therapeutic targets
[용어속성] Term
High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
Article
[키워드] acute phase response
Analysis
association
body mass index
C-reactive protein
Comorbidity
Concentration
concentrations
correlated
COVID-19
COVID-19 pathogenesis
COVID-19 patient
COVID-19 patients
Cytokines
dysregulated immune response
enrolled
Fatty acid
feature
form
HDL
High-density lipoprotein cholesterol
hospitalized patient
Immunopathogenesis
Infection
initial
intensive care
lipoprotein metabolism
metabolic disorder
MOST
NEFA
Non-COVID-19
obese patients
Organ failure
outcome
Pathogenesis
patients hospitalized
plasma
plasma concentration
Pneumonia
Polyunsaturated
PUFA
required
respiratory severity
Sepsis
Severe COVID-19 pneumonia
severe pneumonia
SOFA
therapeutic targets
to define
unique
Ventilator-free days
were assessed
with COVID-19
[DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article
The Molecular Basis of COVID-19 Pathogenesis, Conventional and Nanomedicine Therapy
COVID-19 병인의 분자적 기초, 기존 및 나노의학 요법
Review
[키워드] accompanied
activate
Activation
acute respiratory distress
acute respiratory distress syndrome
acute respiratory syndrome
acute respiratory syndrome coronavirus
ADP-ribose
angiotensin
Angiotensin II
Apoptosis
Basis
blocker
blockers
Cell
cell death
clinical manifestation
clinical manifestations
Conventional
Coronaviridae family
coronavirus
coronavirus disease
Coronavirus disease-19
COVID-19
COVID-19 pathogenesis
cytokine
Cytokine storm
develop
DNA damage
Endothelial dysfunction
explained
Health Organization
highly pathogenic
humans
infect
inhibiting
investigated
involved
iron
iron oxides
losartan
macrodomain
mechanism
mefenamic acid
MERS-CoV
Middle East
Middle East respiratory syndrome Coronavirus
molecular mechanisms
morbidity
morbidity and mortality
nanomedicine
Necrosis
non-structural protein
outbreak
oxidative burst
oxidative stress
pandemic
PARG
PARP
pathogenic virus
Potential
potential therapeutic targets
protein 3
quantum dots
RAS
RAS pathway
receptor
receptor potential
Renin
renin-angiotensin system
respiratory
respiratory distress
Respiratory distress syndrome
respiratory syndrome coronavirus
SARS-CoV
SARS-CoV-2
severe acute respiratory syndrome Coronavirus
signaling pathway
Spread
syndrome
tannins
the Coronaviridae
therapeutic agent
therapeutic agents
therapeutic targets
thought
trehalose
TRPM2
Viral
virus
virus entry
Vitamin D3
World Health Organization
[DOI] 10.3390/ijms22115438 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms22115438 PMC 바로가기 [Article Type] Review
RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field
Review
[키워드] αvβ3
αvβ6
accumulated
Angiogenesis
approach
approaches
binding
Cancer
cancer progression
Cell
cells
Clinical studies
clinical trials
compounds
diagnostic
disease
dose
elevated
Exosomes
expression
fibrosis
field
function
functions
high accuracy
integrin
integrin targeted therapy
Integrins
investigated
knowledge
Ligand
ligands
Metastasis
molecular
molecular imaging
motif
non-cancerous
novel
nuclear
optical
other diseases
patient selection
pharmacological
progression
receptors
respiratory
RGD-binding integrins
SARS-CoV-2
SARS-COV-2 infection
selective
Sepsis
Signal transduction
simple
subtype
Subtypes
synthetic
synthetic integrin ligands
target
therapeutic target
therapeutic targets
therapy
translation
translational
Treatment protocol
treatment strategy
Trial
vascular normalization therapy
viral infections
[DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review
Genetic variability in COVID-19-related genes in the Brazilian population
Article
[키워드] 1000 Genomes Project
1KGP
ABO
ACE2
ACE2 gene
Affect
allele frequency
Analysis
analyzed
angiotensin-converting enzyme 2
Brazil
Brazilian
Brazilians
candidate gene
CCR9
Clinical prognosis
contribute
country
COVID-19
COVID-19 case
COVID-19 infection
COVID-19 patients
COVID-19 severity
CTSL
CXCR6
database
disease
DQB1
DRB1
examined
Exome
exomes
explain
FYCO1
gene sequence
genetic background
genetic study
genetic variability
Genetic variation
Genome
gnomAD
help
highest
HLA allele
Host
host cells
human lung cells
identify
IL6
Immunity
implicated
individual
individual level
infect
Infection
infection with SARS-CoV-2
Influenza virus
information
International
investigated
life-threatening
loci
LZTFL1
nonsynonymous
Other
Patient
Phase 3
Pneumonia
Population
predicted
previous study
Protein
Rare variants
rate of infection
recent
receptor
recorded
reported
risk
SARS-CoV-2
SARS-COV-2 infection
Seven
shown
SLC6A20
suggested
susceptibility
therapeutic targets
TMPRSS2
transmembrane serine protease
type I interferon
unique
university
Variability
variant
Variation
viral infection
XCR1
[DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article
Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase
클래스 III 포스포이노시티드 3-키나아제를 표적으로 하여 생체 외 인간 폐 조직에서 SARS-CoV-2 감염 억제
Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
addition
Antiviral effect
approved
ATG14
autophagolysosome
autophagy
Betacoronavirus
canonical
caused
cellular
class III PI3-K
clinically
complex
component
coronavirus
coronavirus disease
COVID-19
COVID-19 treatment
Ex vivo
ex vivo human lung tissues.
examined
Factor
HCQ
Host
human lung
human lung tissue
Immunosuppression
include
Infection
inhibit
inhibited
inhibiting
inhibitor
involved
kinase
Kinase inhibitor
lysosomal
novel Betacoronavirus
pandemic
pathway
Prevent
Previous studies
previous study
SARS-CoV-2
SARS-COV-2 infection
small molecule
small molecule inhibitor
Small molecule inhibitors
Small molecules
suggested
suppresse
suppressed
suppression
tested
therapeutic
therapeutic target
therapeutic targets
tissues
Transmissibility
Treatment
Ulk1
Vps34
[DOI] 10.1002/jmv.26583 PMC 바로가기 [Article Type] Article
[DOI] 10.1002/jmv.26583 PMC 바로가기 [Article Type] Article
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
실행 가능한 약물 가능 게놈 전체 멘델식 무작위화, COVID-19의 용도 변경 기회 식별
Article
Published on
Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제,
Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제,
[키워드] ACE2
approach
approved drug
approved drugs
association
Colocalization
conducted
controls
COVID-19
COVID-19 hospitalization
drug
Drug development
drugs targeting
Evidence
expression
genetic instrument
genetic instruments
Hospitalization
identify
IFNAR2
IL10RB
initiative
loci
management
mendelian randomization
Mendelian randomization analyses
Million Veteran Program
Pathway enrichment analysis
patients hospitalized
Protein
proteomic
provide
Quantitative
suggested
therapeutic target
therapeutic targets
Therapeutics
transcriptomic
Trial
with COVID-19
[DOI] 10.1038/s41591-021-01310-z PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41591-021-01310-z PMC 바로가기 [Article Type] Article
Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019
코로나바이러스 질병 2019에서 관련 경로 및 치료 약물의 스크리닝을 위한 통합 생물정보학 분석
Article
[키워드] 2019-nCoV
2019-nCoV coronavirus
acute respiratory syndrome
acute respiratory syndrome coronavirus
addition
Analysis
antiviral drug
Antiviral effect
antiviral effects
approved
assist
bioinformatics
Bioinformatics analysis
caused
Clinical research
Clinical treatment
clinically
conducted
contribute
coronavirus
Coronavirus infection
COVID-19
COVID-2019
database
disease
drug
Effects
EGCG
Epigallocatechin-3-gallate
expression
functional enrichment
Functional enrichment analysis
Genes
hub genes
human coronavirus
human protein
human proteins
ingredient
inhibit
inhibitor
inhibitors
Integrated analysis
Interaction
involved
mechanism
MERS
MERS-CoV
N protein
network analysis
Novel coronavirus
PKA
Previous studies
progression
Protein
reduce
Research
resveratrol
SARS-CoV-2
SARS-COV-2 infection
screened
Screening
selected
significant pathways
significantly
Stage
targets
therapeutic targets
trans
trans-resveratrol
transcriptional regulation
Treatment
Vaccine
virus
[DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article
Generation of recombinant hyperimmune globulins from diverse B-cell repertoires
Article
[키워드] antibodies
antibody
antibody repertoire
Antibody therapeutics
Antibody-dependent enhancement
approach
B-cell
convalescent
deficiency
demonstrated
disease
Efficacy
generate
Generation
human donors
hyperimmune
immune
immunized mice
Intravenous immunoglobulin
limitation
lung
mammalian
mice
molecular
Neutralizing activity
pathogen
Patient
polyclonal
respiratory
SARS-CoV-2
specificity
therapeutic targets
Variation
Zika virus
[DOI] 10.1038/s41587-021-00894-8 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41587-021-00894-8 PMC 바로가기 [Article Type] Article
Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures
SARS-CoV-2 및 H1N1 폐 손상의 공간 매핑은 차등 전사 서명을 식별합니다
Report
[키워드] Abstract
acute respiratory distress
acute respiratory distress syndrome
alveolar epithelium
anti-viral response
anti-viral responses
antiviral response
ARDS
Autopsy
both viruses
cellular
change
Coagulopathy
COVID-19
demonstrated
double infection
dual
enhanced
Extracellular
gene signature
H1N1
H1N1 influenza
identify
induced genes
infected individual
Influenza
Injury
leads
lung
Lung injury
lung tissue
Macrophage
macrophage activation
macrophages
pathway
patients with SARS-CoV-2
phenotype
platform
Post-mortem
Region
remodeling
respiratory distress
response
SARS-CoV-2
SARS-CoV-2 ARDS
SARS-COV-2 infection
SARS-CoV-2 infections
severe SARS
skewed
spatial transcriptomics
squamous metaplasia
syndrome
therapeutic target
therapeutic targets
tissue
tissue remodeling
transcriptional
transcriptional change
Transcriptome
transcriptomic
Type II pneumocyte
type II pneumocytes
unique
Vascular injury
vascular tissue
Viral
viral infections
[DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report
[DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report