Metformin Use Is Associated with Decreased Mortality in COVID-19 Patients with Diabetes: Evidence from Retrospective Studies and Biological MechanismArticle Published on 2021-08-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval acute lung damage Anti-inflammatory article articles Asia association Biological carried collected coronavirus disease COVID-19 COVID-19 patients database Decreased diabete diabetes Effectiveness endothelial damage Europe Evidence heterogeneity hyperglycemia hyperinflammatory state immunosuppressive effects inclusion criteria Inconclusive increase independent information insulin investigated Meta-analysis metformin Mortality mortality rate North America participant Patient patients with COVID-19 previous study random-effects model reduced risk reducing risk risk ratio RRs selected severity shown significantly subgroup analysis Support the patient Treatment Trial type 2 diabete Vascular was used Web of Science [DOI] 10.3390/jcm10163507 PMC 바로가기 [Article Type] Article
Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort studyObservational Study Published on 2021-08-012022-10-04 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상, [키워드] 95% CI 95% CIs accompanied Advancing age Analysis Asian association Autoimmune black body-mass Cancer cause chronic heart disease Chronic kidney disease chronic liver disease chronic respiratory disease Cohort Comorbidities Comorbidity COVID-19 mortality COVID-19 pandemic death diabetes disease effective excluded exclusion Factor finding FIVE Follow-up foundation funding greater groups heart hypertension incidence rate increased risk individuals Infection Infectious disease Inflammatory Male sex median Mortality Multimorbidity Neurological disease non-specific obesity Observational cohort study occurred outcome measure participant Poisson regression model prevalent Psychiatric psychiatric disorder recruitment reduced risk repeated replaced reported Research Respiratory disease rheumatological risk factor risk of death risk of infection Separate Sex smoking smoking status sociodemographic factors Socioeconomic deprivation stroke subset to define UK biobank used data white with COVID-19 [DOI] 10.1016/S1473-3099(20)30978-6 PMC 바로가기 [Article Type] Observational Study
Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort studyResearch Paper Published on 2021-07-312022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] 95% CI activated acute respiratory syndrome adjusted adjusted odds ratio Africa African age association body mass index clinical Clinical presentations Co-infection Comorbidities coronavirus correlation COVID-19 COVID-19 patient COVID-19 severity death Developing Effect endemic area enrolled Entamoeba Ethiopian European hyper-inflammation Hypothesis immune system immunomodulatory indicate Infection intestinal Joep Lange less logistic regression model Model Netherlands parasite parasite infections parasites partnership Patient patients positive Primary outcome Probability proportion prospective observational cohort Protozoa reduced risk response SARS-CoV-2 SARS-CoV-2 infected patient Schistosoma mansoni screened severe COVID-19 severe COVID-19 patient severity Sex significantly stratified Symptom Trichuris trichiura union were used with COVID-19 [DOI] 10.1016/j.eclinm.2021.101054 PMC 바로가기 [Article Type] Research Paper
Prevalence and correlates of psychological distress amongst healthcare workers during the COVID-19 pandemic: An online surveyOriginal Research Published on 2021-07-292022-10-29 Journal: The South African Journal of Psychiatry : SAJP : the Journal of the Society of Psychiatrists of South Africa [Category] COVID-19, [키워드] analysed carried chi-square test conducted Contact coronavirus disease COVID-19 COVID-19 pandemic cross-sectional determine female finding general health questionnaire-12 (GHQ-12), pandemic Google had no healthcare healthcare worker Healthcare workers knowledge Logistic regression male mental health Nigeria pandemic positive patient positive patients Prevalence Protective Psychological distress Quantitative questionnaire reduced risk reported Result risk Self-report questionnaires setting socio-demographic understanding variables WhatsApp with COVID-19 [DOI] 10.4102/sajpsychiatry.v27i0.1617 PMC 바로가기 [Article Type] Original Research
Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease RegistryResearch Article Published on 2021-07-152022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% CI adjusted odds ratio Admission analyses Anti-inflammatory association cardiovascular coronavirus disease COVID-19 CVD death demographic characteristics discharge enrolled evaluate finding heart hospital Hospitalization hypertension immunomodulatory effect indicated individual Logistic regression Medical conditions medication observation occurred organ dysfunction outcome outcomes Outpatient Patient patients hospitalized Population reduce reduced risk reduction in registry relation risk severe inflammation severity Severity of disease statin statistically significant subject Support therapy Treatment used data with COVID-19 [DOI] 10.1371/journal.pone.0254635 PMC 바로가기 [Article Type] Research Article
Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapiesResearch Published on 2021-07-132022-10-31 Journal: Diabetology & Metabolic Syndrome [Category] COVID-19, [키워드] Analysis Brazil chloroquine/hydroxychloroquine clinical condition Cohort Comorbidity COVID-19 death diabete diabetes evaluate evaluated group high risk Hospital admission Hospitalization In-hospital increased mortality indicated intubation metformin Mortality older patient outcome parameter Patient patients patients hospitalized Prognosis proportion receiving reduced reduced risk Result risk risk factor severity shown significantly single-center study stroke supplementary material survival therapy Treatment univariable with COVID-19 [DOI] 10.1186/s13098-021-00695-8 PMC 바로가기 [Article Type] Research
Socio-Demographic Factors Involved in a Low-Incidence Phase of SARS-CoV-2 Spread in Sicily, ItalyArticle Published on 2021-07-092022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] 95% CI analysed analyses Asymptomatic census section clinical outcomes collected Deceased evaluated Factor FIVE Follow-up groups high risk incidence Infection investigated Italy male mild case multivariable analysis outcomes Patient phase predictor Prevalence reduced risk risk SARS-CoV-2 Sex Sicily social determinant socio-demographic socio-demographic factors virus spread virus transmission [DOI] 10.3390/healthcare9070867 PMC 바로가기 [Article Type] Article
Mental Health Crisis and Stress Coping among Healthcare College Students Momentarily Displaced from Their Campus Community Because of COVID-19 Restrictions in JapanArticle Published on 2021-07-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] activities activity affected Anxiety Campus Characteristics college conducted coping Coping strategy COVID-19 COVID-19 pandemic crisis cross-sectional survey declined Good group Health status healthcare healthcare college students identify Isolation Japan loneliness mental health mental health problems poor mental health questionnaire reduced risk restriction risk risk factor Satisfaction self-quarantine Stress stress coping student Support [DOI] 10.3390/ijerph18147245 PMC 바로가기 [Article Type] Article
SAVER: sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia—a phase II randomised control trial study protocolSaver : 고위험 경구 상피의 후성 재 프로그래밍을위한 나트륨 valproate-2 상 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-07-052022-09-01 Journal: Trials [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 진단, [키워드] acceptability adverse effects Blood blood sample Blood samples cancer development Chemoprevention childbearing potential clinical collected Compliance Diagnosis Drug repurposing dysplasia Effect Endpoint Epigenetic Epigenetic reprogramming epithelial European Evidence evidence of excluded feasibility GRADE IIb include lead lesion size malignancy management medication notable observation Open-label oral cancer Oral epithelial dysplasia outcome Patient Perception preliminary evidence Primary outcome protective mechanism provide randomisation randomised randomised controlled trial recruited recruitment reduced risk reduction in regions Registered risk secondary care sodium Sodium valproate Study protocol subsequent supplementary material surgery surgical resection Surveillance targets teratogenic Trial Trial registration Valproate [DOI] 10.1186/s13063-021-05373-8 PMC 바로가기 [Article Type] Study Protocol
Factors preventing SARS-CoV-2 transmission during unintentional exposure in a GP practice: a cohort study of patient contacts; Germany, 2020Special Collection Question Published on 2021-07-022022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI calculated Cohort cohort of patient cohort study confirmed cases Contact Contact tracing COVID-19 COVID-19 case COVID-19 cases determinant Evidence Factor Frequency Germany incidence rate joint laboratory confirmation local public health measure outbreak Patient Patient care patients Practitioner preventing the transmission provided recruited reduced risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission symptom onset unintentional exposure [DOI] 10.1017/S0950268821001503 PMC 바로가기 [Article Type] Special Collection Question