Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative StudyBrief Report Published on 2022-01-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age assessment BNT162b2 BNT162b2 vaccine Comparative COVID-19 group highest immune response individual investigated levels of antibody magnitude median Moderna-mRNA-1273 mRNA COVID-19 vaccines mRNA-1273 NAb NAbs naïve Neutralizing antibodies neutralizing antibody of BNT162b2 offer Older age Pfizer-BNT162b2 produced protective immunity reducing response SARS-CoV-2 second dose shown significantly higher Spread vaccination Vaccine [DOI] 10.3390/vaccines10020191 PMC 바로가기 [Article Type] Brief Report
Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primatesArticle Published on 2022-01-212022-10-04 Journal: NPJ Vaccines [Category] 변종, [키워드] animal model animal models antibodies antiviral responses binding clinical trials contribute COVID-19 vaccine cross-neutralizing antibody dose Efficacy hamster Humoral immunity induce Infection intramuscular intranasal Live attenuated vaccines Lower respiratory tract Lung injury non-human primate nucleocapsid antigens PROTECT protective immunity regimens robust SARS-CoV-2 SARS-CoV-2 vaccine synthetic T cells Trigger vaccination Vaccine variants viral infection weight loss [DOI] 10.1038/s41541-022-00436-6 PMC 바로가기 [Article Type] Article
Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T 세포를 정량화하고 표현형을 지정하기 위한 신속하고 간소화된 전혈 기반 다중 매개변수 분석Article Published on 2022-01-132022-09-11 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Blood CD4 CD4 T-cell Cell cells convalescent coronavirus COVID-19 detectable Differentiated cells evaluate flow cytometry granzyme healthcare worker IFN-γ Immunity indicated interferon memory MONITOR natural infection Necrosis participant Participants PCR-negative Peripheral blood phenotype protective immunity Rapid Rapid tests reported symptoms representing respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Symptom T-cell T-cell Response T-cell responses T-cells tested trials tumour necrosis factor tumour necrosis factor-α Vaccine Vaccine-induced immunity Whole blood [DOI] 10.1183/13993003.00285-2021 PMC 바로가기 [Article Type] Article
Nanotechnologies in Delivery of DNA and mRNA Vaccines to the Nasal and Pulmonary MucosaReview Published on 2022-01-112022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] adjuvants Administered airway antigen-presenting cells caused clearance COVID-19 delivery DNA DNA vaccine enzyme epithelial exogenously facilitate Genetic Host ideal Immunity immunization in vitro induce infect Infection Infectious disease Inhaled intranasal delivery mRNA mRNA vaccine mucosa mucosal mucosal immune response mucosal surfaces Nanoparticles Nanotechnology nasal nucleic acid nucleic acid vaccine nucleic acid-based vaccine overcome pathogen physical PROTECT Protective protective immunity pulmonary pulmonary delivery recent SARS-CoV-2 transcribed vaccination Vaccine variety while [DOI] 10.3390/nano12020226 PMC 바로가기 [Article Type] Review
Recruitment of highly cytotoxic CD8 + T cell receptors in mild SARS-CoV-2 infection경증 SARS-CoV-2 감염에서 세포독성이 높은 CD8 + T 세포 수용체 모집Article Published on 2022-01-112022-09-11 Journal: Cell Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen CD8 CD8(+) T cells Combination convalescent individuals coronavirus Cytotoxic T cells cytotoxicity demonstrated epitope Epitopes feature functional gene signature gene signatures heterogeneous HLA human leukocyte antigen Immunity immunodominant infected cells Infection investigated leukocyte Mild mild COVID-19 mild SARS-CoV-2 infection polyclonal Protective protective immunity Quantitative recruited respiratory responses retrieved SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection scRNA sequencing. Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell immunity T cell receptor T cells TCR TCR engineering TCR identification TCRs virus-infected cells [DOI] 10.1016/j.celrep.2021.110214 PMC 바로가기 [Article Type] Article
Machine learning for emerging infectious disease field responsesArticle Published on 2022-01-102022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] age and gender analysed approach biomedical engineering Comorbidity COVID-19 pandemic demonstrated develop Disease progression Effect effective Emerging infectious disease global public health Health services healthcare healthcare facility Hospital admission identify imperative Infectious disease Infectious diseases Laboratory tests machine medical resource minor symptom mortality risk occurred outbreak Patient patients physician protective immunity public health raised response risk Risk factors Spread Vaccination strategy [DOI] 10.1038/s41598-021-03687-w PMC 바로가기 [Article Type] Article
[Potential challenges for large-scale uses of RTS, S/AS01 vaccine in malaria-endemic areas]Article Published on 2022-01-102024-08-28 Journal: Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi [Category] 말라리아, [키워드] malaria protective immunity RTS,S/AS01 vaccine.
Incidence of COVID-19 reinfection among Midwestern healthcare employeesObservational Study Published on 2022-01-042022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] assumption clinical unit Consensus COVID-19 COVID-19 infection Critical defined generate greater healthcare healthcare worker Immunity incidence Infection natural infection Observational cohort study participant protective immunity rate of infection Reinfection risk study period subsequent Support understanding vaccination [DOI] 10.1371/journal.pone.0262164 PMC 바로가기 [Article Type] Observational Study
Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell DepletionB 세포 고갈이 있는 자가 면역 질환 환자의 SARS-CoV-2 감염 및 예방 접종에 대한 체액 및 세포 면역 반응Article Published on 2022-01-012022-09-11 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] SARS, 치료법, [키워드] antibodies Antibody Response Antibody responses Autoimmune disease autoimmune disease patient Autoimmune diseases B cell B cells block Cellular immune response Control controls Critical Depletion enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunospot assay expected healthy control healthy controls humoral Humoral and cellular immune responses humoral immune response immune responses Infection interferon interferon-γ nucleocapsid nucleocapsid protein Nucleocapsid proteins Patient protective immunity response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination T cell T cell response T cell responses tested the patient the SARS-CoV-2 therapeutic These data vaccination were assessed [DOI] 10.1002/art.41914 PMC 바로가기 [Article Type] Article
A case with SARS-CoV-2 reinfection from India인도 SARS-CoV-2 재감염 사례Case Reports Published on 2022-01-012022-09-11 Journal: Indian journal of medical microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] absence anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies antibody be positive Chain Reaction cough COVID-19 demonstrated detectable develop Fever headache healthcare worker high risk hospital IgG IgG antibodies IgG antibody India Infection initial Neutralizing antibodies Patient polymerase chain polymerase chain reaction positive Prevent protective immunity protocol qRT-PCR real time Reinfection reverse transcriptase Reverse transcriptase polymerase chain reaction SARS-CoV-2 tested transcriptase [DOI] 10.1016/j.ijmmb.2021.09.010 PMC 바로가기 [Article Type] Case Reports