Process-based diagnostics of extreme pollution trail using numerical modelling during fatal second COVID-19 wave in the Indian capitalResearch article Published on 2022-07-012022-10-05 Journal: Chemosphere [Category] COVID19(2023년), SARS, 진단, [키워드] Anomaly conducted COVID-19 diagnostics Emissions ENhance events experiment extreme Frame help India initial Interpretation Local lockdown magnitude Model Mortality New outbreak Particulate matter remained responsible SAFAR sensitivity significantly Transport Variation WRF-Chem [DOI] 10.1016/j.chemosphere.2022.134271 [Article Type] Research article
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysisSARS-CoV-2 항체 수준의 종단적 변이와 바이러스 변이체의 출현: 혈청학적 분석Article Published on 2022-07-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] absence Analysis antibody antibody levels Antibody Response Antibody responses Antibody titre assays baseline Clinical practice Cohort correlation correlation analyses COVID-19 vaccine declined detectable Deterioration determine determined by Effect facilitate functional Immunity individual Infection longitudinal MONITOR National Health Service neutralisation activity neutralisation assays neutralising Neutralising activity neutralising antibody titre neutralising antibody titres nucleocapsid participants with SARS-CoV-2 Post-infection predict Predictive Predictive value presence or absence SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivities sensitivity serological analysis Serological assay serological assays serological measurement serological measurements serological test Serological tests serum sample serum samples Spearman Spike protein Spike protein sequence subsequent Surrogates the spike protein These data threshold timepoint timepoints titres two-tailed variants variants of concern Variation Viral viral variant Viral variants [DOI] 10.1016/S2666-5247(22)00090-8 PMC 바로가기 [Article Type] Article
International trends in prescription opioid sales among developed and developing economies, and the impact of the COVID-19 pandemic: A cross-sectional analysis of 66 countriesArticle Published on 2022-07-012022-10-04 Journal: Pharmacoepidemiology and drug safety [Category] 신약개발, [키워드] 95% CI 95% confidence interval Analysis conducted country COVID-19 COVID-19 pandemic cross-sectional analysis declined drug policy Impact impacted increase in management MONITOR Pain pandemic prescription opioids. Rate reduced Retrospective cross-sectional study stratified trajectory Variation [DOI] 10.1002/pds.5443 PMC 바로가기 [Article Type] Article
Immunoinformatic paradigm predicts macrophage and T-cells epitope responses against globally conserved spike fragments of SARS CoV-2 for universal vaccination면역 정보 패러다임은 보편적 백신 접종을 위해 SARS CoV-2의 전 세계적으로 보존된 스파이크 단편에 대한 대식세포 및 T 세포 에피토프 반응을 예측합니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] allele antigenicity bioinformatics CD4+ CD4+ cells conserved country COVID-19 COVID-19 case COVID-19 cases D614G Delta develop Effect epitope Epitopes examined facilitated glycosylation H-bonding help highest HLA-DRB5 IC50 IEDB immunogenicity In silico mutation and antigenicity in some in-silico Inconclusive increase interactions introduced Macrophage MHC class MHC class and CD4+ cells MHC class II MHC-II mutant Mutation omicron predict Proteases reactivity receptors representation response responses against RMSD RMSD plot SARS CoV SARS CoV-2 SARS CoV-2 spike protein SARS-CoV-2 SARS-CoV-2 spike screened Screening sequence Spike protein stability SVMTriP T-cell Universal universal vaccination vaccination Vaccination strategy Vaccine variants Variation VaxiJen V2.0 [DOI] 10.1016/j.intimp.2022.108847 PMC 바로가기 [Article Type] Article
Impact of COVID-19 lockdown on glucemic control in children and adolescents with type 1 diabetes mellitusObservational Study Published on 2022-07-012022-10-05 Journal: Anales de pediatria [Category] COVID19(2023년), SARS, 임상, [키워드] age baseline blood glucose children Cohort Complication Confinamiento Continuous Continuous glucose monitoring Control Control glucémico coronavirus COVID-19 Daily Diabetes Mellitus Diabetes tipo 1 Edad pediátrica English evaluate Evolution Flash Flash glucose monitoring Glucose glycemic control hyperglycemia hypoglycemia Impact information insulin interstitial lockdown media monitoring systems Monitorización continua de glucosa Monitorización flash de glucosa multiple dose Pandemia pandemic parental Patient Pediatric age physical quarantine Regular remained Retrospective study SARS-CoV2 significantly Spain Spanish Spread subsequent T1D the disease therapy time treated Type 1 diabetes Variation was collected were assessed [DOI] 10.1016/j.anpede.2020.12.022 PMC 바로가기 [Article Type] Observational Study
SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)Article Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant variants variants of concern variants of interest Variation viral infection virus VOCs VOIs [DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article
Factors associated with, and variations in, COVID-19 hospital death rates in England’s first two waves: observational studyObservational Study Published on 2022-06-302022-10-04 Journal: BMJ Open [Category] 임상, [키워드] accounted adjusted Admission adult intensive & Care Comorbidities correlation COVID-19 COVID-19 admission Critical Critical care death death rate death rates diagnosis of COVID-19 England Factor Factors Health hospital Hospital Episode Statistics hypertension Intensive Length limits median moderate mortality rate obesity observational study Odds ratio outlier Patient peaked predictor Quality quality in health care random second wave significantly variable Variation Wave [DOI] 10.1136/bmjopen-2021-060251 PMC 바로가기 [Article Type] Observational Study
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other LineagesCOVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다Article Published on 2022-06-292022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, [키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19 [DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article
Evaluating the Ability to ID (COVID-19) NOW: a Large Real-World Prospective Evaluation of the Abbott ID NOW COVID-19 Assay(COVID-19) NOW 식별 능력 평가: Abbott ID NOW COVID-19 분석에 대한 대규모 실제 전향적 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Abbott Ability Admitted Patient admitted patients Affect applicability assist Canada chain changed Cohort Community COVID-19 COVID-19 admission Critical decrease disease dual epidemiological evaluated Evaluating facilitate Factor Factors false negatives False positive highest hospital ID NOW increase in individual infection control Laboratory limitation molecular test multisite Negative predictive value not high pandemic Patient patient cohorts POCT point-of-care positive predictive values presenting Prevalence Probability Prospective public health Rapid Rapid test rapid testing Rapid tests receipt reduced reference standard report Reporting reverse transcriptase reverse transcriptase PCR risk RT-PCR SARS-CoV-2 SARS-CoV-2 detection status Study design swabs symptom onset TAT theory Tolerance Transmission Triage true negative turnaround time turnaround times utility Variation variations Volume [DOI] 10.1128/spectrum.00513-22 PMC 바로가기 [Article Type] Article
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spikeSARS-CoV-2 Omicron BA.2 스파이크의 Cryo-EM 구조Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody binding antibodies coronavirus CP: Microbiology cryo-EM Cryoelectron microscopy determine domain ectodomain epitope Epitopes functional fusion peptide hallmark immune immune evasion induce Interaction less Lineage Microbiology Microscopy Mutation neutralize omicron Omicron BA.2 Omicron variant peptide proportion Protein Pseudovirus neutralization assay RBD Receptor binding domain Region remodeling respiratory resulting S proteins SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus Structure structures the RBD underlie variant Variation [DOI] 10.1016/j.celrep.2022.111009 PMC 바로가기 [Article Type] Article