Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adultsCOVID-19에 감염된 어린이의 면역 반응은 감염된 성인보다 낮은 수준의 T 세포 활성화가 특징입니다Article Published on 2020-09-012022-09-12 Journal: European Journal of Immunology [Category] SARS, 진단, [키워드] activated activated T cell addition Adults CCL5/RANTES CD4 CD8 Cell characterized children children with COVID-19 COVID-19 CXCL9 CXCL9/MIG expressing expression feature IL-12 IL-1β immune response immunological SARS-CoV-2 SARS-CoV2 T-cell activation T-cell activation. Th1 with COVID-19 [DOI] 10.1002/eji.202048724 PMC 바로가기 [Article Type] Article
Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress SyndromeOriginal Article Published on 2020-08-222022-10-30 Journal: Journal of Clinical Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation alteration antibody-secreting cells Antiviral Apoptosis approach Blood CD57 cell cytotoxicity clinical Cohort complementary conducted COVID-19 Cytokines effector T cell endothelial Europe Evolution exhibited expressing French hyperinflammatory status immune dysfunction immune response immunomodulator increase in longitudinal analysis lung trafficking marker Monocytes multiorgan failure nasopharyngeal NK-cell outcome pathophysiological Patient patients with COVID-19 populations pro-inflammatory cytokine storm Registered respiratory SARS-CoV-2 serum supplementary material T cell T cells Th1 Th2 Treatment viral replication [DOI] 10.1007/s10875-020-00839-x PMC 바로가기 [Article Type] Original Article
Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung InjuryImmunology Published on 2020-08-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activity addition alleviate animal models antiviral activity cause clinical study coronavirus disease Coronavirus disease 2019 COVID-19 cytokine production Cytokine storm disease drugs Effect excessive inflammation fatality immune immunomodulatory activity Infection inhibit inhibit SARS-CoV-2 inhibiting Lung injury Macrophage metformin Mortality Multiple organ damage NETs Neutrophil extracellular trap pandemic pathogenesis of SARS-CoV-2 pathogenic patients with COVID-19 Potential Proinflammatory cytokine proteomic study reduce retrospective risk SARS-CoV-2 SARS-COV-2 infection severe lung injury severity Side effects syndrome T2D Th1 Th17 cells treat treating Treatment type 2 diabete with COVID-19 [DOI] 10.3389/fimmu.2020.02056 PMC 바로가기 [Article Type] Immunology
Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?Opinion/Hypothesis Published on 2020-05-132022-10-30 Journal: mSphere [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome agent Anti-inflammatory antiviral agent Can CCL2 chemokines clinical trial coronavirus COVID-19 COVID-19 symptom CXCL10 disease symptom DNA effective Effectiveness evaluate IL-1 IL-6 immune response immunomodulatory activity Immunomodulatory agent Immunomodulatory agents immunopathological induce Inflammatory Inflammatory cytokine inhibit Interferon alpha low-dose phytocannabinoids Protein respiratory infection SARS Coronavirus SARS-CoV-2 severity Th1 Th1 cytokine Th2 thimerosal Vaccine variety [DOI] 10.1128/mSphere.00288-20 PMC 바로가기 [Article Type] Opinion/Hypothesis
Cardiovascular Impairment in COVID-19: Learning From Current Options for Cardiovascular Anti-Inflammatory TherapyCardiovascular Medicine Published on 2020-04-302022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] addition Algorithm Anti-inflammatory therapy cardiovascular cardiovascular anti-inflammatory therapy cardiovascular disease cardiovascular diseases cardiovascular impairment caused China clinical trial clinical trials Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm Direct Drug screening Efficacy and safety ENhance feature global pandemic high risk IL-1β IL-6 impairment in vitro Inflammation Inflammatory learning management mechanism mitigate MODS multiple organ dysfunction occurred option outcomes pathway positive preclinical study proceed profiles Prognosis Protective reduce SARS-CoV-2 Severe case syndrome Th1 Th2 response TNF-α translation Treatment treatments of COVID-19 viral infection [DOI] 10.3389/fcvm.2020.00078 PMC 바로가기 [Article Type] Cardiovascular Medicine
Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells살모넬라균은 T 세포가 부족한 육아종에서 활성화된 대식세포에 지속하지만, 주변의 CXCR3 리간드에 위치한 Th1 세포에 의해 억제된다.Article Published on 2018-12-182024-08-22 Journal: Immunity [Category] 살모넬라증, [키워드] CXCR3 granuloma phagosomal pathogen. Th1
Schistosome Eggs Impair Protective Th1/Th17 Immune Responses Against Salmonella Infection주혈흡충 알이 살모넬라 감염에 대한 보호적인 Th1/Th17 면역 반응을 저해한다.Original Research Published on 2018-11-142024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] Co-infection immunoregulation IPSE/alpha-1 Salmonella Typhimurium Schistosoma mansoni Th1 Th17 [DOI] 10.3389/fimmu.2018.02614 PMC 바로가기 [Article Type] Original Research
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle AntigenArticle Published on 2018-10-162023-06-24 Journal: Immunity [Category] 신종인플루엔자, [키워드] Antigen presentation antigen-presenting cell APC B cells CD4(+) T cells MYD88 nanoparticle Tfh Th1 TLR Tolerance Toll-like receptor Vaccine Virus-like particle VLP [DOI] 10.1016/j.immuni.2018.08.012
Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seqResearch Article Published on 2018-08-072022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated addition Allograft Alter Analysis APN Apoptosis Autoimmune disorders B cell Cell change characterization collected cytotoxicity DC-SIGN death deregulated disease Diseases dissemination down-regulated enrichment analysis Fever fold healthy Host immune complex indicated Interaction involved KEGG L-SIGN Laboratory less lymphopenia Macrophage mature macrophages MHC I mRNA mRNA expression NK cell other coronavirus pathogen pathway peritoneal macrophage populations receptor rejection RNA expression RNA-Seq serotype Signaling significantly Th1 Th2 transcript upregulated virus were infected [DOI] 10.1186/s13567-018-0578-y PMC 바로가기 [Article Type] Research Article
Model of Persistent Salmonella Infection: Salmonella enterica Serovar Pullorum Modulates the Immune Response of the Chicken from a Th17-Type Response towards a Th2-Type Response지속적인 살모넬라 감염 모델: 살모넬라 엔테리카 세로바 풀로룸이 닭의 면역 반응을 Th17 유형 반응에서 Th2 유형 반응으로 조절한다.Article Published on 2018-07-232024-08-22 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] Adaptive immunity CD4+ T cells chickens Macrophage macrophages persistent infection Salmonella Salmonella enterica serovar Enteritidis Salmonella enterica serovar Pullorum T cell immunity Th1 Th17 Th2