Assessment of proton-coupled conformational dynamics of SARS and MERS coronavirus papain-like proteases: Implication for designing broad-spectrum antiviral inhibitorsARTICLES Published on 2020-09-212022-10-30 Journal: The Journal of Chemical Physics [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral drug antiviral inhibitor assessment assist calculated catalytic caused computation conformational coronavirus CoV cysteine cysteine protease drug target Evidence flexible GPU Hypothesis inhibitor lack MERS coronavirus MERS-CoV Middle East modulate molecular Outbreaks pandemic Papain-like protease physiological plasticity PLPro Prevent protonation state residue respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Simulation starting point structure-based design Support supported viral life cycle [DOI] 10.1063/5.0020458 PMC 바로가기 [Article Type] ARTICLES
COVID-19 therapy and preventionReview Article Published on 2020-09-102022-11-01 Journal: Discoveries [Category] COVID-19, [키워드] activities antimicrobial agent caused Chloroquine collected Combination comparison coronavirus COVID-19 Dexamethasone diagnosed disease effective Efficacy effort epidemiological Evidence Evolution Favipiravir Government Hydroxychloroquine immunomodulators information interferon Mask measure New coronavirus other coronaviruses outbreak Outbreaks pandemic Perspective Pneumonia provide provided question raised Remdesivir Respirator SARS-CoV-2 SARS-CoV-2 remdesivir similarity starting point Support the mean therapeutic Therapies therapy Tocilizumab Transmissibility Vaccine Vaccines virus [DOI] 10.15190/d.2020.10 PMC 바로가기 [Article Type] Review Article
Nursing Surge Capacity Strategies for Management of Critically Ill Adults with COVID-19Review Published on 2020-09-082022-10-31 Journal: Nursing Reports [Category] COVID-19, [키워드] affecting appraisal build Capacity Care CINAHL clinical Complication conducted coronavirus Coronavirus 2019 COVID-19 COVID-19 pandemic COVID-19 patients Critical care critically ill patients database develop Evidence Healthcare professional ICU ICU surge capacity Ill IMPROVE intensive care Joanna Briggs Institute knowledge literature Multiple Nurse Nursing nursing surge capacity and strategies pandemic Patient question recommendation Relevance Research resource Spread starting point Strategy Support supported with COVID-19 [DOI] 10.3390/nursrep10010004 PMC 바로가기 [Article Type] Review
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performanceResearch Article Published on 2020-09-022022-10-31 Journal: eLife [Category] Coronavirus, [키워드] allele caused CD163 coronavirus Coronavirus infections CRISPR/Cas9 cross diarrhea Diseases disorder effective Epidemics Evidence exhibited experiment gastroenteritis Genotype healthy help Host host’s cell humans illnesses in vivo infect infect cells Infection infection mechanism knowledge no difference offer pathogenic virus PDCoV pig Porcine deltacoronavirus Premature Prevent produced producing Protein PRRSV receptor protein receptors reduce remained reproductive respiratory virus Safe sick starting point Stillbirth susceptibility syndrome TGEV traits virus viruses were infected wild-type [DOI] 10.7554/eLife.57132 PMC 바로가기 [Article Type] Research Article
The impact of the COVID-19 pandemic response on other health researchPolicy & Practice Published on 2020-09-012022-10-27 Journal: Bulletin of the World Health Organization [Category] COVID-19, [키워드] affected approach caused complex coronavirus disease COVID-19 COVID-19 pandemic COVID-19 research data integrity Effect flexible Government Guidance Health highlight International introduced lockdown Major measure pandemic Research researcher risk significantly Sponsor starting point study participant subject while [DOI] 10.2471/BLT.20.257485 PMC 바로가기 [Article Type] Policy & Practice
The impact of the COVID-19 pandemic response on other health researchPolicy & Practice Published on 2020-09-012022-10-27 Journal: Bulletin of the World Health Organization [Category] Coronavirus, COVID-19, SARS, [키워드] affected approach caused complex coronavirus disease COVID-19 COVID-19 pandemic COVID-19 research data integrity Effect flexible Government Guidance Health highlight International introduced lockdown Major measure pandemic Research researcher risk significantly Sponsor starting point study participant subject while [DOI] 10.2471/BLT.20.257485 PMC 바로가기 [Article Type] Policy & Practice
A Dental Response to the COVID-19 Pandemic—Safer Aerosol-Free Emergent (SAFER) DentistryMedicine Published on 2020-08-122022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] adaptation administration aerosol-generating procedure Aerosols agency airborne transmission of diseases approach association Care conditions COVID-19 COVID-19 pandemic dental Dental care Dental service dentistry disease transmission emergency dental service equipment generate impacted implementation include infection control infection risk infectious dental aerosols Intervention pandemic pandemic preparedness and response Pathogens pathway Patient Potential public health respond response risk significantly Spread starting point Treatment [DOI] 10.3389/fmed.2020.00520 PMC 바로가기 [Article Type] Medicine
The Impact of COVID-19 Crisis upon the Consumer Buying Behavior of Fresh Vegetables Directly from Local Producers. Case Study: The Quarantined Area of Suceava County, RomaniaArticle Published on 2020-07-292022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis applied Area Behavior change conducted consumer COVID-19 COVID-19 crisis crisis Fresh Impact Intention Interpretation Local local producers quarantine questionnaire Research Romania short food supply chains Sociodemographic factor starting point Suceava Suceava County triggered vegetable [DOI] 10.3390/ijerph17155485 PMC 바로가기 [Article Type] Article
Students under lockdown: Comparisons of students’ social networks and mental health before and during the COVID-19 crisis in SwitzerlandResearch Article Published on 2020-07-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] Analysis Anxiety Cohort collected comparison courses COVID-19 COVID-19 crisis COVID-19 pandemic Depression depressive symptom dimension Effect emotional Health higher risk identify Interaction Isolation lack loneliness Longitudinal data measure mental health offer physical Psychological researcher social contact social isolation starting point Stress Stressor stressors student Support Switzerland Trajectories trajectory [DOI] 10.1371/journal.pone.0236337 PMC 바로가기 [Article Type] Research Article
From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular MimicryArticle Published on 2020-07-162022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] analyzed autoantibody Autoimmune Autoimmunity composed coronavirus 2 COVID-19 cross-reactivity disorders distress epitope human protein IEDB Infection mimicry molecular mimicry multiple organ failure mutated pathologic peptide peptide sharing Perspective Protein target protein targets proteome respiratory response SARS-CoV-2 SARS-CoV-2 epitopes SARS-COV-2 infection SARS-CoV-2 pandemic sequence sera starting point Surveillance [DOI] 10.3390/antib9030033 PMC 바로가기 [Article Type] Article