 cytokine cytokine production Cytokines DNA ELISA expression Fcγ receptor flow cytometry fluorometry healthy children healthy controls HLA-DR IgG IgG antibodies IgG antibody immune response infiltration Inflammatory inhibitory receptor Inhibitory Receptors L-selectin low expression lower expression Lung function Lung injury marker Mild MIS-C Moderate COVID-19 NET NETs neutrophil Neutrophils no differences observational study PD-L1 pediatric pediatric COVID-19 phenotype plasma Plasma levels Prevent promotion quantified receptor respiratory respiratory symptoms SARS-CoV-2 Science serum severe COVID-19 severe respiratory symptom severe respiratory symptoms Spike protein supported syndrome technology the spike protein tissue university was performed were measured
[DOI] 10.1016/j.ebiom.2021.103357 PMC 바로가기 [Article Type] Observational Study

Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

Observational Study

Published on 2021-04-292022-10-05
Journal: The European Respiratory Journal [Category] SARS, 임상,

[키워드] Abnormalities abnormality acute respiratory syndrome all subject Analysis cardiac Cardiopulmonary clinical examination Cohort Computed tomography conducted coronavirus disease COVID-19 COVID-19 patient CT scan demonstrated Diagnosis diagnosis of COVID-19 diffusing Dyspnoea evaluated exhibited Follow-up ground-glass opacity impaired lung function impairment Laboratory testing low-dose Lung function lung lobes Lung pathology multicentre outbreak Patient patients post-COVID-19 patient pulmonary fibrosis pulmonary hypertension questionnaire radiological recovering from COVID-19 reduced subject subjects survivor Symptom Thoracic Trial ventricular
[DOI] 10.1183/13993003.03481-2020 PMC 바로가기 [Article Type] Observational Study