Protein(18) SARS-CoV-2(13) proteome(13) Infection(11) post-translational modification(11) mass spectrometry(10) robust(10) COVID-19(10) proteomics(10) proteomic(9) viral infection(9) plasma(9) develop(8) provide(8) globe(8) virus(8) shown(7) COVID-19, Coronavirus disease 2019(7) predict(7) expression(7) COVID-19 patient(7) host response(7) coronavirus(7) Analysis(7) Treatment(7) disease severity(7) Factor(7) FIVE(7) Proteins(7) pandemic(7)
Open Modification Searching of SARS-CoV-2-Human Protein Interaction Data Reveals Novel Viral Modification Sites
Article
[키워드] open modification searching
Phosphorylation
post-translational modification
protein–protein interactions
S-nitrosylation
SARS-CoV-2
ubiquitination.
[DOI] 10.1016/j.mcpro.2022.100425 PMC 바로가기
[DOI] 10.1016/j.mcpro.2022.100425 PMC 바로가기
Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning
Research article
Published on
Journal: Molecular & Cellular Proteomics : MCP
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
Journal: Molecular & Cellular Proteomics : MCP
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
[키워드] BSAbovine serum albumin COVID-19
Dickinson and Company
3-nitrophenylhydrazine
AAAamino acid analysis
Accuracy
ACDacid citrate dextrose
acetonitrile
acid citrate dextrose
ACNacetonitrile
Alpha 1-antichymotrypsin
Alpha-1-antichymotrypsin
amino acid analysis
analysis of variance
ANOVAanalysis of variance
APCS
APOA2
APOA4
APOH Beta-2-glycoprotein 1
Apolipoprotein A-IIAPOA4
Apolipoprotein A-IVAPOH Beta-2-glycoprotein 1
area under the curve
AUC
AUCarea under the curve
B2MBeta-2-microglobulin
BDBecton
Becton
Beta-2-microglobulin
BHTbutylated hydroxyl toluene
bovine serum albumin COVID-19
BQC19
building
butylated hydroxyl toluene
C-reactive protein
C1RLComplement C1r subcomponent-like protein
C2Complement C2
C3Complement C3
C4AComplement C4
C4b-binding protein alpha chain
C4BPAC4b-binding protein alpha chain
C5Complement C5
C7Complement C7
C9Complement C9
CAMPCathelicidin antimicrobial peptide
capillary zone electrophoresis
Carboxypeptidase B2
Cathelicidin antimicrobial peptide
CFBComplement factor B
CFHComplement factor H
Clinical Proteomic Tumor Analysis Consortium
Coagulation factor XIII A chain
Complement C1r subcomponent-like protein
Complement C2
Complement C3
Complement C4
Complement C5
Complement C7
Complement C9
Complement factor B
Complement factor H
Concentration
concentrations
Control
COVID-19 hospitalization
COVID-19 patient
CPB2Carboxypeptidase B2
CPTACClinical Proteomic Tumor Analysis Consortium
CRPC-reactive protein
CST3Cystatin-C
Cystatin-C
CZEcapillary zone electrophoresis
disease severity
dithiothreitol
DTTdithiothreitol
ECMOextracorporeal membrane oxygenation
extracorporeal membrane oxygenation
F13A1Coagulation factor XIII A chain
FAFormic acid
false discovery rate
FDRfalse discovery rate
FGAFibrinogen alpha chain
FGBFibrinogen beta chain
FGGFibrinogen gamma chain
Fibrinogen alpha chain
Fibrinogen beta chain
Fibrinogen gamma chain
FIVE
Formic acid
Gelsolin
Gene name /Protein nameAPCS
globe
GSNGelsolin
haptoglobin
Healthcare system
Heparin cofactor 2
Hospitalization
hospitalized COVID-19 patients
HPhaptoglobin
IAAiodoacetamide
ICUIntensive Care Unit
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit
Insulin-like growth factor-binding protein complex acid labile subunit
intensive care unit
Inter-alpha-trypsin inhibitor heavy chain H2
Inter-alpha-trypsin inhibitor heavy chain H4
iodoacetamide
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4
K3EDTAtripotassium ethylenediaminetetraacetic acid
L-(tosylamido-2-phenyl) ethyl chloromethyl ketoneTrisHCl
LC-MSliquid chromatography-mass spectrometry
LC/MRM-MSliquid chromatography/multiple reaction monitoring mass spectrometry
Leucine-rich alpha-2-glycoprotein
liquid chromatography-mass spectrometry
liquid chromatography/multiple reaction monitoring mass spectrometry
LLOQLower Limit of Quantitation
Lower Limit of Quantitation
LRG1Leucine-rich alpha-2-glycoprotein
lysoPClysophosphatidylcholine
lysophosphatidylcholine
MALDImatrix assisted laser desorption ionization
mass spectrometry
matrix assisted laser desorption ionization
MeOHmethanol
metabolite
methanol
Mortality
MSmass spectrometry
N-acetylmuramoyl-L-alanine amidase
Neuropilin-2
Non-survivors
NPH3-nitrophenylhydrazine
NRP2Neuropilin-2
patient survival
PBSPhosphatase buffered saline
PCAprincipal component analysis
PCRpolymerase chain reaction
PGLYRP2N-acetylmuramoyl-L-alanine amidase
phenylisothiocyanate
Phosphatase buffered saline
PITCphenylisothiocyanate
plasma
polymerase chain reaction
post-translational modification
predict
Predictive
PRG4Proteoglycan 4
principal component analysis
PROS1Vitamin K-dependent protein S
Protein
Proteoglycan 4
PTMpost-translational modification
QCquality control
Quality control
reversed phase ultrahigh performance liquid chromatography
robust
RP-UHPLCreversed phase ultrahigh performance liquid chromatography
SAA2Serum amyloid A-1 and A-2 proteins
SAA4Serum amyloid A-4 protein
SARS-CoV-2SIS
Scientific and Cultural Organization
Sequential Organ Failure AssessmentSPE
SERPINA1Alpha-1-antichymotrypsin
SERPINA3Alpha 1-antichymotrypsin
SERPIND1Heparin cofactor 2
Serum amyloid A-1 and A-2 proteins
Serum amyloid A-4 protein
Serum amyloid P-componentAPOA2
significant difference
SIS
SOFA
solid-phase extractionSVM
SPE
stable-isotope labeled internal standardSOFA
Stratification
Support Vector MachineTPCK
survival
survivor
SVM
The Universal Protein Resource
TPCK
Transthyretin
Treatment
tripotassium ethylenediaminetetraacetic acid
Tris (hydroxymethyl) aminomethane hydrochlorideUNESCO
TrisHCl
TTRTransthyretin
UNESCO
UniProtThe Universal Protein Resource
unique
United Nations EducationalScientific and Cultural Organization
Vascular cell adhesion protein 1
VCAM1Vascular cell adhesion protein 1
Vitamin K-dependent protein S
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation
Discovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.
Article
Published on
Journal: Molecular & Cellular Proteomics : MCP
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,
Journal: Molecular & Cellular Proteomics : MCP
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,
[키워드] activated
AKT
Antiviral
approach
autocrine
BRAF
c-MYC
Cancer
cancer cell line
cancer cell lines
cancers
Cell
cell line
cellular
DDX58
develop
double-stranded
double-stranded RNA
downregulation
driven by
driving
dsRNA
EGFR
expression
functional
hallmark
HER2
immune evasion
Infection
interferon
KRAS
lower expression
MEK
molecular
MYC
OAS
oncogene
oncogenes.
oncogenic
osteosarcoma
Pancreatic cancer
phenotypic
profiles
Protein
Proteins
proteome
provide
reduced
regulated
response
RIG-I
RNA virus
SARS-CoV-2
shown
Stimulation
susceptibility
susceptibility to infection
therapeutic
treated
type 1 interferon
[DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis
Research article
[키워드] antibody
automated
Biomarker
contribute
disease
disease severity
immunoassay
information
knowledge
multiplex
Next-generation sequencing
Patient
plasma
Precision
Prognosis
progression
Protein
proteome
proteomics
proximity extension assay
Sequencing
serum
Stratification
translate
understanding
unique
[DOI] 10.1016/j.mcpro.2021.100168 [Article Type] Research article
[DOI] 10.1016/j.mcpro.2021.100168 [Article Type] Research article
Uncovering the Depths of the Human Proteome: Antibody-based Technologies for Ultrasensitive Multiplexed Protein Detection and Quantification
Review article
[키워드] antibody array
antibody microarray
aptamer
biofluid
Biomarker
Comparisons
complement
Concentration
cross talk
Depth
detection
disadvantage
disease
drug target discovery
Human
immunoassays
knowledge
mechanisms
multiplex
plasma
Probing
Protein
Proteins
proteome
proteomics
proximity extension assay
quantification
recent
researcher
single-molecule array
technology
technology advances
technology comparison
tissue
[DOI] 10.1016/j.mcpro.2021.100155 [Article Type] Review article
[DOI] 10.1016/j.mcpro.2021.100155 [Article Type] Review article
Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx
비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명
Research
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
addition
AGC, automatic gain control
airway
AKT
Analysis
antiviral property
antiviral signaling
asymptomatic infection
caused
CEP131
CFAP57
characterized
ciliary
component
components
confirmed COVID-19 case
controls
coronavirus
coronavirus disease
Coronavirus disease 2019
Coronavirus infections
COVID-19
COVID-19 severity
COVID-19, Coronavirus disease 2019
CXCL10
downregulation
dysregulated immune response
dysregulation
E3 ubiquitin ligases
FDR, false discovery rate
Health
High-resolution
host response
humans
IFN, interferon
immune response
implicated
infected individual
infected individuals
Infection
Inflammatory response
interferon
interferon-stimulated gene
interferon-stimulated genes
investigator
investigators
involved
ISG15
ISGs, interferon-stimulated genes
mechanism
MERS-CoV, Middle East respiratory syndrome coronavirus
molecular
MPB, mobile phase B
multiorgan disease
MX1
nasopharyngeal swabs
negative control
negative controls
NHBE, normal human bronchial epithelial
novel
NP, nasopharyngeal
OGFR, opioid growth factor receptor
OPRPN, Opiorphin prepropeptide
pandemic
Pathogenesis
pathogenesis of COVID-19
Pathways
performed
phosphoproteome
Phosphoproteomics
Phosphorylation
PKC
PPIase, peptidyl-prolyl cis /trans isomerase
PRM, parallel reaction monitoring
proteasomal
Protein
protein synthesis
proteomic
Proteomic analysis
proteomics
PRRs, pathogen-recognition receptors
respiratory
response
RIG-I
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
severe acute respiratory syndrome Coronavirus
shown
signaling pathway
signature
Stat1
subunits
Swab
These data
upper airway
upregulated
upregulation
valuable resource
Viral
viral entry
viral infection
viral infections
virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research
Proteome Profiling of Recombinant DNase Therapy in Reducing NETs and Aiding Recovery in COVID-19 Patients
Research
[키워드] Abstract
accumulation
acute respiratory distress
Adverse reaction
AF, Alexa Fluor
airway
airways
analyses
Analysis
analysis
approved
ARDS, acute respiratory distress syndrome
blood plasma
CF, cystic fibrosis
change
clinically
components
contribute
coronavirus disease
COT, conventional oxygen therapy
COVID-19
COVID-19 disease
COVID-19, Coronavirus disease 2019
DAPI, 4,6 diamidino-2-phenylindole
DIA-MS, data-independent acquisition MS
DNA
DNase
ECMO, extracorporeal membrane oxygen therapy
extracellular DNA
FDR, false discovery rate
FiO2, fraction of inspired oxygen
FIVE
GGO, glass ground opacity
hallmark
hemorrhage
HFNO, high-flow nasal oxygenation
high-flow oxygen therapy
hindrance
Hypoxemia
immunofluorescence
implication
IMPROVE
infections
Inflammation
iRT, indexed retention time peptides
Lung function
mass spectrometry
Microscopy
NE, neutrophil elastase
NET
NET, neutrophil extracellular trap
NETs
Neutrophil extracellular trap
oxygen saturation
Oxygenation
PADI-4, peptidyl arginine deiminase IV
Patient
patients
plasma
Pneumonia
Profiling
proteome
pulmonary inflammation
Quantitative
recombinant
reduce
reduced
reducing
reduction
Respiratory failure
rhDNase, recombinant human DNase I
Roche
SARS-CoV2, severe acute respiratory syndrome coronavirus 2
severe COVID-19 patient
severe COVID-19 patients
Severe patient
severely ill patient
shown
SpO2, the oxygen saturation as measured by pulse oximetry
sputum
statistically significant
Symptom
syndrome
systemic inflammatory
targeting
the disease
therapeutic
therapy
treated
Treatment
with COVID-19
[DOI] 10.1016/j.mcpro.2021.100113 PMC 바로가기 [Article Type] Research
[DOI] 10.1016/j.mcpro.2021.100113 PMC 바로가기 [Article Type] Research
Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research
SARS-CoV-2 매개 COVID-19 팬데믹에 대한 Proteomics 기반 통찰력: 연구 첫해에 대한 검토
Review
[키워드] ACE2, angiotensin-converting enzyme 2
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
antibody
article
Betacoronavirus
biological system
Biomarker
Biomarkers
caused
China
CK2, casein kinase II
Community
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 pandemic
COVID-19, Coronavirus disease 2019
DDA, data-dependent acquisition
death
develop
Diagnosis
effort
evidenced
Factor
feature
focus
Genome
genome sequence
glycome
glycosylation
Health
help
Host
host cell
host response
human disease
immune system
Infection
information
initial
insight
Interaction
MS
NSP, nonstructural protein
pandemic
peer-reviewed
Perspective
PIKFyve, a FYVE finger–containing phosphoinositide kinase
post-translational modification
post-translational modifications
PPI, protein–protein interaction
PRM, parallel reaction monitoring
probe
Protein–protein interaction
protein–protein interactions
proteome
proteomic
proteomic study
proteomics
provide
PTM, post-translational modification
qPCR, quantitative PCR
Qualitative
Quantitative
respiratory
responses
review
robust
SARS-CoV-2
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
selected
severe acute respiratory syndrome Coronavirus
the disease
Therapies
tissue
TMPRSS2, Transmembrane serine protease 2
TMT, tandem mass tag
Transmissibility
Viral
viral infection
virulence
virus
worldwide pandemic
Year
[DOI] 10.1016/j.mcpro.2021.100103 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.mcpro.2021.100103 PMC 바로가기 [Article Type] Review
Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run
단일 실행에서 100개 항체의 항체 결합 에피토프 매핑(AbMap)
Article
[키워드] antibody
binding
binding epitope
conformational
convalescent serum
COVID-19
COVID-19 patient
defined
diagnostics
epitope
epitope mapping
functional
information
less
linear
linear epitope
magnitude
mapping
Next-generation sequencing
peptide
phage display
profile
PROTECT
random
random peptide library.
specific antibody
Spike protein
the antibodies
[DOI] 10.1074/mcp.RA120.002314 PMC 바로가기 [Article Type] Article
[DOI] 10.1074/mcp.RA120.002314 PMC 바로가기 [Article Type] Article