The Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program: protocol for a two-arm parallel partially nested randomized controlled feasibility trial with progression to full-scale trial경피증 환자 중심 중재 네트워크 자가 관리(SPIN-SELF) 프로그램: 전체 규모 시험으로 진행되는 2군 병렬 부분적으로 중첩된 무작위 통제 실행 가능성 시험을 위한 프로토콜Study Protocol Published on 2021-11-272022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 Activation addition Anxiety Autoimmune charge chronic chronic disease Cohort connective tissue connective tissue disease criteria determine disease disseminate E-health Eligible participants evaluate the effect feasibility functional health IMPROVE include initial Intervention management managing media meeting moderate disease modifications network offer organization organizations outcome participant Patient Patient activation Primary outcome proceed Program progression protocol randomization Randomized Randomized controlled trial RCT recruited scale Scleroderma secondary Secondary outcomes Self-efficacy Self-management social media Spin stoppage supplementary material systemic Systemic sclerosis Trial Trial registration two-arm parallel usual care [DOI] 10.1186/s13063-021-05827-z PMC 바로가기 [Article Type] Study Protocol
Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort studyResearch Published on 2021-11-262022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory distress Admission age Analysis ARDS benefit Clinical effect cohort study collected data competing conducted Corticosteroid corticosteroid treatment Corticosteroids COVID-19 COVID-19-associated acute respiratory distress syndrome COVID-19-associated ARDS Effect Effectiveness hospital ICU ICU admission identify in-hospital mortality individual intensive care intensive care unit Invasive mechanical ventilation mechanically ventilated Mortality multicentre no significant difference non-survivor not differ outcome Patient patients patients treated performed propensity score matching question required Research Result Retrospective study risk secondary Secondary outcomes sensitivity analysis severe ARDS severe coronavirus disease Shock short-term survival Spanish Specific subgroup supplementary material survival syndrome Tocilizumab Treatment untreated patient ventilator-free day were excluded [DOI] 10.1186/s13613-021-00951-0 PMC 바로가기 [Article Type] Research
Kukaa Salama (Staying Safe): study protocol for a pre/post-trial of an interactive mHealth intervention for increasing COVID-19 prevention practices with urban refugee youth in Kampala, UgandaKukaa Salama(안전 유지): 우간다 캄팔라에서 도시 난민 청소년을 대상으로 COVID-19 예방 관행을 늘리기 위한 양방향 mHealth 개입의 사전/사후 시험을 위한 연구 프로토콜Article Published on 2021-11-222022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] approved board Cluster collected condition Council COVID-19 COVID-19 mitigation COVID-19 vaccine Descriptive statistics Effectiveness enrolled Ethics ethics committee evaluate evaluated Follow-up food hand washing Health Intervention Measures mHealth intervention Mobile health participant peer-reviewed physical distancing poverty Preventive medicine Primary outcome public health Randomised trial refugee registration number registry Regression analyses reproductive Research Ethics response risk Science secondary outcome Secondary outcomes Self-efficacy Study protocol sub-Saharan Africa technology Toronto Uganda university water Youth [DOI] 10.1136/bmjopen-2021-055530 PMC 바로가기 [Article Type] Article
‘Dove Confident Me Indonesia: Single Session’: study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents‘인도네시아에 확신을 갖고있다 : 단일 세션’: 인도네시아 청소년들 사이에서 학교 기반 신체 이미지 개입을 평가하기위한 무작위 통제 시험을위한 연구 프로토콜Study Protocol Published on 2021-11-162022-09-10 Journal: BMC Public Health [Category] MERS, SARS, 임상, 치료기술, [키워드] acceptability activities Adolescent mental health approval attrition baseline Body image Cluster collected Comparisons conducted Confident consequence country COVID-19 pandemic detect develop East education effective Effectiveness engage Engagement England Ethical approval evaluate evaluated Follow-up Guidance Health highlighting implementation IMPROVE Indonesia Intervention Intervention effects lack life Life skills education limitation Low- and middle-income countries medium minimum mood outcome participant plan post-intervention Prevalence Primary outcome promise promote protocol qualitative data questionnaire randomised controlled trial reducing Satisfaction School School-based intervention secondary Secondary outcomes Self-report questionnaires Single-session intervention skill Southeast Asia Study design Study protocol supplementary material tendency Trial university West [DOI] 10.1186/s12889-021-11770-0 PMC 바로가기 [Article Type] Study Protocol
CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults촉매 시험 프로토콜 : 입원 성인의 COVID-19에 대한 잠재적 치료의 초기 및 가속 평가를위한 멀티 센터, 오픈 라벨, 2 단계, 다중 암 시험.Intensive Care Published on 2021-11-112022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 임상, [키워드] accelerated Admission adult intensive & critical care Analysis approval approved Biomarker C reactive protein candidate drugs chest X-ray clinical clinical picture COVID-19 CRP CT scan death dissemination dysregulated immune response East Efficacy eligible Ethics ethics committee Evidence evidence of hospital discharge hospitalised Hospitalised patients identify immunomodulation IMPROVE improvement include Infectious diseases inflammatory monocyte inflammatory monocytes initial International Macrophage macrophages MHRA Monocytes multicentre National Open-label outcome Patient peer-reviewed platform Platform trial Pneumonia positive Potential treatment primary outcome measure proinflammatory protocol public health registration numbers Research Ethics reverse transcription PCR rheumatology SARS-COV-2 infection SARS-CoV-2 pneumonia scale secondary Secondary outcomes severe SARS the WHO therapeutic strategy thoracic medicine Treatment Trial trials usual care with COVID-19 [DOI] 10.1136/bmjopen-2021-050202 PMC 바로가기 [Article Type] Intensive Care
Low eGFR Is a Strong Predictor of Worse Outcome in Hospitalized COVID-19 PatientsArticle Published on 2021-11-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI Acute kidney injury Admission age AKI anti-platelet treatment blood glucose cardiovascular comorbidities cardiovascular risk chronic Chronic kidney disease CKD Clinical course Clinical deterioration co-morbidities component consecutive sample COVID-19 death died Elderly patient evaluate evaluated event glomerular filtration rate hazard ratio high risk Hospitalization hospitalized COVID-19 patients hospitalized patients ICU independent index Kidney disease LDH multivariate model occurred outcome Patient Prevent Primary outcome Probability reached reduced Respiratory failure Secondary outcomes serum creatinine significantly significantly higher SpO2 statistical analysis Strong Supportive treatment two group Univariate analysis whole sample [DOI] 10.3390/jcm10225224 PMC 바로가기 [Article Type] Article
Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized TrialRandomized Controlled Trial Published on 2021-11-092022-10-05 Journal: JAMA [Category] 임상, [키워드] 1:1 adjusted adjusted relative risk Adverse reactions Analysis benefit conducted COVID COVID-19 Critical daily dose Day days alive Dexamethasone dose Effect End Europe Follow-up fungal infections hospital identify India intravenous invasive Invasive mechanical ventilation IQR kidney life mean difference mechanical ventilation median median age Mortality multicenter number occurred outcome oxygen Patient patients with COVID-19 Primary outcome Randomized randomized clinical trial randomized patients Secondary outcomes Septic shock serious adverse reaction severe disease severe hypoxemia significant difference significantly more statistically Stratification Support therapy Trial variables women [DOI] 10.1001/jama.2021.18295 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical outcomes of intravenous immunoglobulin therapy in COVID-19 related acute respiratory distress syndrome: a retrospective cohort studyCOVID-19 관련 급성 호흡기 병원 증후군에서 정맥 내 면역 글로불린 요법의 임상 결과 : 후 향적 코호트 연구Research Published on 2021-11-082022-09-01 Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 진단, [키워드] 95% CI Acute kidney injury acute respiratory distress acute respiratory distress syndrome addition adjust AKI Analysis ARDS clinical Cohort conducted confounders coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Electronic health record Electronic health records General Hospital groups ICU ICU mortality ICUs Immunoglobulin immunoglobulin therapy immunomodulatory therapy incidence intensive care unit intensive care units Intravenous immunoglobulin Invasive mechanical ventilation IVIG mechanical ventilation mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mortality observation outcome Patient Primary outcome Propensity score propensity score matching randomized clinical trial receiving respiratory distress Respiratory distress syndrome Result Retrospective analysis retrospective cohort study routine care secondary Secondary outcomes significantly higher statistically significant difference study population supplementary material survival survival analysis syndrome systemic inflammation therapy two group two groups ventilator-free day Ventilator-free days was used with COVID-19 [DOI] 10.1186/s12890-021-01717-x PMC 바로가기 [Article Type] Research
Evaluation of the E-Mental Health Mindfulness-Based and Skills-Based “CoPE It” Intervention to Reduce Psychological Distress in Times of COVID-19: Results of a Bicentre Longitudinal StudyPsychiatry Published on 2021-11-042022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] age analyses Analysis analyzed Anxiety anxiety symptoms applied approach baseline caused clinical cognitive conducted COVID-19 COVID-19 pandemic Depression depressive symptom Depressive symptoms difference distress E-mental health effective Effectiveness Effects evaluated feasibility frequencies Gender Health Health care system Intervention Linear model longitudinal media mental health mental illness mindfulness mindfulness-based stress reduction offer Online intervention outcome overcome pandemic participant post-intervention Primary outcome Psychological distress reducing repeated Result SARS-CoV-2 pandemic Satisfaction secondary Secondary outcomes Self-efficacy significant decrease significant effect significant increase Study protocol Support Symptoms Tertiary therapy thought time Usability [DOI] 10.3389/fpsyt.2021.768132 PMC 바로가기 [Article Type] Psychiatry
Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical TrialCOVID-19가 있는 중환자의 장기 지원이 없는 날에 회복기 혈장의 효과: 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-022022-09-12 Journal: JAMA [Category] MERS, 임상, 진단, [키워드] 48 hour ABO-compatible convalescent plasma adjusted adverse event assigned benefit clinical convalescent plasma convalescent plasma group COVID-19 criterion Critically ill Critically ill patient cumulative Day days alive defined determine died domain Effect end point enrolled event Evidence futility greater hospital Ill Immunoglobulin IMPROVE In-hospital in-hospital mortality rate Inconclusive intensive care Intervention Invasive mechanical ventilation IQR less likelihood Logistic median median age Odds ratio Open-label organ organ support outcome Oxygenation participant Patient posterior probability primary analysis Primary outcome progression randomization Randomized receive REMAP-CAP reported secondary outcome Secondary outcomes Serious Adverse Events survival the median threshold Treatment treatment effect Trial venous thromboembolic Volume with COVID-19 women World Health Organization [DOI] 10.1001/jama.2021.18178 PMC 바로가기 [Article Type] Randomized Controlled Trial