Detect and destroy: CRISPR-based technologies for the response against viruses탐지 및 파기 : CRISPR 기반 바이러스 대응 기술Review Published on 2021-05-122022-09-11 Journal: Cell Host & Microbe [Category] SARS, 변종, 치료기술, 치료제, [키워드] accelerated adaptive immune system Bacterial class 2 Cas proteins COVID-19 pandemic CRISPR CRISPR-based antivirals CRISPR-based detection CRISPR-Ca Critical diagnostic diagnostics global pandemic highlight Infectious disease Initially nucleic acids therapeutic Therapies unique viral diagnostics viral nucleic acid viral nucleic acids viral outbreak viral replication virus viruses [DOI] 10.1016/j.chom.2021.04.003 PMC 바로가기 [Article Type] Review
Methodical Design of Viral Vaccines Based on Avant-Garde Nanocarriers: A Multi-Domain Narrative ReviewReview Published on 2021-05-062022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] approach caused compounds Corona Coronavirus 2019 COVID-19 Degradation different diseases drug delivery generate Health immune responses lipid particles liposomes long-lasting management nanoliposomes narrative nucleic acids other molecules outbreak pathogen peptides Protective review SARS-CoV-2 target cells the vaccine theranostics tocosome Vaccine Vaccine design Viral diseases virus [DOI] 10.3390/biomedicines9050520 PMC 바로가기 [Article Type] Review
Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests낮은 타액 pH는 간단한 RT-LAMP 기반 SARS-CoV-2 진단 테스트에서 위양성 결과를 산출할 수 있습니다.Research Article Published on 2021-05-052022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] amplification can be used causative agent COVID-19 COVID-19 infection Diagnostic method diagnostic test dissemination False positive fluctuation hospital Hospital environment Infectious disease isothermal lack Modification nasopharyngeal sample Nasopharyngeal swab nasopharyngeal swabs nucleic acids Prevent reliability RNA extraction RNA purification RT-LAMP RT-qPCR RT-qPCR test Saliva salivary SARS-CoV-2 SARS-CoV-2 detection sensitivity Treatment Viral viral nucleic acids VTM [DOI] 10.1371/journal.pone.0250202 PMC 바로가기 [Article Type] Research Article
Magnetization Transfer to Enhance NOE Cross‐Peaks among Labile Protons: Applications to Imino–Imino Sequential Walks in SARS‐CoV‐2‐Derived RNAsResearch Article Published on 2021-05-042022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] Coronavirus, SARS, [키워드] 2D NMR spectroscopy analyzed application approach boost CEST correlation demonstrated ENhance experiment explained faster Genome introduced labile limitation Magnetization magnitude mechanism NMR NMR spectroscopy NOESY nucleic acids proton protons recorded resulting RNA RNA fragment RNAs SARS-CoV-2 SARS‐CoV‐2 saturations selected selective sensitivity structures transfer [DOI] 10.1002/anie.202015948 PMC 바로가기 [Article Type] Research Article
50 Years of structural immunologyJBC Reviews Published on 2021-05-032022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, [키워드] adaptive antibodies antibody Antigen antigens build CDR, complementarity-determining region cellular cellular immunity CoV, coronavirus cytokine engage EPO, erythropoietin EPOR, erythropoietin receptor equivalent example explained germline gene GP, glycoprotein HA, hemagglutinin hGH, human growth hormone host cell Humoral immunity Ig, immunoglobulin immune recognition immune response immune system Immunity immunological immunology include Inflammation information inherent innate immune system lipids MHC MHC molecule MHC, major histocompatibility complex microbial microbial pathogens momentum MR, molecular replacement Mutation NA, neuraminidase NKT cell, natural killer T cell NTD, N-terminal domain nucleic acids pathogen PDB, Protein Data Bank peptide processed Protein protein antigen Proteins RBD, receptor-binding domain receptor receptors recognize Recombination regulate RSV, respiratory syncytial virus SARS-CoV-2 Small molecules specificity Structure Surface glycoprotein T cell receptors T cells target TCR, T cell receptor the antibody response TLR TLR, Toll-like receptor Vaccine viral antigens virus VLR VLR, variable lymphocyte receptor [DOI] 10.1016/j.jbc.2021.100745 PMC 바로가기 [Article Type] JBC Reviews
Clinical applications for exosomes: Are we there yet?Review Article Published on 2021-05-032022-10-28 Journal: British Journal of Pharmacology [Category] Coronavirus, MERS, SARS, [키워드] approach Biomarker Cancer carrier clinical clinical development clinical trials Clinical use cross diagnostic diagnostic biomarker disease Efficacy Exosome extracellular vesicle functional protein good manufacturing practice Health immunomodulation Infectious diseases Inflammation limitation Liposome manufacturing metabolites nucleic acids physiological reduced Research subset therapeutic therapeutic agents therapeutic purposes Therapeutics Transport Viral vector [DOI] 10.1111/bph.15432 PMC 바로가기 [Article Type] Review Article
Fast Detection of SARS-CoV-2 RNA Directly from Respiratory Samples Using a Loop-Mediated Isothermal Amplification (LAMP) Test루프 매개 등온 증폭(LAMP) 테스트를 사용하여 호흡기 샘플에서 직접 SARS-CoV-2 RNA의 빠른 검출Article Published on 2021-04-292022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] analytical sensitivity analyzed COVID-19 COVID-19 pandemic demonstrated detect detection direct testing examined in viral investigated isothermal Laboratory LAMP Loop-mediated isothermal amplification medium moderate nasopharyngeal swabs Negative predictive value NPs nucleic acid nucleic acids performed phosphate Phosphate Buffered Saline Positive predictive value Predictive value rapid antigen test Rapid antigen tests Rapid test Rapid tests reactive resources respiratory respiratory sample Respiratory samples reverse transcription RT-PCR Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA sensitivity specificity Swab swab sample swabs Test tested Transport transport medium Viral Viral transport medium VTM [DOI] 10.3390/v13050801 PMC 바로가기 [Article Type] Article
Amplification-free RNA detection with CRISPR–Cas13CRISPR–Cas13을 사용한 증폭 없는 RNA 검출Article Published on 2021-04-192022-09-10 Journal: Communications Biology [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] amplification Concentration CRISPR detect Detection sensitivity develop diagnostics ENhance Enzymes guide RNA guide RNAs molecular molecular diagnostics much lower N gene N-gene Nanobiotechnology nucleic acid nucleic acids platform proof RNA SARS-CoV-2 N gene sensitivity single-stranded specificity target the SARS-CoV-2 utility [DOI] 10.1038/s42003-021-02001-8 PMC 바로가기 [Article Type] Article
Plasmonic Biosensors for Single-Molecule Biomedical AnalysisReview Published on 2021-04-152022-10-27 Journal: Biosensors [Category] Coronavirus, MERS, SARS, [키워드] Analysis approaches binding affinity Biomarker biosensor biosensors clinically contributed coronavirus disease Diagnosis effort epidemic disease interactions limitation living cells living-cells medical condition nanoparticle nanostructure nucleic acid nucleic acids overcome Personalized medicine plasmonics Proteins single-molecule analysis Spread utility variety virus viruses [DOI] 10.3390/bios11040123 PMC 바로가기 [Article Type] Review
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelatorsReview article Published on 2021-04-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, [키워드] Activation amplified anti-inflammatory effect antiviral activities Apoptosis Blood groups cell death cellular characterized clinical condition clinical conditions coronavirus COVID-19 COVID-19 pandemic dysregulation Evidence Ferroptosis Free iron Hemoglobin damage host cells Hypercoagulation Hyperferritinemia immune dysfunction immunogenic immunomodulatory implicated increasingly Inflammation Inflammatory iron Iron chelators iron overload lactoferrin lipids living cells manifestation nucleic acids pathogenesis of COVID-19 Patient potentially toxic promote PROTECT Proteins reaction reactive reactive oxygen specy receptor resulting ROS Safe therapeutic Treatment [DOI] 10.1016/j.biopha.2021.111228 [Article Type] Review article