Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?인간 난모세포는 ACE2와 BSG 유전자와 해당 단백질을 모두 발현합니다: SARS-CoV-2 감염이 가능합니까?Review Published on 2021-02-012022-09-12 Journal: Stem cell reviews and reports [Category] MERS, 진단, [키워드] ACE2 addition Affect Alter animal models BSG COVID-19 COVID-19 disease expressed facilitate Human humans hypothetical in vitro infect Infection molecular Oocyte oocytes previous study Proteins proteome question SARS-CoV-2 SARS-COV-2 infection Transcriptome virulent virus [DOI] 10.1007/s12015-020-10101-x PMC 바로가기 [Article Type] Review
Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다Research Article Published on 2021-01-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent [DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article
Strategies for Vaccination: Conventional Vaccine Approaches Versus New-Generation Strategies in Combination with AdjuvantsReview Published on 2021-01-222022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] absence adjuvant adjuvants adopted Antigen Antiviral treatment applied approach caused Combination Conventional COVID-19 pandemic develop disadvantage DNA vaccine effective Effective vaccines ENhance expressed Genetic group inactivated initial mRNA mRNA stability nanoparticle outbreak pathogen peptides Protein Proteins Psychological raised Research retroviral RNA RNA vaccine SARS-CoV-2 Spread Strategy suppress transfer Vaccine vaccine adjuvant Vaccine development Viral vector virulent virus [DOI] 10.3390/pharmaceutics13020140 PMC 바로가기 [Article Type] Review
Differential expression and correlation analysis of miRNA–mRNA profiles in swine testicular cells infected with porcine epidemic diarrhea virusArticle Published on 2021-01-212022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis bacterial invasion Bioinformatics analysis Cell Cell Biology Cellular signalling networks Computational biology and bioinformatics Control correlated correlation Correlation analysis Cytoscape DE miRNA DE miRNAs DESeq differential expression differentially expressed epidemic diarrhea Epigenetic epithelial cells expression expression pattern Gene regulatory networks group groups High-throughput screening Host immune response Immunity in vitro induce Infection Interaction involved mechanism Mechanisms of disease microRNA miRanda miRNA miRNA expression mRNA mRNAs Next-generation sequencing NF-κB signaling NGS Pathogenesis pathway PEDV performed polymerase chain predicted profile qRT-PCR Quantitative R package Randomly reverse transcription selected sequencing data Strains variant viral pathogenicity virulent virus [DOI] 10.1038/s41598-021-81189-5 PMC 바로가기 [Article Type] Article
Eastern Cape Healthcare Workers Acquisition of SARS-CoV-2 (ECHAS): Cross-Sectional (Nested Cohort) Study Protocol이스턴 케이프 의료 종사자 SARS-CoV-2(ECHAS) 획득: 횡단면(중첩 코호트) 연구 프로토콜Protocol Published on 2021-01-052022-09-10 Journal: International Journal of Environmental Research an [Category] 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition African Antenatal antibody antibody assay antibody levels Cape Chain Reaction Clinical characteristics Cluster CMIA Cohort cohort study Community community infection conducted Coronavirus-2 country COVID-19-related death cross-sectional cross-sectional study cumulative decay Department Eastern Cape Effectiveness Fatality rate finding HCW HCWs Health health facilities healthcare worker Healthcare workers highlight humoral immune response identify IgG antibodies IgG antibody immunoassay increased risk independent risk factor independent risk factors Infection Infection prevention infection rate logistic regression models longitudinal change longitudinal changes measure Microparticle offer pandemic participant polymerase chain polymerase chain reaction positive Prevention and control PROTECT Protein qualitative detection questionnaire recruited Regression model Reinfection respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 RT-PCR SARS-CoV-2 serology SARS-CoV-2 seroprevalence second wave selected serology South South Africa tested the SARS-CoV-2 virulent women worker [DOI] 10.3390/ijerph18010323 PMC 바로가기 [Article Type] Protocol
Contributory role of SARS-CoV-2 genomic variations and life expectancy in COVID-19 transmission and low fatality rate in AfricaResearch Published on 2020-12-092022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] accumulation Africa African age Analysis analyzed average Characteristics claimed contributed coronavirus country COVID-19 COVID-19 transmission D614G database death drug resistance economic devastation Epidemiology Factor Factors fatality Fatality rate Genomic variability genomic variation GISAID Health health care systems highest Host incidence infected patient initiative Invasion lockdown Low fatality Mutation mutational hotspot mutations novel coronavirus disease nucleocapsid Older outbreak pandemic predicted Prevalence prevalence of COVID-19 public health recurrent mutation Region Regulatory Result RNA-dependent RNA polymerase SARS-CoV-2 selective sequence Sequencing spike glycoprotein Strains the disease the SARS-CoV-2 Transmissibility viral sequence virulent virus [DOI] 10.1186/s43042-020-00116-x PMC 바로가기 [Article Type] Research
Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2530 Published on 2020-11-242022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] accelerate activated acute respiratory syndrome approach assays automated bind can be used cleave clinical samples complex complexes coronavirus COVID-19 CRISPR CRISPR Diagnostics diagnostic Diagnostic method diagnostic methods diagnostic test diagnostics disease spread Diseases DNA enzyme gRNA guide RNA imperative infected patient isotachophoresis isothermal amplification limitation Microfluidics molecular Nasopharyngeal swab nucleic acid extraction offer Pandemics pathogen detection Pathogens Prevent probe purification Rapid rapid testing reporter reporters respond RNA SARS-CoV-2 SARS-CoV-2 RNA selective Significance single-stranded DNA specificity Spread spread of COVID-19 virulent [DOI] 10.1073/pnas.2010254117 PMC 바로가기 [Article Type] 530
Current status on treatment options for feline infectious peritonitis and SARS-CoV-2 positive catsReview Published on 2020-11-132022-10-28 Journal: The Veterinary Quarterly [Category] COVID-19, MERS, SARS, [키워드] Antiviral antiviral drugs antiviral therapy approach cat caused Clinical effect Clinical sign coronavirus current feline Feline infectious peritonitis Feline infectious peritonitis virus FIP GS-441524 immune response immune system immune-mediated disease immunomodulator immunosuppressive agent increased survival information pandemic patients pharmacological positive Protease inhibitor provide reduce resulting robust SARS-CoV-2 stimulate Therapeutics treat Treatment viral-induced virulent virus [DOI] 10.1080/01652176.2020.1845917 PMC 바로가기 [Article Type] Review
Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL proteaseResearch Article Published on 2020-11-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] 3CL 3CL Protease addition Analysis antiviral activity cause Cell cells cleavage diarrhea disease docking drugs epidemic diarrhea examined gastroenteritis in vitro indicate infections inhibit inhibiting effect Interaction isothermal titration calorimetry ITC molecular myocarditis PEDV PEDV replication polyprotein predicted Prevent Prophylactic protease Protease activity PROTECT Replication reproductive screened SVA syndrome TGEV therapeutic therapeutic strategy tomatidine Vaccine variants Vero virulent virus virus replication was determined western blot [DOI] 10.1186/s13567-020-00865-y PMC 바로가기 [Article Type] Research Article
A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methodsReview Published on 2020-11-032022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] 3CLpro Abstract Anti-viral antibiotic applied binding biological activity candidate cause caused complexes computational method COVID-19 pandemic cysteine protease derivatives drug drug-repurposing functional generate identify imperative in silico in silico Approach Infection information inhibit inhibitor inhibitors interacting residues interaction pattern intermolecular interaction Ligand-based virtual screening (LBVS) ligand-bound molecular nucleotide analogues parameter peptides potential therapeutic agent protease protease inhibitors Proteins provide replicase polyprotein SARS-CoV-2 shown stability Structure Structure-based virtual screening (SBVS) structures therapeutic viral replication Virtual screening virulent virus [DOI] 10.1186/s43141-020-00085-z PMC 바로가기 [Article Type] Review