Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral ActivitySec61 억제제 아프라톡신 S4는 SARS-CoV-2를 강력하게 억제하고 광범위한 항바이러스 활성을 나타냅니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] activity anticancer Antiviral antiviral activities antiviral activity blocked broad-spectrum antivirals cellular characterization COVID-19 Dengue dengue virus double-membrane vesicles dsRNA elicit Endoplasmic reticulum high potency Host host-directed therapeutics. human cells impacted in vitro in vivo Influenza influenza A influenza A virus inhibited inhibitor Microscopy Nile Pandemics Prevent prevented Protein Proteins reduced SARS-CoV-2 Sec61 shown Spike protein tested the spike protein translocation transmission electron microscopy vesicles Viral viral infection Viral protein viral replication virus West Zika [DOI] 10.1021/acsinfecdis.2c00008 PMC 바로가기 [Article Type] Article
Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis소아 및 장기 코로나의 다기관 염증 증후군: SARS-CoV-2 바이러스 초항원 가설Article Published on 2022-07-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Alter attribute autoantibodies autoantibody autoimmune responses Autoimmunity Bacterial binding Cell change children children with MIS-C circulating computational studies conjunctivitis conserved contribute COVID COVID-19 develop elevated exposure to feature febrile Fever Gastrointestinal glycoprotein Gut high affinity hyperinflammation immune response Immunosequencing Inflammatory inflammatory disease initial Kawasaki disease Long Long COVID MHC class II MHC Class II proteins MIS-C MIS-C multisystem inflammatory syndrome in children motif Multiorgan Neurological complication Neurological complications Neurological symptom Neurological symptoms neuronal neurotoxin neurotoxin-like segment oral mucosa PASC Patient patients pediatric Peripheral blood peripheral blood samples persistence persistent fever Post-acute sequelae of COVID-19 (PASC) prolonged exposure promote Proteins rashes resulting SAgs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus SEB Sequence analysis serum cytokine levels severity Shock similarity staphylococcal enterotoxin staphylococcal enterotoxin B strawberry strawberry tongue Structure superantigen superantigen-like motif. syndrome systemic hyperinflammation T-cell receptor TCR TCRs the SARS-CoV-2 the SARS-CoV-2 virus Toxic shock Toxic shock syndrome TRBV11-2 triggered TSS unique β variable [DOI] 10.3389/fimmu.2022.941009 PMC 바로가기 [Article Type] Article
Whole-genome analysis and mutation pattern of SARS-CoV-2 during first and second wave outbreak in Gwangju, Republic of Korea대한민국 광주에서 1차 및 2차 유행 중 SARS-CoV-2의 전체 게놈 분석 및 돌연변이 패턴Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed Cell culture circulating clade clinical clinical samples collected conducted Culture Deletion deletions determine dominant feature genetic diversity genomic genomic alteration high viral load in-depth analysis indicate Missense mutated Mutation Next-generation sequencing nucleic acid Nucleic acid purification outbreak Pathogenesis pathogenesis of SARS-CoV-2 Patient phylogenetic analyses Phylogenetic analysis Point mutation Proteins Region regions Research SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolates SARS-CoV-2 pathogenesis second wave significant difference South Korea statistical analysis therapeutic Viral load was performed whole genome [DOI] 10.1038/s41598-022-14989-y PMC 바로가기 [Article Type] Article
Safety and efficacy of a Siddha Medicine fixed regimen for the treatment of asymptomatic and mild COVID-19 patientsResearch article Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 신약개발, 치료법, [키워드] Admission All participant anti-SARS-CoV-2 antibody test antibody Asymptomatic Asymptomatic COVID-19 cardiac caused CBC Chennai clinical coronavirus 2 Coronavirus disease 2019 COVID COVID-19 COVID-19 disease COVID-19 patient cycle threshold Efficacy Electrolyte exploratory fixed function Intervention Kaba Sura Kudineer laboratory investigation Medicine Mild mild COVID-19 patient mild COVID-19 symptom negative non-randomized trial Notchi Kudineer oropharyngeal swab pandemic participant patients performed positive progression Proteins public health recruited reduce reduced regimen respiratory Result RT-PCR Safety SARS-CoV-2 severity severity of symptom Siddha Siddha Medicine significantly single-arm south India Standalone intervention Sura Symptom Symptomatic patients Tablet tablets Test Total treated Treatment Trial vitals [DOI] 10.1016/j.jaim.2022.100589 [Article Type] Research article
Emerging trends of edible vaccine therapy for combating human diseases especially COVID-19: Pros, cons, and future challenges인간 질병, 특히 COVID-19 퇴치를 위한 식용 백신 요법의 새로운 경향: 찬반 양론 및 미래 과제Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] 유전자 메커니즘, [키워드] administration clinical trials combating conventional vaccine conventional vaccines COVID-19 develop drugs edible vaccine effective effort Evidence human disease human diseases immunomodulatory mechanism mechanism of action minimum monoclonal antibodies oral administration oral vaccines Perspective plant plant-extracts plants PROTECT Proteins researcher SARS-CoV-2 Side effect Side effects stages therapy transgenic transgenic plant. Vaccine vaccine candidate Vaccines [DOI] 10.1002/ptr.7475 PMC 바로가기 [Article Type] Review
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeuticsSARS-CoV-2 Omicron 변이체의 컴퓨터 분석에서 얻은 통찰력: 숙주-병원체 상호작용, 병원성 및 가능한 약물 치료법Article Published on 2022-07-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Affect Alter Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity Characteristics Comparisons computational analysis correlated correlation correlations COVID-19 COVID-19 case COVID-19 cases docking docking result docking results drug Drug efficacy drugs drugs efficacy effective Effectiveness epidemiological evaluate evaluated Factor genomic sequence Host host-pathogen interaction human receptors insight Interaction lack less Lopinavir molecular docking molecular dynamics Molecular dynamics simulation Mutation mutational spectrum Nirmatrelvir NRP1 occurred omicron Omicron variant pathogenic pathogenicity Phylogenetic tree protease Protein Proteins raised Receptor-binding domain reconstructed Research response significant difference significant differences tested the receptor-binding domain the SARS-CoV-2 therapeutic approaches variant [DOI] 10.1002/iid3.639 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived CardiomyocytesSars-Cov-2 스파이크 단백질에 의한 hiPSC 유래 심근세포 손상Article Published on 2022-07-012022-09-12 Journal: Advanced Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 alteration Ang II angiotensin-converting enzyme 2 Cardiomyocytes chromatin cleavage complex connexin Culture damage downregulated Effect endocytic expression fluctuation functional hiPSC host cells incubated investigated margination molecular pluripotent stem cell Protein Proteins receptor SARS-CoV-2 spike Spike protein Spike proteins Structure subunit the spike protein undergo virus while [DOI] 10.1002/adbi.202101327 PMC 바로가기 [Article Type] Article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine StimulationDiscovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.Article Published on 2022-07-012022-09-11 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon [DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
Electrostatic Map of the SARS-CoV-2 Virion Specifies Binding Sites of the Antiviral Cationic PhotosensitizerSARS-CoV-2 Virion의 정전기 지도는 항바이러스 양이온 광감작제의 결합 부위를 지정합니다Article Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] antibodies Antiviral Brownian dynamics coarse-grain model component computational method different materials distribution domain drugs E protein electrostatic electrostatic interactions Electrostatics Glutamate glutamate residue groups heterogeneous host cells Interaction Lipid lipids Map Numerous oxygen photosensitizer phthalocyanine positive Positive Charge predict Protein Proteins Reactions reactive oxygen SARS-CoV-2 Site Structure target the SARS-CoV-2 understanding viral envelope viral membrane virion virus Zinc [DOI] 10.3390/ijms23137304 PMC 바로가기 [Article Type] Article