MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis
Research Article
[키워드] accumulate
BBB, blood brain barrier
Blood brain barrier
CD4
CD4 T cells
CD8
Central nervous system
chemokine
CNS
CNS, Central Nervous System
coronavirus
decrease
disease severity
EAE, experimental autoimmune encephalitis
Encephalitis
expression
facilitate
Glia
glia limitans
IFNγ, interferon γ
IFNγ
induce
Infection
Infectious virus
Inflammatory response
interferon γ
limitans
mAb, monoclonal antibody
matrix metalloproteinase
matrix metalloproteinases
MHV, mouse hepatitis virus
mice
Migration
MMP, matrix metalloproteinase
neurotropic
not affected
Pathogenesis
perivascular
perivascular cuff
PFA, paraformaldehyde
recruitment
reduced
responsible
suggested
T cell
T cell subset
T cells
TIMP-1
TIMP, tissue inhibitor of matrix metalloproteinases
tissue damage
Tissue Inhibitor
virus
WT, wild-type
[DOI] 10.1042/AN20130033 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1042/AN20130033 PMC 바로가기 [Article Type] Research Article