microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro *Research Published on 2018-02-072022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus, [키워드] Accessory activating Activation addition adopted aggravate Analysis Cell damage demonstrated diarrhea differentially expressed downregulated Effect elevated expression IL1RAP Infection interleukin-1 investigated kidney MAPK mitochondrial Mitochondrial function mitochondrial membrane potential p38 MAPK signaling pathway PK-15 positive previous study Protein proteomic Quantitative RB1 receptor reduced Regulatory retinoblastoma suppressed target targeting TGEV transmissible gastroenteritis virus upregulated Via [DOI] 10.1074/mcp.RA117.000432 PMC 바로가기 [Article Type] Research
A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations사례 대조 붕괴 분석은 새로운 돌연변이에 초점을 맞춘 트리오 시퀀싱 연구와 관련된 간질 유전자를 식별합니다Research Article Published on 2017-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition adopted Analysis approach can be used Case-control Collapsing controls datasets de novo de novo mutation de novo mutations disease disorders dominant effective enrichment epilepsy epileptic encephalopathy evaluate Exome expected filtered form Genes genome-wide significance identify implicated KCNT1 large cohort life majority Mutation offer parent parents pathogenic performed predicted proportion Protein protein-coding gene protein-coding genes rare variant responsible Sample size sample sizes SCN2A selected sequence Sequencing significantly significantly higher STXBP1 Support Trio variant variants Variation [DOI] 10.1371/journal.pgen.1007104 PMC 바로가기 [Article Type] Research Article
Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcinctaTeladorsagia circumcincta에서 필드 파생 다중 구충제 내성의 게놈 유전자 이입 매핑Research Article Published on 2017-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adopted affecting Analysis analyzed candidate gene changes in Chemotherapy complex contribute copy number drug resistance drugs eradication Evidence Evolution expression facilitated Factor framework Genes Genetic genetic architecture genetic background genetic factors Genotype humans identify increasingly lead livestock mechanism Multidrug resistance multidrug resistant multifactorial pair parasite parasites parasitic nematode parasitic nematodes pathogen performed polymorphism Population progeny prophylactic treatment Putative mechanisms Quantitative reduced Region regulatory region repeated resistance gene responsible sensitivity sheep single gene strain susceptibility susceptible Variation variety whole-genome widespread [DOI] 10.1371/journal.pgen.1006857 PMC 바로가기 [Article Type] Research Article
HexaPrime: A novel method for detection of coronavirusesArticle Published on 2012-12-072022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] addition adopted amplification assays cDNA synthesis conserved coronavirus Coronaviruses described develop diagnostic DNA effort etiological facilitate HexaPrime high variability human disease identify manuscript oligonucleotide overcome regions RNA fragment RNA virus RNA viruses sequence tested universal primer viral nucleic acid virus virus discovery viruses [DOI] 10.1016/j.jviromet.2012.11.039 PMC 바로가기 [Article Type] Article
A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E ProteinResearch Article Published on 2012-05-032022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activities adopted affected Antiviral strategies Author coronavirus correlated defined different disrupt disrupting domain E protein examined found function functions Golgi Host hydrophobic IBV identify Impact implicated in vitro independent infected cells Infection infectious Infectious Bronchitis Virus Infectious virus less mapped mechanism of action membrane membrane protein mutant occur Particle Particles predicted promote Protein reported required residue secretory pathway Substitution thought Topology transmembrane virion assembly virus [DOI] 10.1371/journal.ppat.1002674 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV ReplicationResearch Article Published on 2008-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adopted assays biochemical complex coronavirus Coronavirus replication detected domain expressing found function in vitro Interaction Involvement mammalian mechanism molecular mechanisms multifunctional Nidovirale non-structural protein Nsp12 nsp14 Nsp3 platform Protein protein-protein interaction Proteins provided regulate reporter RNA genome SARS Coronavirus SARS-CoV sequence shown stimulated to screen Transcription unique Viral protein viruses [DOI] 10.1371/journal.pone.0003299 PMC 바로가기 [Article Type] Research Article
Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, ItalyResearch Article Published on 2007-02-202022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] Acute respiratory infection adopted amplified fragment approach assay Asthma Bronchiolitis bronchitis bronchopneumonia children circulation Co‐infection Department described detected detection Diagnosis enrolled Hospitalized Inc infected children Infection influenza type A involved Italy métapneumovirus molecular NL63 Novel coronavirus parainfluenza virus pathogen Patient Pneumonia positive result respiratory pathogen respiratory syncytial virus respiratory tract infection respiratory virus reverse transcription rhinovirus Rome RSV RT‐PCR sequenced the patient to define viral pathogen virus [DOI] 10.1002/jmv.20832 PMC 바로가기 [Article Type] Research Article
Pseudoknots: RNA Structures with Diverse FunctionsPrimer Published on 2005-06-142022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] adopted function motifs prevalent Protein RNA RNA molecules Structure [DOI] 10.1371/journal.pbio.0030213 PMC 바로가기 [Article Type] Primer