Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donorsCOVID-19 회복기 혈장으로 치료받은 개인의 사망률은 기증자의 지리적 출처에 따라 다릅니다.Article Published on 2021-08-112022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, 치료제, [키워드] access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect antigenic applied Clinical studies convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatments COVID-19 vaccine COVID-19 vaccines death defined develop Donor effective Effectiveness Efficacy Expanded access Hypothesis immune response immunological Immunotherapy implication individual Interpretation Local Patient plasma reflect Regional respiratory Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Support transfusion treated Treatment Treatment outcome Vaccine Vaccines variant viral infection viral strains with COVID-19 [DOI] 10.1038/s41467-021-25113-5 PMC 바로가기 [Article Type] Article
A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable LiteraturePharmacology Published on 2021-08-112022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] administration antagonist action approach approaches clinical trial clinician Confusion Course COVID-19 disease ontology dosage drug Drug discovery experimental design Famotidine histamine (H2) receptor IMPROVE independent information knowledge Knowledge graph literature Meta-analysis methodological ontological outcome placebo-controlled potential benefit Randomized reflect regimen reported resolved retrospective Retrospective study statistical analysis Stratification therapeutic indications turn utility Validity Variability variable [DOI] 10.3389/fphar.2021.700703 PMC 바로가기 [Article Type] Pharmacology
The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients사이토카인 HGF와 CXCL13은 코로나19 환자의 중증도와 사망률을 예측한다Article Published on 2021-08-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Admission anti-inflammatory properties anti-inflammatory property association B cell response best cellular chemokine Cohort cohorts Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL13 cytokine Cytokines death fibrosis Follow-up French hepatocyte growth factor HGF Host immune response ICU ICU admission identify immunological inflammatory pathways intensive care intensive care unit investigated Ligand likelihood Lung fibrosis lung tissue marker maturation mechanism Mortality motif Negative predictive value non-ICU non-ICU patients Occurrence over Patient patients pleiotropic positive power predict Predictive predictive values Prevent pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines pulmonary fibrosis reflect SARS-CoV-2 severe coronavirus disease severity significantly university up-regulation viral infection [DOI] 10.1038/s41467-021-25191-5 PMC 바로가기 [Article Type] Article
Characteristics of COVID-19-Related Free Telephone Consultations by Public Health Nurses in Japan: A Retrospective StudyArticle Published on 2021-08-092022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] analyzed Characteristics city Community consultation coronavirus disease COVID-19 COVID-19 symptoms First wave Free information Japan no difference Nurse organization PCR PCR testing primary care Public public health public health nurse recorded reflect Sex telephone telephone consultation [DOI] 10.3390/healthcare9081022 PMC 바로가기 [Article Type] Article
Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range비강 점막의 면역 세포 거주는 연령대의 호흡기 질환 심각성을 부분적으로 설명 할 수 있습니다.Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adults age analyzed antiviral properties applied Cell cell type cellular changes in children correlated COVID-19 severity epigenome epithelial cell epithelial cells Evidence explain Functional genomics generate healthy individual healthy individuals immune immune activation Immune cell immune cell type immunization strategies individual infection with SARS-CoV-2 innate immune response innate immune system Mucosal immunology nasal nasal mucosa Previous studies previous study proportion reflect resource respiratory Respiratory disease respiratory infection robust SARS-CoV-2 Sequencing severity Single-cell RNA-sequencing suggested T cell transcriptional underlie uninfected [DOI] 10.1038/s41598-021-95532-3 PMC 바로가기 [Article Type] Article
A Novel Saliva RT-LAMP Workflow for Rapid Identification of COVID-19 Cases and Restraining Viral SpreadArticle Published on 2021-08-032022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 2019 novel coronavirus age Analysis associations clinical COVID-19 COVID-19 transmission Decline decrease develop diagnostics evaluate female females Gender identification information isothermal amplification LAMP (loop-mediated isothermal amplification) assay males novel onset of symptoms performed protocols Rapid reflect Restraining reveal reverse transcription RT-LAMP RT-PCR Saliva SARS-CoV-2 transmission sensitivity specificity specimen specimens Symptom symptom onset symptomatic patient Transmission Transmission dynamics Viral detection viral diagnostics Viral load viral spread was determined were used [DOI] 10.3390/diagnostics11081400 PMC 바로가기 [Article Type] Article
Repeated cross-sectional analysis of hydroxychloroquine deimplementation in the AHA COVID-19 CVD RegistryArticle Published on 2021-07-232022-10-04 Journal: Scientific Reports [Category] 임상, [키워드] AHA benefit clinical care clinical information COVID-19 cross-sectional analysis CVD hospital Hydroxychloroquine IQR median National offer Patient peaked proportion Psychology and behaviour randomized trial rapid response receiving reflect registry therapy therapy for COVID-19 use of hydroxychloroquine viral infection [DOI] 10.1038/s41598-021-94203-7 PMC 바로가기 [Article Type] Article
Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank더 짧은 백혈구 텔로미어 길이는 부정적인 COVID-19 결과와 관련이 있습니다: UK Biobank의 코호트 연구Research Paper Published on 2021-07-232022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 95% CI adjusted age Analysis association Biological Biotechnology Causality cohort study collider bias Community Composite conducted coronavirus coronavirus disease Coronavirus disease-19 Council COVID-19 Critical care defined determine Ethnicity evaluate exploratory finding foundation funding genetic variants heart higher risk Hospital admission independent independent of infection with SARS-CoV-2 information leucocyte leukocyte marker Medical Research Council Mortality MR analyses Odds ratio outcome outcomes participant positive randomisation recorded recruited reduced reflect respiratory Respiratory Support risk risk factor Science Sex tested UK biobank UKB with COVID-19 [DOI] 10.1016/j.ebiom.2021.103485 PMC 바로가기 [Article Type] Research Paper
Stochastic model for COVID-19 in slums: interaction between biology and public policiesOriginal Paper Published on 2021-07-212022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] ad-hoc bimodal change Characteristics coronavirus disease COVID-19 database detection efficiency disease Efficiency Epidemic Evolution high variability Hypothesis implementation Interaction Intervention Isolation Markov-jump process mathematical modulation outbreak Outbreaks parameter progression recorded reflect reported representing Requesting stochastic stochastic compartmental model surveillance protocols Symptom the timing Viraemia viraemic levels [DOI] 10.1017/S0950268821001746 PMC 바로가기 [Article Type] Original Paper
Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function Reviews Published on 2021-07-192022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] Anti-inflammatory approach association attenuate cardiovascular disease cells chronic Chronic kidney disease circulating CKD Complication Cytokines diabetes Diabetes Mellitus fatty Fatty acid glucose tolerance highlight homeostasis hydroxy hypertension Immune cell Inflammation Inflammatory response initial Injury insulin resistance Interaction kidney Kidney function leukocytes Lipid lipid mediator low-grade inflammation mechanism metabolic dysfunction metabolism obesity parenchymal pathogenic Pathways peptides pro-inflammatory mediator promote recruitment reflect risk factor therapeutic intervention [DOI] 10.1038/s41581-021-00454-y [Article Type] Reviews