A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides비정규 RNA 분해 경로는 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이를 억제합니다Research Article Published on 2017-03-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation animal hosts Antifungal treatment Community component Compound conditions Degradation described determined by Dicer drug target drug-resistant effective Efficacy emerging disease ENhance environmental condition environmental conditions expression FK506 fungal Fungal infection fungal pathogen fungal pathogens fungi generate genetic analysis growth Helicase Host host-pathogen interaction host-pathogen interactions Human include inhibitory inhibitory effect involved isolate isolates lack mechanism molecular mechanism mRNA degradation Mucor Mucorale Mucorales Mucormycosis Mutation non-canonical RNA pathogen Pathogens pathway performed phenotype phenotypic plasticity prevented previous study Prognosis Protein provided RdRP recent Regulation represse Research RNAi RNAi pathway strain Strains stress conditions suppresse Target genes underlie [DOI] 10.1371/journal.pgen.1006686 PMC 바로가기 [Article Type] Research Article
Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγResearch Paper: Immunology Published on 2017-02-072022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] abrogated Affect association bind cause Cell Corona Cytokines demonstrated DPP4 Effect effective expression glycoprotein IL-10 IL-6 immune response Immunity Immunology and Microbiology Section immunosuppressive cytokine immunosuppressive effect infect infecting Infection inhibition inhibitor IRAK-M Lentiviral particle LPS-activated lung epithelial cell Macrophage Macrophage response macrophages MERS CoV MERS-CoV middle Middle East Monocytes pathogenicity Peripheral blood PPARγ pseudotyped receptor recognize reduced respiratory respiratory tract S glycoprotein siRNA spike Support suppresse syndrome THP-1 TLR signaling transcriptional repressor transmitted virus Virus spike [DOI] 10.18632/oncotarget.14754 PMC 바로가기 [Article Type] Research Paper: Immunology
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3Original Article Published on 2016-04-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Activation antiviral response association C-terminal C-terminal domain characterized chimeric claimed conserved contribute evade ex vivo models expression highly pathogenic Host IFN induce infected patient Infection inhibitory effect innate antiviral response interferon IRF3 IRF3 activation M protein mechanism MERS coronavirus MERS-CoV Middle East mutants N-terminal nuclear Pathogenesis Phosphorylation Protein reduced Regulatory respiratory syndrome coronavirus resulting RIG-I-like receptors SARS-CoV Saudi Arabia Sendai virus suppress suppresse suppressed TRAF3 transmembrane domain Type I IFN type I interferon type I interferons [DOI] 10.1038/emi.2016.33 PMC 바로가기 [Article Type] Original Article
Arabidopsis thaliana RESISTANCE TO FUSARIUM OXYSPORUM 2 Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root InfectionArabidopsis thaliana FUSARIUM OXYSPORUM 2에 대한 내성은 뿌리 감염에 대한 감수성과 내성에 티로신-황산염 신호 전달을 의미합니다Research Article Published on 2013-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Affect Arabidopsis thaliana Diversity downregulate effector explain expression Extracellular Fusarium Gene Genes host immunity induce Infection inhibit lethal leucine loci locus mutant mutants negative feedback pathogen-specific peptide plant promote Protein provide QTLs Quantitative receptor Regulation related relative susceptibility replaced resistance root Signaling Support suppresse susceptibility traits transgenic tyrosine Vascular while [DOI] 10.1371/journal.pgen.1003525 PMC 바로가기 [Article Type] Research Article
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article
CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral InfectionResearch Article Published on 2012-05-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence Activation administration anti-viral response Author blocker Cancer CD200 clearance clinical trial Control dependent on determine determined different disease disease symptom ENhance Factor female female patient females Host humans Hypothesis IFN immune immune inhibitory immune response immune system immunological impair implication IMPROVE in vitro in vivo Infection influenza A virus Influenza virus inhibit inhibitory inhibitory signal lack Ligand lung MHV mice microbial infection mouse hepatitis neutrophil observé outcome overactive pathogen pathology pathway predict Prevent provided receptor receptors Release reported response Sex Sex difference Signaling supported suppresse therapeutic targeting therapeutic use threshold TLR7 Treatment Type I IFN type I interferon viral clearance viral infection virus virus infection [DOI] 10.1371/journal.ppat.1002710 PMC 바로가기 [Article Type] Research Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article
Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirusResearch Published on 2006-03-292022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate acute respiratory syndrome Antiviral antiviral gene Caco-2 Cell cell line cell lines cell types cells chemokine chemokine gene Colon Course cytokine cytokine profile cytokine response determine disease dissemination embryonic kidney Gene Expression Host IFN-α IFN-β IFN-λ1 IL-6 IL-8 Immune cell infect Infected infiltration inhibition investigated IP-10 lung marker non-immune RANTES Result SARS Coronavirus SARS patient SARS-CoV suppresse the interferon tissue Transcription triggered virus [DOI] 10.1186/1743-422X-3-17 PMC 바로가기 [Article Type] Research