Severe patient – Page 11 – Communicable Diseases Research

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

다중 플랫폼 omics 분석은 COVID-19 발병기전, 예후 및 약물 표적 발견을 위한 분자 서명을 보여줍니다

Article

Published on 2021-04-152022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 임상, 치료기술, 치료제,

RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trial

Research article

Published on 2021-04-142022-10-05
Journal: EClinicalMedicine [Category] 임상,

[키워드] 95% CI adaptive Adverse age anaphylaxis antibodies antibody assigned baseline blinded category Clinical improvement clinical scale clinical trial conducted dose double-blind Efficacy and safety Endpoint enrolled equine event finding Follow-up hazard ratio hospital hospital discharge Hospitalized hospitalized patient Immunotherapy interquartile range male Mild moderate disease Mortality multicenter neutralizing antibody Patient patients with COVID-19 patients with moderate phase 2/3 Placebo placebo-controlled placebo-controlled trial polyclonal polyclonal antibody primary endpoint Randomized Rate reached receive reported risk SARS-CoV-2 SARS-CoV-2 pneumonia severe COVID-19 Severe COVID-19 pneumonia severe disease Severe patient significantly higher statistically statistically significant difference study group subgroup analysis symptoms onset the placebo group the primary endpoint therapeutic time Treatment WHO
[DOI] 10.1016/j.eclinm.2021.100843 [Article Type] Research article

Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019

2019년 코로나바이러스 질병의 면역대사 재배선 및 면역병인에 대한 단일 세포 RNA 시퀀싱 분석

Immunology

Published on 2021-04-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] antibody secretion ATP13A3 ATP6V1B2 biological processe CD14 Cell cell population cell survival change contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Degradation differentiation elevated exacerbated expressed feature Glycolysis hyperinflammation Immune cell immune cells immune dysfunction Inflammation inhibit investigated involved KMT2E LDHA lead lysine mechanism memory B cell memory B cells metabolic changes mild patients mono monocyte Monocytes mononuclear cell mononuclear cells NSD1 Pathways Patient PBMCs Peripheral blood Peripheral blood mononuclear cells PGD PKM Plasma cell Plasma cells plasmablast plasmablasts progression promoted reduced RNA sequencing data SETD2 severe COVID-19 severe disease Severe patient severe patients signaling pathways Single-cell RNA sequencing survival TKT Transcription
[DOI] 10.3389/fimmu.2021.651656 PMC 바로가기 [Article Type] Immunology

Risk stratification scores for hospitalization duration and disease progression in moderate and severe patients with COVID-19

COVID-19 중등도 및 중증 환자의 입원 기간 및 질병 진행에 대한 위험 계층 점수

Observational Study

Published on 2021-04-142022-09-01
Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 임상, 진단,

[키워드] albumin assist C-reactive protein calibration clinical decision Clinical symptoms coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 patient creatinine Critical decision discrimination disease Disease progression evaluated Factor healthcare Healthcare provider healthcare providers high risk high risk patients hospital Hospitalization identifying Lactate lactate dehydrogenase Length of hospital stay less logistic regression model lymphocyte maximum body temperature median moderate neutrophil Neutrophil-to-lymphocyte ratio outbreak outcome outcomes Patient patients with moderate performed Platelet Platelet count poor prognosis predict Prognosis prognosis of patients prothrombin Prothrombin time recruited respiratory respiratory diseases Result retrospective cohort study risk Risk category risk score risk stratification Risk stratification score score severe COVID-19 Severe patient severe patients Stratification stratified supplementary material Support was used with COVID-19
[DOI] 10.1186/s12890-021-01487-6 PMC 바로가기 [Article Type] Observational Study

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

시분할 시스템 면역학은 치명적인 COVID-19와 관련된 후기 시점을 보여줍니다

Article

Published on 2021-04-012022-09-11
Journal: Cell [Category] Fulltext, MERS, 바이오마커, 유전자 메커니즘,

[키워드] Analysis Apoptosis CD16 CD56 CD8 cellular circulating CITE-seq clinical monitoring COVID-19 COVID-19 patients dendritic cells disease severity elevated Exhaustion exhibit fatal COVID-19 Fatty acid fatty acid metabolism gene expression signature heterogeneity Hospitalization immune Immune cell immune cells immune juncture immune response immunology Inflammation Inflammatory responses interleukin metabolism mixed-effect statistical modeling network analysis NK cell NK cells outcome outcomes plasmacytoid dendritic cell plasmacytoid dendritic cells Predictive Protein reveal sequence Severe patient severe patients Single Cell single cell multi-omics statistical Stress surface protein symptom onset T cell T cell activation T cell receptor therapeutic intervention time-resolved. trajectory Transcriptome Variation
[DOI] 10.1016/j.cell.2021.02.018 PMC 바로가기 [Article Type] Article

Folic acid as placebo in controlled clinical trials of hydroxychloroquine prophylaxis in COVID-19: Is it scientifically justifiable?

COVID-19에서 하이드록시클로로퀸 예방에 대한 통제된 임상 시험에서 위약으로서의 엽산: 과학적으로 정당화될 수 있습니까?

Article

Published on 2021-04-012022-08-31
Journal: Medical Hypotheses [Category] MERS, 임상, 치료제,

Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19

중등도 및 중증 코로나19 환자에서 클로로퀸 대비 하이드록시클로로퀸의 유효성 및 안전성 평가

Comment

Published on 2021-04-012022-09-11
Journal: Science China. Life sciences [Category] SARS, 치료제,

[키워드] Chloroquine Efficacy and safety Hydroxychloroquine moderate Severe patient with COVID-19
[DOI] 10.1007/s11427-020-1871-4 PMC 바로가기 [Article Type] Comment

Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe vs . common disease

Original Paper

Published on 2021-03-292022-11-01
Journal: Epidemiology and Infection [Category] COVID-19,

[키워드] accompanied Admission analysed changes in characteristic clinical Clinical characteristics common disease coronavirus disease Course COVID-19 COVID-19 disease severity COVID-19 patient cut-off value Cutoff diagnosed discharged FIVE generate hospitalisation increases in indicated Laboratory lymphocyte Moderate COVID-19 monocyte Neutrophil-to-lymphocyte ratio Neutrophils NLR parameter Patient patients PCT positive correlation procalcitonin relationship SARS-CoV-2 selected sensitivity severe group Severe patient severity severity of COVID-19 significant difference specificity statistically significant Symptoms treated White blood cells
[DOI] 10.1017/S0950268821000674 PMC 바로가기 [Article Type] Original Paper

An emergency system for monitoring pulse oximetry, peak expiratory flow, and body temperature of patients with COVID-19 at home: Development and preliminary application

집에서 COVID-19 환자의 맥박 산소 측정, 최대 호기량 및 체온 모니터링을 위한 비상 시스템: 개발 및 예비 적용

Research Article

Published on 2021-03-262022-09-12
Journal: PLoS ONE [Category] SARS, 진단,

[키워드] abnormality acute deterioration asymptomatic to mild automatically body temperature Cell change characterized contribute Control COVID-19 Desaturation described develop development disease evaluate event Evidence experimental results expiratory Expiratory flow help hospital hospital resource hospital resources include involved LabVIEW medical staff Mild disease minute oxygen oxygen saturation pathophysiology Patient patients patients with COVID-19 peak expiratory flow performed predicted presenting pulse oximetry Real-time monitoring recommendations reduced remote monitoring respond Severe patient the patient this system Transmission
[DOI] 10.1371/journal.pone.0247635 PMC 바로가기 [Article Type] Research Article

The severity and atypical presentations of COVID-19 infection in pediatrics

소아과에서 COVID-19 감염의 중증도 및 비전형적 표현

Case Reports

Published on 2021-03-252022-09-01
Journal: BMC Pediatrics [Category] SARS, 임상, 진단, 치료기술,

[키워드] 2019-nCoV acute pancreatitis affected age Atypical Boy Chain Reaction children conducted confirmed case Contact COVID-19 COVID-19 infection COVID-19 patients COVID-19 severity D-dimer Deep venous thrombosis emergence family members fatigue Fever group headache hypoxia infected with COVID-19 Inflammatory International manifestation Manifestations manifested mechanical ventilation median MIS-C MOST multivariate regression analysis nucleic acid Observational cohort study Pancreatitis polymerase chain polymerase chain reaction public health emergency real-time reverse transcriptase Result reverse transcriptase Severe case severe cases severe COVID-19 Severe patient severe patients severity severity of COVID-19 Shock significant difference significant differences significantly higher syndrome thrombosis Venous thrombosis WHO
[DOI] 10.1186/s12887-021-02614-2 PMC 바로가기 [Article Type] Case Reports