susceptibility – Page 118 – Communicable Diseases Research

Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species

종에 걸친 안지오텐신 전환 효소 2 매개 SARS-CoV-2 진입 평가

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Biological Chemistry [Category] 변종, 유전자 메커니즘,

Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones

COVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬

Review

Published on 2021-01-012022-09-11
Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 Activation ADAM17 added angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral response Biological canonical cardiovascular disease caused contribute coronavirus COVID-19 COVID-19 pandemic Critical dependent on disease disease pathogenesis disease severity disintegrin epidemiological data exacerbate female females Gender genetics Health highlight increase in increasingly innate immune response innate immune system involved leads Loss male mechanism membrane metalloproteinase Mortality outcomes Pathways plasma positive positive feedback potential mechanism potential mechanisms protective mechanism proteolytic cleavage RAS receptor Renin renin-angiotensin system SARS epidemic SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection severe disease Sex sex differences sex hormone Sex hormones susceptibility the SARS-CoV-2 Viral viral entry worsened
[DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review

Understanding the genetic determinant of severity in viral diseases: a case of SARS-Cov-2 infection

Review

Published on 2020-12-312022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

[키워드] Abstract ACE2 Admission Affect age Angiotensin-converting enzyme 2 (ACE2) gene Asymptomatic Clinical outcome clinical response clinical variability co-morbidity condition contribute coronavirus COVID-19 Diagnosis disease disease severity effort Factor Factors Genetic help HLA human gene Human genetics Human leucocyte antigen (HLA) allele hypothetical ICU identify in viral increased risk Infection intensive care life threatening mild infection Mutation Numerous occur outbreak outcome pandemic Patient Prophylaxis question reported Research SARS-CoV-2 Severe infection severity shown significantly susceptibility target the disease the SARS-CoV-2 therapy TLR TLR3 TLR7 Toll-like receptor (TLR) understanding unique variant Variation viral infection viral infections
[DOI] 10.1186/s43042-020-00122-z PMC 바로가기 [Article Type] Review

Knowledge, Perceived Beliefs, and Preventive Behaviors Related to COVID-19 Among Chinese Older Adults: Cross-Sectional Web-Based Survey

Original Paper

Published on 2020-12-312022-10-30
Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS,

Markers Associated with COVID-19 Susceptibility, Resistance, and Severity

Review

Published on 2020-12-302022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

Mucin signature as a potential tool to predict susceptibility to COVID‐19

COVID-19에 대한 감수성을 예측하는 잠재적 도구로서의 뮤신 시그니처

Review

Published on 2020-12-292022-09-10
Journal: Physiological Reports [Category] MERS, 유전자 메커니즘, 진단,

[키워드] Asymptomatic Biomarker cells component Corona COVID‐19 COVID‐19 patients Critical cytokine Cytokines Economy expression glycome Health help highlight host cells identify individual individuals Infection Infectious disease Inflammation Innate immunity involved lead Measures Mild molecular mucin mucins new virus pandemic pathogenicity Pathogens pathology Patient predict progression Protein quarantine quarantine measures recent receptor receptors regulated respiratory response to therapy SARS‐CoV‐2 severe symptom severe symptoms susceptibility symptomatic the cells therapy upper respiratory tract virus viruses
[DOI] 10.14814/phy2.14701 PMC 바로가기 [Article Type] Review

Statistical power in COVID-19 case-control host genomic study design

COVID-19 사례 대조군 숙주 게놈 연구 설계의 통계적 힘

Correspondence

Published on 2020-12-282022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] Accuracy Case-control COVID-19 detect disease severity disease severity of COVID-19 early stage early stages effect sizes Epidemiology estimate Factor feasibility Genetic Genetic epidemiology genetic factors genetic finding genetic findings Genetic studies Genetic variant Genetic variation Genome-wide association studies genomic Host Impact Infection Infectious disease information Interpretation moderate pandemic phenotypic data risk stratification SARS-CoV-2 SARS-COV-2 infection severity significantly Simulation Statistical genetics Study design supplementary material susceptibility therapeutic Treatment Vaccine development
[DOI] 10.1186/s13073-020-00818-2 PMC 바로가기 [Article Type] Correspondence

Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update

Review

Published on 2020-12-282022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] “cytokine storm” ACE2 acute respiratory syndrome addition affected angiotensin-converting enzyme 2 association clinical manifestation consequence coronavirus COVID-19 COVID-19 patient disease Dysbiosis Evidence Gut gut microbiota gut microbiota dysbiosis hospital human cell immune immune response immune system Increased infect Inflammation inflammatory condition intensive care intestinal knowledge microbiota modulated Older outcome Patient patients phenotype Poor presenting Prevalence pulmonary diseases renal SARS-CoV-2 severe cases Stage suggested susceptibility susceptibility to progress the disease the patient virus receptor
[DOI] 10.3390/microorganisms9010053 PMC 바로가기 [Article Type] Review

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

유전적 배경과 PfKelch13은 Plasmodium falciparum에서 PfCoronin 돌연변이의 artemisinin 감수성에 영향을 미칩니다

Research Article

Published on 2020-12-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect African Analysis Artemisinin Asia Biology can not clinical isolates combination therapies combination therapy continent develop domain drug pressure drug resistance Effect elevated Evidence evidence of Evolution focus Future Genetic genetic analysis genetic background genetic determinant genetic determinants Health in vitro independent isolate Laboratory malaria Mask mutant Mutation no evidence of parasite parasites pathway phenotype Plasmodium falciparum Protein reduced referred to representing selected selection pressure South America Spread standard treatment strain survival susceptibility synergy tested Transmission
[DOI] 10.1371/journal.pgen.1009266 PMC 바로가기 [Article Type] Research Article

Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2

Research Article

Published on 2020-12-262022-10-31
Journal: Heliyon [Category] COVID-19,