Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 PatientsCellular and Infection Microbiology Published on 2021-10-212022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] addition alpha-defensin Analysis asymptomatic individual Biomarker calprotectin Clinical presentations comparable COVID-19 COVID-19 patient COVID-19 patients DEFA1 disease disease severity elevated healthy subject healthy subjects independent Level mechanical ventilation Mild mild patient MPO myeloperoxidase neutrophil onset of disease outcome Patient pro-inflammatory cytokine Prognostic markers Protein Proteins recovering patient reduced S100A8/A9 SARS-COV-2 infection Secondary infection secondary infections Serum level severity significantly higher therapeutic option through contact understanding [DOI] 10.3389/fcimb.2021.751232 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Multisystem Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Role of Oxidative StressImmunology Published on 2021-10-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] abdominal pain Characteristics children correlated country COVID-19 Cytokines dysfunction effective Fever Immunological response Inflammation Inflammatory information Initially involved Kawasaki disease mechanisms MIS MIS-C molecular mechanism multisystem inflammatory syndrome in children multisystemic occur Older oxidative stress pathophysiology Patient positive Prevent pro-inflammatory cytokine reported role SARS-CoV-2 SARS-COV-2 infection Severe case severe COVID-19 similarity Spread suggested Support syndrome the disease the SARS-CoV-2 virus tissue damage unique Vascular damage [DOI] 10.3389/fimmu.2021.723654 PMC 바로가기 [Article Type] Immunology
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)Research Published on 2021-10-182022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured [DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research
Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19Review Published on 2021-10-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accumulating aggregation alteration Anti-inflammatory therapy Atherosclerosis Bioavailability Bone marrow cardiovascular disease changes characterized Complication Coronavirus disease-19 COVID-19 Critical Cytokines dysregulated endothelial Endothelium Evidence focus functional implicated induce Inflammation Inflammatory Interaction mediator Modification morbidity and mortality myeloperoxidase Neutrophil extracellular trap pandemic Platelet platelet activation pro-inflammatory cytokine receptor receptors thrombotic Thrombotic complications TNF-α Vascular endothelium von Willebrand factor [DOI] 10.3390/ijms222011170 PMC 바로가기 [Article Type] Review
Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine ResponsesImmunology Published on 2021-10-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation Adaptive immune response baseline CCL4 chemokine chemokines Covaxin COVID-19 CX3CL1 CXCL1 CXCL10 CXCL2 cytokine Cytokines GM-CSF healthy volunteers IFNs IFNγ IL-10 IL-12 IL-13 IL-17A IL-1α IL-1β IL-2 IL-33 IL-4 IL-5 IL-6 IL-7 inactivated induce investigated plasma pro-inflammatory cytokine recipients response robust SARS-CoV-2 SARS-CoV-2 vaccine systemic systemic immune response TNFα Type vaccination Vaccine virion [DOI] 10.3389/fimmu.2021.752397 PMC 바로가기 [Article Type] Immunology
Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary MacrophagesArticle Published on 2021-10-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Asparagus officinalis L. activating acute respiratory syndrome analyzed Asparagus attenuate attenuation Cell Cell signaling coronavirus coronavirus disease COVID-19 Degradation EAS Effect elicit enzyme-linked immunosorbent examined excessive inflammation Extract functional greater Host hydrogen peroxide IL-1β IL-6 induce Infection Inflammation inhibitor inhibitors Macrophage macrophages MAPK Mortality mRNA level N-terminal not affect nuclear nuclear translocation p65 patients with COVID-19 Phosphorylation polymerase chain pro-inflammatory cytokine pro-inflammatory response pro-inflammatory signaling Production Protein Proteins reducing reported reverse transcription S1 subunit SARS-CoV-2 secretion severity Signaling significantly Simultaneous treatment Skin fibroblasts spike Spike protein STEM subunit suppressed Suppressing the SARS-CoV-2 TLR4 toll-like receptor 4 Transcription ultraviolet unique viability were assessed [DOI] 10.3390/molecules26206189 PMC 바로가기 [Article Type] Article
Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19Pharmacology Published on 2021-10-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Anu AYUSH board Body weight loss characterized coronavirus coronavirus disease COVID-19 cytokine Effect exhibited expression Formulation Genes hamster Herbal histopathological indicated Infection inhibiting initiate intranasal lung Lung pathology Model molecular analysis mRNA expression Oil plant pro-inflammatory cytokine Prophylactic provided Pulmonary pathology reduced reduction in Respiratory failure SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection severity Th1 Th17 upper respiratory tract viral entry Viral load virus [DOI] 10.3389/fphar.2021.746729 PMC 바로가기 [Article Type] Pharmacology
Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?Review Published on 2021-10-072022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Acute coronary syndrome association Atherosclerosis cardiovascular disease Chronic disorder Complication condition COVID-19 COVID-19 infection Cytokine storm disease host’s immune response Inflammation Inflammatory miRNA Modification Patient periodontal periodontal disease pro-inflammatory cytokine responsible secreted systemically tissue while [DOI] 10.3390/life11101050 PMC 바로가기 [Article Type] Review
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage InteractionsSARS-CoV-2-인간 대식세포 상호작용에 대한 타고난 면역 반응 정의Immunology Published on 2021-10-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation activity acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARDS characterized chemokine component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dendritic cells dysregulation end-organ end-organ disease Evidence evidence of expression Host human monocyte human monocyte-derived macrophages IFN immune Infection Inflammation Inflammatory Innate innate immune innate immune response Interaction interferon investigated life-threatening coronavirus disease Macrophage macrophages malfunctions monocyte-macrophage Monocytes mononuclear phagocyte mononuclear phagocytes morbidities pro-inflammatory pro-inflammatory cytokine profile proteomic proteomics receptor respiratory respiratory distress Respiratory distress syndrome response robust SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus signaling pathways syndrome systemic inflammation the SARS-CoV-2 tissue damage transcriptomic transcriptomics type I interferon Viral viral infection viral replication virion virions while [DOI] 10.3389/fimmu.2021.741502 PMC 바로가기 [Article Type] Immunology
Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case studyACE(I/D)와 ACE2 수용체 유전자(Rs2106809, Rs2285666)의 다형성은 코로나19의 임상 경과와 관련이 없음: 사례 연구Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 ACE2 gene ACE2 receptor gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency angiotensin Angiotensin-converting enzyme caused Chain Reaction Clinical course Clinical symptoms coagulation indicators coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 severity Critical Cytokines distribution enzyme Epigenetic Evidence expression Genotype groups human ACE2 receptor I/D I/D polymorphism Infection Infectious disease influence insertion/deletion mechanism Mild moderate outcome pandemic Pathogenesis PCR polymerase chain polymerase chain reaction polymorphism Polymorphisms pro-inflammatory cytokine pro-inflammatory cytokines reason receptor rs2106809 rs2285666 rs2285666. SARS-CoV-2 SARS-CoV-2 susceptibility SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severity severity of COVID-19 statistically significant study population suggested susceptibility the SARS-CoV-2 virus three group three groups Variation variations with COVID-19 [DOI] 10.1002/jmv.27160 PMC 바로가기 [Article Type] Article