Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease Research Published on 2022-05-262022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] antibody Antigen antigenicity BALB/c mice Combination comparable convalescent plasma COVID-19 cases COVID-19 pandemic defined disease effective vaccine elevated elicited Emergency use Endpoint facilitate highlight immunization immunized immunogenic infected patients Infection Live virus Lung infection MERS-CoV neutralization titer neutralizing antibody responses Particle pathogenic coronavirus physiochemical property platform PLP PROTECT Protein provide RBD RBD-specific IgG robust SARS-CoV-2 SARS-CoV-2 variant serum the receptor-binding domain the United State These data Vaccine Vaccines [DOI] 10.1038/s41541-022-00481-1 [Article Type] Research
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cellsArticle Published on 2022-05-242023-07-09 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), [키워드] endonuclease U innate immune antagonism. MERS-CoV PKR RNase L [DOI] 10.1073/pnas.2123208119 PMC 바로가기
Isothermal gene amplification coupled MALDI-TOF MS for SARS-CoV-2 detectionSARS-CoV-2 검출을 위한 등온 유전자 증폭 결합 MALDI-TOF MSArticle Published on 2022-05-152022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis coronavirus COVID-19 current demonstrated detect early diagnosis effective false-negative false-negative results Frame Gene detection infected individual infected individuals isothermal lack MALDI-TOF MS MERS MERS-CoV Mutation nucleocapsid Open reading frame other coronaviruses pandemic pseudovirus risk Rolling Rolling circle amplification Saliva SARS-CoV SARS-CoV-2 SARS-CoV-2 detection SARS-like coronavirus severe acute respiratory syndrome Coronavirus specificity temperature Urine Vaccines Virus analysis. water [DOI] 10.1016/j.talanta.2022.123297 PMC 바로가기 [Article Type] Article
Recent Chronology of COVID-19 PandemicArticle Published on 2022-05-042023-06-15 Journal: Frontiers in Public Health [Category] MERS, [키워드] COVID-19 MERS-CoV pandemic SARS-CoV SARS-CoV-2 [DOI] 10.3389/fpubh.2022.778037 PMC 바로가기
Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.Article Published on 2022-05-032022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody apex B.1.351 B.1.617.2 bind CDR3 complex structure conformational coronavirus CoV COVID-19 cryo cryo-EM Cryoelectron microscopy dose Dromedary dromedary camel nanobody VHH Epitopes expressing hACE2 heterodimer high affinity human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 humans involved MERS-CoV Middle East Middle East respiratory syndrome Middle East Respiratory Syndrome CoV nanobodies nanobody neutralization activity neutralize Neutralizing neutralizing antibody nonoverlapping epitope nonoverlapping epitopes platform Protein RBDs Receptor-binding domain receptor-binding domains recognize reservoir residue S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single-domain antibody syndrome target the RBD the S1 subunit therapeutic use transgenic mice transmitted trimer unique variant variants variants of concern viruses [DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article
Photonics enabled intelligence system to identify SARS-CoV 2 mutationsSARS-CoV 2 돌연변이를 식별할 수 있는 포토닉스 지원 지능 시스템Review Published on 2022-05-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] amplification Analysis approach artificial intelligence caused Characteristics characterized Comparative component country COVID-19 COVID-19 test COVID-19 variant death Efficiency Epidemics Evaluating flexibility General population global health greater Health healthcare human population identify IMPROVE indicate intelligence Intelligence system Internet MERS-CoV modify molecular Mutation mutations occur omicron Omicron variant optical other variants Outbreaks Photonic photonics Planning Precision Protein repeated SARS-CoV SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 mutation spike Spike protein Spread the SARS-CoV-2 Transmission variant Variation virus virus detection [DOI] 10.1007/s00253-022-11930-1 PMC 바로가기 [Article Type] Review
A Tale of Two Countries: DiaSorin Molecular’s Rapid Response to the COVID-19 Pandemic두 나라 이야기: COVID-19 팬데믹에 대한 DiaSorin Molecular의 신속한 대응Article Published on 2022-04-212022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] accelerated Canada challenge clinical samples Cluster coronavirus COVID-19 databases detect develop diagnostic diagnostic test diagnostics diagnostics manufacturer DiaSorin DiaSorin Molecular Direct Diseases Emerging infectious diseases etiology Europe Infectious diseases Italy lab LIAISON LIAISON MDX MERS-CoV multiplex new SARS-CoV-2 overcome pandemic platform Pneumonia pneumonia case pneumonia cases Rapid Rapid diagnostic test raw materials reagents Research research and development respiratory respiratory infection respiratory infections response RT-PCR SARS-CoV-2 SARS-CoV-2 virus side Simplexa summer target region targets Undetermined unique virus Wuhan Wuhan, China [DOI] 10.3389/fcimb.2022.840210 PMC 바로가기 [Article Type] Article
Synthesis of Dihydrobenzofuro[3,2-b]chromenes as Potential 3CLpro Inhibitors of SARS-CoV-2: A Molecular Docking and Molecular Dynamics StudySARS-CoV-2의 잠재적인 3CLpro 억제제로서의 디하이드로벤조푸로[3,2-b]크로멘 합성: 분자 도킹 및 분자 역학 연구Article Published on 2022-04-202022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro 3CLpro inhibitors acute respiratory syndrome acute respiratory syndrome coronavirus approach Bioactivity bioinformatics caused chymotrypsin Clustering analysis Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease derivatives drug target Dynamics enzyme flavonoid flavonoids fused fused flavonoids Health in-silico Infection inhibitor inhibitor N3 inhibitors life cycle MERS-CoV methodology Middle East Middle East respiratory syndrome Coronavirus molecular molecular docking molecular dynamics Molecular dynamics simulation molecular interaction pandemic Potential Protein raised respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus synthesis therapeutic Toxicity unavailability viral life cycle [DOI] 10.1002/cmdc.202100782 PMC 바로가기 [Article Type] Article
Capacitive biosensor based on vertically paired electrodes for the detection of SARS-CoV-2SARS-CoV-2 검출을 위한 수직 쌍 전극을 기반으로 하는 정전 용량 바이오센서Article Published on 2022-04-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] 229E anti-SARS-CoV-2 applied Capacitive biosensor Computer simulation Conductive polymer cultures cutoff value diagnosis of COVID-19 different electrode dilution factor Dry etching electrode enhancement etched immunoassay in viral increase in lateral flow immunoassay limit of detection medical diagnosis MERS MERS-CoV nucleoprotein Nucleoprotein (NP) PEDOT:PSS Polymer reactive SARS-CoV SARS-CoV-2 SARS-CoV-2 nucleoprotein sensitivity Vertically paired electrode. viral culture was performed [DOI] 10.1016/j.bios.2022.113975 PMC 바로가기 [Article Type] Article
Advances in the Development of SARS-CoV-2 Mpro InhibitorsSARS-CoV-2 Mpro 억제제 개발의 발전Review Published on 2022-04-142022-09-11 Journal: Molecules [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] acting advance antiviral drugs carried Chemical structure Compound COVID-19 demonstrated development displaying drug effort high affinity inhibitor inhibitors Initially main protease MERS MERS-CoV MPro outbreak peptide peptides protease Proteases reactive reported SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Scientific community sequence small molecule tested these compound these compounds virus [DOI] 10.3390/molecules27082523 PMC 바로가기 [Article Type] Review