Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19항 카디오리핀 IgG 자가항체는 심각한 COVID-19에서 순환하는 세포외 DNA와 연관됩니다Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] analyzed Anticoagulant association autoantibody circulating citrullinated histone citrullinated histones collected COVID-19 COVID-19 severity disease severity exacerbate extracellular DNA glycoprotein IgA IgG IgG and IgM IgM investigated Lupus lupus anticoagulant marker mild patients NET neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Patient patients with COVID-19 positive patient positive patients Prevalence prothrombin SARS-CoV-2 sera severe COVID-19 severe disease Severe patient severe patients severity the disease with COVID-19 [DOI] 10.1038/s41598-022-15969-y PMC 바로가기 [Article Type] Article
Immunogenicity of a vaccinia virus-based severe acute respiratory syndrome coronavirus 2 vaccine candidate백시니아 바이러스 기반 중증급성호흡기증후군 코로나바이러스 2 백신 후보의 면역원성Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody Response B.1.1.529 B.1.351 B.1.617.2 coronavirus COVID-19 COVID-19 pandemic develop Express immunogenicity inactivated mice mRNA Neutralizing activity recombinant spike proteins respiratory robust SARS-CoV-2 SARS-CoV-2 particles SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike proteins Support T-cell Response the SARS-CoV-2 Vaccine vaccine candidate vaccinia virus variants variants of concern vector Viral viral spike protein viral vectors VOCs was used Wuhan [DOI] 10.3389/fimmu.2022.911164 PMC 바로가기 [Article Type] Article
Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern구조 선택 RBM 면역원은 우려되는 SARS-CoV-2 변이체를 중화하는 다클론성 기억 반응을 일으킵니다.Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Affect Amino acid amino acid residue antibody Antibody Response B.1.351 B.1.617.2 booster C57BL/6 can be used conserved COVID-19 pandemic domain effort full-length full-length spike protein immunization immunogen immunogenic immunogens Immunoglobulin majority memory response mice neutralize Neutralizing Neutralizing antibodies neutralizing antibody Plasmid polyclonal Prevent Protein Proteins purified RBD RBM receptor-binding motif Recombinant spike protein resulting SARS-CoV-2 variant sera spike Spike protein Spike proteins the antibody response Transmission Vaccine variants variants of concern virus VoC VOCs vulnerability WA1 wildtype [DOI] 10.1371/journal.ppat.1010686 PMC 바로가기 [Article Type] Article
Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera중화 혈청에 대한 실험적 노출에 의한 SARS-CoV-2 주요 계통의 돌연변이 유도Article Published on 2022-07-212022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acquisition addition antibody characterisation escape mutation Evolution Evolution of SARS-CoV-2 human population immune evasion immune response Interaction Lineage Mutagenesis neutralisation neutralising neutralising antibody Neutralizing antibody response offer Perspective promoted required responsible SARS-CoV-2 sera species structural protein structural proteins target Viral viral adaptation viral variant [DOI] 10.1038/s41598-022-16533-4 PMC 바로가기 [Article Type] Article
Development of a Rapid Live SARS-CoV-2 Neutralization Assay Based on a qPCR ReadoutqPCR 판독을 기반으로 한 Rapid Live SARS-CoV-2 중화 분석의 개발Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody-mediated immunity antiviral activity calculate can be used characteristic controls correlation COVID-19 COVID-19 pandemic cross-neutralization demonstrated detect determine determined by development domain ELISA experiments faster generate gold gold standard Immunity Live virus natural infection neutralization Neutralization assay neutralization assays Neutralizing Neutralizing antibodies neutralizing antibody patient sera priority qPCR qRT-PCR Rapid Receptor-binding domain reduce reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 qRT-PCR Sensitivity and specificity sera significantly standard curve surrogate neutralization assay tested vaccination variants Vero E6 Vero E6 cell VERO E6 cells Viral Viral load Viral RNA virus virus isolate Virus neutralization [DOI] 10.1128/jcm.00376-22 PMC 바로가기 [Article Type] Article
A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients입원한 코로나19 환자의 면역 체계 반응 및 I형 인터페론 신호 전달 경로에 대한 종합 평가Article Published on 2022-07-162022-09-12 Journal: Cell Communication and Signaling : CCS [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract association autoantibody B lymphocyte CD4 CD8 conditions conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine decrease downstream dysregulation ELISA enrolled enzyme-linked immunosorbent evaluate evaluated expression expression level Factor flow cytometry Frequency healthy controls healthy individual hospitalized COVID-19 patient IFN-I IFN-I signaling IFN-α IFN-β IL-10 IL-17 IL-1β IL-6 illness Illness severity Immune cell immune system Immune-phenotype investigated IRF life-threatening material Mild Mild symptom NK cell NK cells Numerous Pathogenesis pathway Patient positive Protein protein levels Real-time PCR reduced Regulatory RNA SARS-CoV2 sera severity signaling molecule signaling molecules signaling pathway significant decrease Th17 TNF-α Treatment Treg Treg cell Vaccines virus [DOI] 10.1186/s12964-022-00903-6 PMC 바로가기 [Article Type] Article
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies이종 saRNA 프라임, DNA 이중 항원 부스트 SARS-CoV-2 백신 접종으로 강력한 세포 면역원성과 교차 변형 중화 항체 유도Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Adenovirus animal model animal models B.1.617.2 Beta boost CD4+ CD8+ T-cell combinations COVID-19 D614G mutation Delta distribution DNA dual dual antigen ENCODE enhanced expression followed by furin furin cleavage region Glutamine Heterologous highest homologous homologous or heterologous Humoral response humoral responses IgG immune response immune responses immunogenicity lipid carrier MHC class I MHC class I and II mice motif N antigen Neutralizing nucleic acid nucleocapsid omicron peptide peptides prefusion conformation prime proline prolines protease pseudovirus receiving regimen regimens Region response RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant self-amplifying RNA sequence sera serotype spike Stimulation strain Strains Support T-cell T-cell responses vaccination Vaccine Vaccines variant wild type Wuhan [DOI] 10.3389/fimmu.2022.910136 PMC 바로가기 [Article Type] Article
Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection AlonePre-Omicron 백신의 획기적인 감염은 단독 감염에 비해 SARS-CoV-2 Omicron BA.1에 대해 우수한 교차 중화를 유도합니다Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody antibody levels Antibody Response Antibody responses B.1 boost Breakthrough infection comparable convalescent convalescent sera convalescent serum correlated COVID-19 patient cross-neutralization cross-neutralizing antibodies cross-neutralizing antibody Delta disease elicited evade form Gamma had no higher affinity highlight Immunity individuals induce infecting Infection Live virus Mild moderate disease N-terminal domain neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity NTD nucleocapsid omicron Omicron BA.1 Patient patients with moderate Protein Proteins raise RBD Receptor-binding domain remained retained SARS-CoV-2 SARS-CoV-2 variants sera spike Spike protein Spike proteins strain Strains Superior the disease the RBD the receptor-binding domain the Spike the spike protein Transmissibility vaccination Vaccine Variability variant variants variants of concern variants of concern (VOCs) virus-induced antibodies VoC VOCs [DOI] 10.3390/ijms23147675 PMC 바로가기 [Article Type] Article
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage초기 단계에서 SARS-CoV-2에 감염된 Cynomolgus Macaque의 단백질체 및 대사체 특성 분석Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analyzed characterization COVID-19 COVID-19 infection cynomolgus macaque cynomolgus macaques Cytokines demonstrated dysregulated early infection early stage Efficacy effort feature Features immune immune response innate immune response lung tissue lung tissues lymphopenia macaque mechanism metabolomic profiling metabolomics moderate Moderate COVID-19 neutrophilia Pathogenesis pathogenic mechanism patients platelet activation proteomic proteomics SARS-CoV-2 SARS-COV-2 infection sera severe COVID-19 severe COVID-19 patients Stage Symptom the early stage. Therapeutics tissues Vaccine weakened [DOI] 10.3389/fimmu.2022.954121 PMC 바로가기 [Article Type] Article
Neutralizing Activity Against SARS-CoV-2 Delta and Omicron Variants Following a Third BNT162b2 Booster Dose According to Three Homologous or Heterologous COVID-19 Vaccination Schedules3개의 동종 또는 이종 COVID-19 백신 접종 일정에 따라 세 번째 BNT162b2 추가 접종 후 SARS-CoV-2 델타 및 오미크론 변이체에 대한 중화 활성Article Published on 2022-07-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against applied baseline characteristics BNT BNT162b2 booster dose ChAd ChAdOx1 coronavirus COVID-19 cross-reactive Delta delta variant dose evaluated followed by geometric mean geometric mean titer geometric mean titers groups Heterologous highest homologous or heterologous include investigated neutralization test Neutralizing neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody not significantly different omicron Omicron variant Omicron variants participant plaque-reduction neutralization test PRNT respiratory robust SARS-CoV-2 schedule sera severe acute respiratory syndrome Coronavirus slight increase Spread tested vaccination Vaccine vaccine dose Vaccine-induced immunity variant variants wild type [DOI] 10.3389/fcimb.2022.948014 PMC 바로가기 [Article Type] Article