Evolutionary and Antigenic Profiling of the Tendentious D614G Mutation of SARS-CoV-2 in Gujarat, IndiaGenetics Published on 2021-11-112022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] affected analyzed antigenic antigenic propensity antigenicity caused clades country D614G D614G variant deaths disease Ebola effective Frequency Genome genome sequence GISAID Gujarat India Infection L452R Lakh MERS Mutation mutations NCBI P681R Pandemics peptide phylogenetic distribution Phylogeny Profiling reported Repository residue SARS-CoV-2 spike glycoprotein Spike protein submitted suffered the spike protein variant viral genome virus [DOI] 10.3389/fgene.2021.764927 PMC 바로가기 [Article Type] Genetics
Electrical impedance tomography in pediatric patients with COVID-19, the first reportsCovid-19를 가진 소아 환자의 전기 임피던스 단층 촬영, 첫 번째 보고서Observational Study Published on 2021-11-082022-09-01 Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] Chest Chest radiograph clinical study Computed tomography COVID-19 COVID-19 infection COVID-19 patients distribution electrical impedance Electrical impedance tomography evaluate hospital intensive care intensive care unit ionizing radiation Lung diseases mitigate MONITOR morphological change morphological changes no sedation noninvasive objective Patient patients pediatric pediatric cohort Pediatric intensive care Pediatric patient Pediatric patients positive Radiation radiological real time repeated Result Sedation submitted tested Thoracic tomography Ventilation ventilatory was used with COVID-19 [DOI] 10.1186/s12890-021-01716-y PMC 바로가기 [Article Type] Observational Study
Cardiogenic shock with highly complicated course after influenza A virus infection treated with vva-ECMO and Impella CP (ECMELLA): a case reportCase Report Published on 2021-11-082022-10-27 Journal: BMC Public Health [Category] Coronavirus, MERS, SARS, [키워드] Admission approach Artery bleeding Cardiogenic shock Cardiomyopathy Case report cause Combination Complete Course CT-scan discharged ECMO exceptional exclusion extracorporeal membrane oxygenation febrile female healthy Impella Infection Influenza influenza A virus initial invasive ventilation Local LVEF Mechanical circulatory support myocarditis neurological occurred Patient positive Prognosis recovery rehabilitation respiratory acidosis rising SARS-CoV-2 Shock submitted Support temperature treated Vascular ventricular was performed was tested while younger patient [DOI] 10.1186/s12872-021-02346-2 PMC 바로가기 [Article Type] Case Report
926. COVID-19 Infections After SARS-CoV-2 Vaccination in Solid Organ Transplant RecipientsPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] administration Bank board Breakthrough infection Case report Characteristics clinical Clinical characteristics Clinical data collected consultant correlation COVID-19 COVID-19 disease severity COVID-19 infection COVID-19 vaccine Critical Critical disease demographics demonstrated Descriptive analysis died disease severity Effectiveness employee Factor foundation Hospitalization Humoral response identify immunocompromised individuals Impact incidence individual Infection IQR Lilly median member MOST network no difference occurred outcome outcomes Patient performed Pfizer recipient reduced required Result risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine Solid solid organ submitted Symptom table Transplant vaccination Vaccine vaccine administration with COVID-19 [DOI] 10.1093/ofid/ofab466.1121 PMC 바로가기 [Article Type] Poster Abstracts
The COVID-19 pandemic in the WHO African region: the first year (February 2020 to February 2021)WHO 아프리카 지역의 COVID-19 범유행: 원년(2020년 2월 ~ 2021년 2월)Short Paper Published on 2021-11-042022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 변종, [키워드] accounted affected African African region case fatality ratio CFR changed comorbid condition comorbid conditions Comorbidities contributed coronavirus coronavirus disease country COVID-19 COVID-19 pandemic COVID-19 vaccine Critical death diabete diabetes dose early stage Effectiveness epidemiological fatigue Health Organization health system health systems HIV Human immunodeficiency virus hypertension immunodeficiency virus IMPROVE Infection laboratory-confirmed lockdown lockdowns measure occurred pandemic Pandemic response Pandemics Patient proportion public health public health and social measures recorded reported second wave Spread submitted subsequent the WHO trajectory variants of concern VoC World Health Organization [DOI] 10.1017/S0950268821002429 PMC 바로가기 [Article Type] Short Paper
1088. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration airway Ambrose ambulatory patient Andrew association being binding kinetics binding site calculated CDC Complete Concentration coronavirus Course COVID-19 criteria Developed dissociation rate distribution Donald dose employee epithelial lining evaluated expressed Extended figure human IgG1 in vitro Inc Inc. indicated initial viral load intramuscularly log maintain material median Mild Model Moderate COVID-19 Molar monoclonal antibody neutralization Other pandemic patients Pharmacology phase Post-infection profile rate constant Receptor occupancy regimen regimens representing Result SARS-CoV-2 SARS-CoV-2 viral SARS-like CoV Selection Spike protein submitted Support System Therapeutics threshold Treatment Trial Van viral clearance viral growth Viral load virion Walker Wart was used were used [DOI] 10.1093/ofid/ofab466.1282 PMC 바로가기 [Article Type] Poster Abstracts
1089. Use of a Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Prevention of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration Adults Ambrose anticipated being Bioavailability CDC center Concentration Control coronavirus COVID-19 COVID-19 vaccine Developed distribution dose employee evaluated exceeded Extended figure geometric human IgG1 in vitro Inc Inc. include inhibitory concentration inter-individual intramuscularly linear material median Model monoclonal antibody Neonatal neutralization neutralization potency neutralization titer neutralizing antibody non-human primate Other pandemic Pharmacology phase plaque reduction neutralization predicted prevention prevention of COVID-19 profile recipients regimen regression equation reported representing required Result SARS-CoV-2 SARS-COV-2 infection SARS-like CoV Selection serum shown submitted Support System Therapeutics threshold transfer Trial Van Variation virus Walker Wart were used [DOI] 10.1093/ofid/ofab466.1283 PMC 바로가기 [Article Type] Poster Abstracts
Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factorsObservational Study Published on 2021-11-012022-10-05 Journal: Respiratory medicine [Category] 임상, [키워드] admitted to ICU Aspergillus C. albican Candida candidiasis clinical outcomes Co-infection COVID-19 COVID-19 patient determine develop diagnosis of COVID-19 Escalation Fungal infection ICU IFI Infection interferon isolate mortality rate Patient patients Pneumonia positive presenting Prevalence radiological involvement reported Result risk risk factor SARS-COV-2 infection severe pneumonia submitted suggested systemic systemic Candidiasis systemic steroids tested Tocilizumab Viral pneumonia [DOI] 10.1016/j.rmed.2021.106619 PMC 바로가기 [Article Type] Observational Study
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 20212021 년 2 월 코네티컷의 개에있는 심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2)Brief Report Published on 2021-10-232022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conducted Connecticut coronavirus coronavirus 2 COVID-19 D614G diagnostic died dog dominant ENhance Epidemiology Genetic Genome sequencing HCoV Human identify In situ hybridization Laboratory Lineage multiple organ multiple organs Mutation negative Nsp12 P323L Phylogenetic analysis positive postmortem examination public health real time-PCR respiratory reverse transcription RNA RNAscope RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus submitted substitutions sudden death The United States United States Viral Viral RNA virus Winter zoonotic [DOI] 10.3390/v13112141 PMC 바로가기 [Article Type] Brief Report
Incidence of SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential Workers During a Prevaccination COVID-19 Surge in ArizonaResearch Published on 2021-10-222022-10-30 Journal: JAMA Health Forum [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted age Analysis Care Cohort cohort study Community comparable confounder confounding factors Contact COVID-19 COVID-19 pandemic COVID-19 vaccine defined elevated Enrollment Essential essential worker Essential workers exposure finding first positive generate greater Guidance Health Health status Hispanic Importance incidence incidence rate individuals Infection infection risk measure multivariable model nasal swab negative objective operator Other participant performed Point polymerase chain prevaccination prospective cohort study PROTECT public health real-time reverse transcriptase Relevance remained Research Responder responders Result risk SARS-CoV-2 SARS-COV-2 infection seronegative setting significantly higher Sociodemographic characteristics specimen study cohort submitted understanding was used while white worker [DOI] 10.1001/jamahealthforum.2021.3318 PMC 바로가기 [Article Type] Research