Incidence, characteristics and clinical profile of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in patients with pre-existing primary immune thrombocytopenia (ITP) in SpainObservational Study Published on 2021-08-012022-10-05 Journal: British Journal of Haematology [Category] SARS, 임상, [키워드] acute respiratory syndrome Characteristics chronic collected coronavirus disease Coronavirus-2 COVID-19 Evolution Factor group Hyperactivation Immune thrombocytopenia Immunosuppression incidence increase in Infection Inflammatory influence ITP modify multicentre National Patient persistent Platelet SARS-CoV-2 SARS-COV-2 infection severity Spain Spanish Steroids subsequent Treatment [DOI] 10.1111/bjh.17506 PMC 바로가기 [Article Type] Observational Study
High-Throughput Multiplex SARS-CoV-2 IgG Microsphere Immunoassay for Dried Blood Spots: A Public Health Strategy for Enhanced Serosurvey Capacity건혈 반점에 대한 고처리량 멀티플렉스 SARS-CoV-2 IgG 미소구체 면역분석: 혈청 조사 능력 향상을 위한 공중 보건 전략Research Article Published on 2021-07-282022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] 384-well plate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody Antibody test antibody tests Antigen antigens Asymptomatic individuals automated Blood Capacity categories collected conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Decision making demonstrated detect diagnostic diagnostic test diagnostic testing dried blood spot Dried blood spots early phase enhanced estimate fluorescence intensity Health care Health care worker IgG IgG antibodies IgG antibody immunoassay immunoassays invasive laboratory-confirmed SARS-CoV-2 infection MFI MIA microsphere modify multiplex New York nucleocapsid pandemic populations positive correlation Positive test Prevalence prevalence of COVID-19 Public public health R 2 ranged respiratory resulting robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sensitivity sera serology Seroprevalence Serosurvey Serosurveys serum severe acute respiratory syndrome Coronavirus significantly higher specificity spring state Strategy stratified subunit Symptom symptom data symptomatic Testing the SARS-CoV-2 Vaccines validation study variant variety [DOI] 10.1128/Spectrum.00134-21 PMC 바로가기 [Article Type] Research Article
Conspiracy Theories, Psychological Distress, and Sympathy for Violent Radicalization in Young Adults during the COVID-19 Pandemic: A Cross-Sectional StudyArticle Published on 2021-07-242022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval association Canada COVID-19 COVID-19 conspiracy theories COVID-19 pandemic effort high psychological distress individual Intention Interaction magnitude mitigate modify participant promoted Psychological Psychological distress public health question Radicalization significant interaction Spread Support Sympathy violent radicalization [DOI] 10.3390/ijerph18157846 PMC 바로가기 [Article Type] Article
Vaccine escape in a heterogeneous population: insights for SARS-CoV-2 from a simple modelScience, Society and Policy Published on 2021-07-142022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] clinical trial concerning Contact COVID-19 demonstrated develop disease effective effective vaccine Effectiveness epidemiological group heterogeneous heterogeneous population highest Infection mathematical modify mutate Mutation occur pandemic Policy Prevalence reduce reducing risk SARS-CoV-2 selection pressure subsequent the SARS-CoV-2 the SARS-CoV-2 virus vaccination Vaccine vaccine escape vaccine-induced immune response Vaccines variants widespread [DOI] 10.1098/rsos.210530 PMC 바로가기 [Article Type] Science, Society and Policy
Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infectionSARS-COV-2 감염에 대한 항바이러스제 전달을 위한 바이러스 스파이크 단백질의 RBD로 태그가 지정된 세포외 소포Article Published on 2021-07-102022-09-11 Journal: Journal of controlled release : official journal o [Category] SARS, 치료제, [키워드] accumulate ACE2 ACE2 receptor antiviral agent Antiviral agents approach binding domain Cell cellular cellular entry develop domain effective encapsulate endocytosed Express Extracellular extracellular vesicle Extracellular vesicles fusion hACE2 highlight in vivo Infection Interaction lung tissue lung tissues membrane membrane protein Membrane proteins modify molecular provide pseudovirus infection RBD Receptor binding domain receptor binding domain (RBD) Receptor-binding domain recognize required Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus siRNA siRNAs specific tissue specific tissues Spike protein spread of COVID-19 suppress Tagged target cells target tissue target tissues targeting the RBD the receptor-binding domain therapeutic potential Therapeutics tissue Transgenic mouse viral spike protein [DOI] 10.1016/j.jconrel.2021.05.049 PMC 바로가기 [Article Type] Article
Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19Research Published on 2021-07-082022-10-28 Journal: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology [Category] COVID-19, [키워드] Asthma asthma patient asthmatic Blood CCL2 circulating clinical information collected Comorbidity Concentration correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 progression COVID-19 severity Critical CRP CXCL10 cytokine cytokine response Cytokine storm disease severity group groups healthy subject Hospital stay IL-6 IL-8 immune response Impact implicated John Radcliffe Hospital Mild modify Mortality neutrophil counts no difference occur Oxford oxygen saturation Patient plasma sample Prevalence Protein respiratory virus Result severity of COVID-19 significant difference Total were measured [DOI] 10.1186/s13223-021-00569-8 PMC 바로가기 [Article Type] Research
Hairpin-Spherical Nucleic Acids for Diagnosing COVID-19: a Simple Method to Generalize the Conventional PCR for Molecular AssaysCOVID-19 진단을 위한 머리핀-구형 핵산: 분자 분석을 위한 기존 PCR을 일반화하는 간단한 방법Article Published on 2021-07-062022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] absence acid activator acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Arm AuNP Chain Reaction clinical sample colorimetric detection conserved Conventional coronavirus COVID-19 COVID-19 pandemic detect develop diagnostic diagnostic testing Disease diagnosis DNA DNA polymerase E gene effort exonuclease Final gold Gold nanoparticle Infection Infectious disease Ligand loop modify nucleic acid nucleic acids pandemic Patient PCR PCR cycle PCR product polymerase chain polymerase chain reaction positive presence or absence probe Real-time reverse transcription PCR real-time RT-PCR Region Research reverse transcription PCR RNA RT-PCR SARS-CoV-2 SARS-CoV-2 RNA sensitivity sequence severe acute respiratory syndrome Coronavirus simple STEM TaqMan TaqMan probe [DOI] 10.1021/acs.analchem.1c01515 PMC 바로가기 [Article Type] Article
Diagnostic and therapeutic endonasal rhinologic procedures generating aerosol during COVID-19 pandemic: a systematized reviewReview article Published on 2021-07-012022-10-05 Journal: Brazilian Journal of Otorhinolaryngology [Category] SARS, 진단, [키워드] acute respiratory syndrome Aerosol generation Aerosols article Cancer Care coronavirus COVID-19 COVID-19 pandemic COVID‐19 database endoscopic sinus surgery Epistaxis equipment Evidence healthcare Infection prevention Infectious disease information modify MOST nasal Nasal endoscopy objective Patient care Personal protective equipment producing provided recommendation Respiratory droplets Result risk SARS-Co SARS‐CoV‐2 skull base surgery Spread therapeutic tissue Web of Science [DOI] 10.1016/j.bjorl.2020.11.008 [Article Type] Review article
Harnessing immunotherapy to combat COVID-19: A modern snake oil or silver bullet?COVID-19 퇴치를 위한 면역 요법 활용: 현대의 뱀 기름 또는 은탄?Review Published on 2021-07-012022-09-11 Journal: Thérapie [Category] SARS, 진단, 치료제, [키워드] (hydroxychloroquine) (remdesivir acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral antibodies Azithromycin caused clinical trial clinical trials Combination convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 serotherapy drug Epidemiology Health human monoclonal antibodies Human monoclonal antibody Hydroxychloroquine IFN-I immune response immune responses immunopathology Immunotherapy Infectious disease interfere interferon Interferon type I interferons intracellular pathogens mAbs modify monoclonal antibodies outcome Pathogenesis Pathogens Patient physician regimen Remdesivir respiratory SARS-CoV-2 serotherapy severe acute respiratory syndrome Coronavirus survival Treatment outcome [DOI] 10.1016/j.therap.2020.10.004 PMC 바로가기 [Article Type] Review
Mechanistic Analysis of Age-Related Clinical Manifestations in Down SyndromeNeuroscience Published on 2021-07-012022-10-31 Journal: Frontiers in Aging Neuroscience [Category] COVID-19, [키워드] Abnormalities abnormality age Alzheimer’s disease Alzheimer’s disease Amino acid app Brain C-terminal Characteristics chromosome 21 clinical clinical manifestation COVID-19 Dementia disease dose Down syndrome Evidence facial facilitate Features genetic cause growth hearing loss immune system Impact Infection interferon pathway manifestation mechanism mechanisms modify pathology phenotype plaque severity of COVID-19 therapeutic intervention trisomy trisomy 21 [DOI] 10.3389/fnagi.2021.700280 PMC 바로가기 [Article Type] Neuroscience