In late 2019, a virus subsequently named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and led to a worldwide pandemic of the disease termed coronavirus disease 2019. The global health threat posed by this pandemic led to an extremely rapid and robust mobilization of the scientific and medical communities as evidenced by the publication of more than 10,000 peer-reviewed articles and thousands of preprints in the first year of the pandemic alone. With the publication of the initial genome sequence of SARS-CoV-2, the proteomics community immediately joined this effort publishing, to date, more than 100 peer-reviewed proteomics studies and submitting many more preprints to preprint servers. In this review, we focus on peer-reviewed articles published on the proteome, glycoproteome, and glycome of SARS-CoV-2. At a basic level, proteomic studies provide valuable information on quantitative aspects of viral infection course; information on the identities, sites, and microheterogeneity of post-translational modifications; and, information on protein–protein interactions. At a biological systems level, these studies elucidate host cell and tissue responses, characterize antibodies and other immune system factors in infection, suggest biomarkers that may be useful for diagnosis and disease-course monitoring, and help in the development or repurposing of potential therapeutics. Here, we summarize results from selected early studies to provide a perspective on the current rapidly evolving literature. Graphical Abstract Highlights • SARS-CoV-2, which caused the COVID-19 pandemic, depends on features of its proteome and host proteomes for transmissibility and virulence. • Qualitative and quantitative proteomic assay development underlies attempts to further understand the virus. • Protein–protein interaction and post-translational modification studies inform efforts to develop therapies. • In sum, the range of proteomics technologies provides valuable information in the fight against COVID-19. In Brief SARS-CoV-2, the betacoronavirus that caused the COVID-19 pandemic, became a major source of human disease and death in 2020. The fundamental constituents of a virus being its genome and proteome, characterizing the proteome is essential to understanding its biology. In this review article, we survey the proteomics literature from the first year of the COVID-19 pandemic, including protein–protein interaction studies, post-translational modification studies, and work using proteomics technologies to probe host response, which collectively inform efforts to ameliorate the pandemic.
【저자키워드】 COVID-19, SARS-CoV-2, review, glycosylation, COVID-19, Coronavirus disease 2019, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, ACE2, angiotensin-converting enzyme 2, MS, TMPRSS2, Transmembrane serine protease 2, NSP, nonstructural protein, CK2, casein kinase II, DDA, data-dependent acquisition, PIKFyve, a FYVE finger–containing phosphoinositide kinase, PPI, protein–protein interaction, PRM, parallel reaction monitoring, PTM, post-translational modification, qPCR, quantitative PCR, TMT, tandem mass tag, 【초록키워드】 coronavirus disease, viral infection, proteomics, Coronavirus disease 2019, coronavirus, pandemic, Biomarker, Biomarkers, antibody, COVID-19 pandemic, Genome, Infection, Diagnosis, host response, immune system, severe acute respiratory syndrome Coronavirus, virus, Betacoronavirus, China, Health, Viral, Transmissibility, death, Qualitative, Community, proteome, respiratory, information, virulence, Quantitative, proteomic, Therapies, post-translational modifications, Protein–protein interaction, Interaction, genome sequence, protein–protein interactions, focus, host cell, post-translational modification, acute respiratory syndrome, Factor, acute respiratory syndrome coronavirus, human disease, tissue, acute respiratory syndrome coronavirus 2, Perspective, worldwide pandemic, help, effort, article, glycome, probe, Host, responses, feature, proteomic study, robust, initial, selected, develop, caused, the disease, provide, evidenced, peer-reviewed, biological system, 【제목키워드】 insight, Year,