Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumoniaResearch Article Published on 2021-08-232022-10-31 Journal: eLife [Category] COVID-19, MERS, [키워드] Analysis approach caused CD8 Cell Characteristics Cohort community-acquired pneumonia control subjects controls COVID-19 disease dysregulated eight etiology expand feature host response Human immune Influenza lack monocyte mononuclear cell natural killer cell non-infectious Pathogens Patient patients with COVID-19 PBMC performed Peripheral blood peripheral immune response phenotypic Pneumonia proteomic SARS-CoV-2 single-cell transcriptional transcriptomic type I unique [DOI] 10.7554/eLife.69661 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organsSARS-CoV-2 감염은 여러 기관의 다른 세포에서 인터루킨-17이 풍부한 전사 반응을 시작합니다Comparative Study Published on 2021-08-192022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus analyzed approach CCL20 cellular Computational biology and bioinformatics concerning coronavirus CXCL1 CXCL3 CXCL8 cytokine Cytokine storm Data analysis different cell different cells etiology global public health identify IL-17 immunology Infection infections Infectious diseases Inflammation information initiate Innate immunity interleukin lung molecular molecular mechanism multiple organ Other respiratory viruses pandemic pathogenic pathway Pathways potential therapeutic target potential therapeutic targets predict regulate respiratory RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway small molecule Small molecule inhibitors Systems biology the cytokine storm therapeutic intervention therapeutic interventions transcriptional response transcriptomic upregulated virus [DOI] 10.1038/s41598-021-96110-3 PMC 바로가기 [Article Type] Comparative Study
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection면역 체크포인트 억제제는 SARS-CoV-2 감염 동안 T 세포 면역을 증가시킵니다Research Article Published on 2021-08-182022-09-12 Journal: Science Advances [Category] MERS, SARS, 진단, 치료법, [키워드] adaptive Alter Antiviral CD8 cellular Cohort convalescent convalescent patient Convalescent patients COVID-19 COVID-19 pandemic COVID-19 patients demonstrated effector memory Evidence exacerbating expansion immune Immune checkpoint inhibitor Immune checkpoint inhibitors Immunity IMPROVE Infection Inflammation Inflammatory inhibitor interferon investigated Melanoma membrane nucleoprotein Patient profiles proteomic responses SARS-COV-2 infection severe COVID-19 Spike-specific antibody Spike-specific antibody responses Spread T cell T cell activation T cell response T cells transcriptomic treated Treatment type I interferon [DOI] 10.1126/sciadv.abg4081 PMC 바로가기 [Article Type] Research Article
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19성체 줄기 세포 유래 완전한 폐 오르가노이드 모델은 COVID-19에서 폐 질환을 모방합니다Tools and Resources Published on 2021-08-132022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] airway airway epithelia alveolar Alveolar Type II AT2 AT2 differentiation cause Cell cells center clinical Cohort Complete component computational COVID-19 COVID-19 pathogenesis Critical Diego disease modeling distal finding Host immune response Human human lung Illumina immune response immunologist in vitro include lung Lung disease lung organoid manuscript Medicine monolayer NIH NovaSeq 6000 pneumocyte Program proximal Respiratory samples responsible SARS-CoV-2 SARS-CoV2 scientist STEM supported sustained System therapy transcriptomic Vaccines viral infection virus viruses were infected widespread [DOI] 10.7554/eLife.66417 PMC 바로가기 [Article Type] Tools and Resources
The application of artificial intelligence and data integration in COVID-19 studies: a scoping reviewCOVID-19 연구에 인공 지능 및 데이터 통합 적용: 범위 검토Review Published on 2021-08-132022-09-11 Journal: Journal of the American Medical Informatics Associ [Category] 신약개발, 유전자 메커니즘, [키워드] adopted Algorithms Analysis applied approach article artificial intelligence coronavirus COVID-19 COVID-19 research Data analysis database datasets deep learning determine Diagnosis disease Drug discovery Early detection Electronic health records Factor Final genomic Health Organization help heterogeneous heterogenous IMPROVE item lack machine learning material media Medical imaging modeling natural language natural language processing neural networks outcome Precision PRISMA Prognosis proteomic qualitative analysis reduce Reporting review risk factor Risk factors searched social media Sociodemographic Support Surveillance systematic reviews transcriptomic World Health Organization [DOI] 10.1093/jamia/ocab098 PMC 바로가기 [Article Type] Review
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology
The trans-omics landscape of COVID-19COVID-19의 트랜스오믹스 환경Article Published on 2021-07-272022-09-10 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Analysis Antimicrobial responses arginine arginine depletion Asymptomatic Blood blood sample Blood samples characterization collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients Critically ill critically ill patients disease severity Gene regulation in immune cells genomic hallmark health emergency help heterogeneity Immunity Integrative analysis investigated metabolite metabolomic molecular neutrophil Neutrophils outbreak pathophysiology Patient patients Peripheral blood profile profiles proteomic public health threat reported selected Symptom Systems analysis T cell T cell dysfunction therapeutic strategy transcriptomic Tryptophan viral infection [DOI] 10.1038/s41467-021-24482-1 PMC 바로가기 [Article Type] Article
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets자동 기계 학습은 CovID-19 고역 처리량 데이터 세트의 예측 모델링을 최적화하고 가속화합니다.Article Published on 2021-07-232022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, [키워드] accelerate acute respiratory illness Analysis AUC Characteristics contribute COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets diagnostic disease effective eight feature Healthcare systems individuals Infectious diseases Innate interferon gamma machine learning management metabolomic mRNA Multiple nine Pathway analysis Pathways performed Predictive predictors prognostic proteomic public health reduced remained respiratory selected Signaling signature System therapeutic transcriptomic Viral [DOI] 10.1038/s41598-021-94501-0 PMC 바로가기 [Article Type] Article
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin이버멕틴에 의한 SARS-CoV-2 감염 중 임상 및 면역학적 결과의 약화Article Published on 2021-07-122022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, [키워드] airway airways Analysis Anosmia antigenic variant antigenic variants antiviral activity attenuation caused clinical condition Clinical deterioration coronavirus COVID‐19 dampen death disease distress Efficacy golden hamsters hamsters Host immunological immunology immunomodulatory activity immunomodulatory drug immunomodulatory drugs IMPROVE induce Inflammation inflammatory pathways Inflammatory response Ivermectin lead limit Lower respiratory tract lung lung tissue Macrophage Microbiology, Virology & Host Pathogen Interaction modulate modulating modulation no effect olfactory outcome pandemic pathophysiology pathway patients Prevent promote pulmonary symptoms reduce respiratory respiratory distress response SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 Severe case severe cases severity Standard dose Support the disease therapy transcriptomic Transcriptomic analyses type I interferon upper and lower respiratory tracts Vaccine Viral viral infections Viral load [DOI] 10.15252/emmm.202114122 PMC 바로가기 [Article Type] Article
Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning MethodsResearch Article Published on 2021-07-062022-10-27 Journal: BioMed Research International [Category] [키워드] Accuracy analysed Analysis applied asymptomatic patients Bacterial infection Biomarker build candidate gene caused classification algorithm Classifier Clinical use coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 diagnosis dataset Diagnosis diagnosis of COVID-19 Diseases Efficacy extension healthy control Host identify identifying IMPROVE infected with SARS-CoV-2 Infection Influenza initial machine learning machine learning model other respiratory infections pathogenic Patient presymptomatic released required respiratory infectious disease resulting severe respiratory disease Spread susceptible Symptom Symptoms transcriptomic virus with COVID-19 [DOI] 10.1155/2021/9939134 PMC 바로가기 [Article Type] Research Article