Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysisSystematic Review Update Published on 2021-06-302022-10-28 Journal: Systematic Reviews [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission age association behavioural calculated Comorbidities Comorbidity Comprehensive conditions Course COVID-19 COVID-19 cases COVID-19 disease COVID-19 hospitalisation COVID-19-associated hospitalisation COVID-19-associated mortality death decrease demographics disease Diseases Effect Effect modification estimate estimates Evidence explained Factor Health heterogeneity high risk hospitalisation hypertension ICU ICU admission individual intensive care Interaction International Intervention less magnitude median age meta-analyses Meta-analysis meta-regression Modification National NPI performed quantitative synthesis recommendation renal reported required Result risk risk factor robust severe COVID-19 Severity of disease significantly Study participants study population supplementary material systematic review target Vaccination strategies Vaccination strategy [DOI] 10.1186/s13643-021-01732-3 PMC 바로가기 [Article Type] Systematic Review Update
Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring전세계 6 개월의 전세계 모니터링을 통한 관련 SARS-COV-2 게놈 변이Research Article Published on 2021-06-292022-09-10 Journal: BioMed Research International [Category] 변종, 진단, [키워드] Analysis analyzed Antiviral treatment Asia changed Cluster Clustering analysis D614G diagnostic event Evolution of SARS-CoV-2 False-positive Frequency Genome Genome sequencing geographical location GISAID database hotspot information monitoring Month Mutation nonsynonymous mutation Nsp12 NSP2 occurred Oceania ORF3a outbreak pandemic provide Q57H reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes the SARS-CoV-2 transition transition mutations Vaccination strategies variant Variation was used [DOI] 10.1155/2021/5553173 PMC 바로가기 [Article Type] Research Article
Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide MonitoringResearch Article Published on 2021-06-292022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Analysis analyzed Antiviral treatment Asia changed Cluster Clustering analysis D614G diagnostic event Evolution of SARS-CoV-2 False-positive Frequency Genome Genome sequencing geographical location GISAID database hotspot information monitoring Month Mutation nonsynonymous mutation occurred Oceania ORF3a outbreak pandemic provide Q57H reference genome SARS-CoV-2 SARS-CoV-2 genome the SARS-CoV-2 transition Vaccination strategies variant Variation was used [DOI] 10.1155/2021/5553173 PMC 바로가기 [Article Type] Research Article
Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide MonitoringResearch Article Published on 2021-06-292022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Analysis analyzed Antiviral treatment Asia changed Cluster Clustering analysis D614G diagnostic event Evolution of SARS-CoV-2 False-positive Frequency Genome Genome sequencing geographical location GISAID database hotspot information monitoring Month Mutation nonsynonymous mutation occurred Oceania ORF3a outbreak pandemic provide Q57H reference genome SARS-CoV-2 SARS-CoV-2 genome the SARS-CoV-2 transition Vaccination strategies variant Variation was used [DOI] 10.1155/2021/5553173 PMC 바로가기 [Article Type] Research Article
Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans인간의 SARS-CoV-2 감염에 대한 중화 항체 반응의 동역학 및 상관 관계Article Published on 2021-06-092022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, 치료기술, [키워드] age antibody antibody kinetics Antibody Response broad spectrum correlates of neutralization COVID-19 COVID-19 pandemic Critical cross-neutralizing demonstrated disease severity evaluated exceptional exhibiting Gender half-live half-lives Human IgG IgG antibody individual individuals Infection initial key factor Kinetics longitudinal cohort Mild multivariate neutralization Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing antibody response purified reactivity SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2-neutralizing antibody serum Spike protein statistical sustained symptomatic infection understanding Vaccination strategies virus spike protein [DOI] 10.1016/j.chom.2021.04.015 PMC 바로가기 [Article Type] Article
Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variantVOC-202012/01의 죽음 — SARS-CoV-2 변종 사망 사례의 다중 모드 조사Case Reports Published on 2021-06-052022-09-10 Journal: International Journal of Legal Medicine [Category] MERS, SARS, 변종, [키워드] 501Y.V1 acute respiratory distress syndrome B.1.1.7 B.1.1.7 lineage Complication comprehensive analysis conducted Coronavirus-disease-19 country death case death cases described Dying initiated lung damage macroscopic pandemic Patient Postmortem predominant pulmonary damage Pulmonary embolism pulmonary embolisms radiologic reported respiratory respiratory distress Respiratory distress syndrome respiratory infections SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 the disease the SARS-CoV-2 today Vaccination strategies Vaccination strategy variant Variant of Concern-202012/01 variants VOC-202012/01 [DOI] 10.1007/s00414-021-02618-8 PMC 바로가기 [Article Type] Case Reports
Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patientsCOVID-19 환자로부터 SARS-CoV-2 ORF8 단백질의 선형 B 세포 에피토프 마이닝Research Article Published on 2021-06-032022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] Alpha antibody approach B cell epitope B-cell characterized COVID-19 COVID-19 disease COVID-19 patient diagnostic diagnostics epitope IgG immunization immunodominant immunogenic in vivo linear linear epitope ORF8 ORF8 protein overlapping pandemic virus peptide peptide-based peptides Region SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2-infected patients sensitivity sera serological seropositive target vaccination Vaccination strategies Viral protein [DOI] 10.1080/22221751.2021.1931465 PMC 바로가기 [Article Type] Research Article
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios산모 및 신생아 제대혈 SARS-CoV-2 항체 및 태반 전달 비율 평가Article Published on 2021-06-012022-09-11 Journal: JAMA Pediatrics [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed antibody antibody concentration Antibody concentrations Antibody Response antibody transfer Asian assessment association Asymptomatic black Blood blood specimen Clinical data cohort study Combination Concentration CORD Cord blood coronavirus coronavirus disease Coronavirus disease 2019 correlated Demographic and clinical data during pregnancy enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Hispanic IgG IgG antibody IgM IgM antibodies IgM antibody Immunity Infant Infants Infection interquartile range management Maternal maternal antibody median Mild moderate mother Neonatal Newborn outcome parturient Philadelphia Placenta positively correlated Pregnancy Ratio receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody SARS-CoV-2 spike protein sera seronegative seropositive severe acute respiratory syndrome Coronavirus severe coronavirus disease significantly lower specimen Spike protein study cohort subsequent symptomatic infection the receptor-binding domain the SARS-CoV-2 time of delivery took place transfer transferred understanding Vaccination strategies were measured white women [DOI] 10.1001/jamapediatrics.2021.0038 PMC 바로가기 [Article Type] Article
Predictive Markers of Immunogenicity and Efficacy for Human VaccinesReview Published on 2021-06-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adopted animal model applied approach coronavirus Data analysis develop Efficacy effort help high-throughput technologies Human human populations humans identifying immune immune signature Immunity immunogenicity in silico in vivo imaging increasingly machine learning malaria marker methodology Pandemics Pathogens preclinical models preclinical study Predictive predictive biomarkers Predictive model probe protective responses Research responses SARS-CoV-2 Systems biology systems immunology translational Tuberculosis unsupervised analyses vaccination Vaccination strategies Vaccine vaccine candidate vaccine signatures Vaccines Zika virus [DOI] 10.3390/vaccines9060579 PMC 바로가기 [Article Type] Review
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석Report Published on 2021-05-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법, [키워드] CD4 Clonal analysis clone clones conserved Coronaviruses cross-reactive cross-reactivity effector Endemic epitope Epitopes helper HLA-DP HLA-DR identify immunodominance immunodominant individual individuals memory T cells nucleoprotein processed robust S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants Subunit vaccine subunit vaccines T cell T cell epitope T cell epitopes T cell response T cells the RBD Vaccination strategies Vaccination strategy [DOI] 10.1126/science.abg8985 PMC 바로가기 [Article Type] Report