Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infectionArticle Published on 2022-09-202022-10-06 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] Analysis Antiviral treatment B cell Course disease escape mutations fixed Frequency genomic high risk hospitalized patient Infection intra-host evolution Mutation mutations Patient performed Prolonged infection prolonged SARS-CoV-2 infection Remdesivir remdesivir treatment. respiratory sample RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 severe disease progression treat Treatment treatment guideline variant [DOI] 10.1016/j.xcrm.2022.100735 PMC 바로가기 [Article Type] Article
Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concernArticle Published on 2022-09-172022-11-15 Journal: Journal of Travel Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome addition Antigen B cells B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 baseline Beta binding binding antibodies binding antibody coronavirus country COVID-19 Delta elevated examined healthcare humoral immune response IgA IgA response IgG Immunity India induce Infection investigated limit of detection Lineage Month Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron persistence SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 sustained the SARS-CoV-2 vaccination Vaccine variant variants of concern wild type Wuhan [DOI] 10.1093/jtm/taac088 PMC 바로가기
Canakinumab in patients with COVID-19 and type 2 diabetes – A multicentre, randomised, double-blind, placebo-controlled trialArticle Published on 2022-09-172022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] 1:1 95 % CI Activation addition Administered adverse event approach assigned Basel blockade BMI canakinumab Clinical outcome contributing to COVID-19 CRP Dexamethasone diabetes died dose double-blind dropped drug Efficacy foundation glycaemic control higher risk hospitalised Hospitalization Hyperinflammatory ICU IL-1beta IL-1β IL-6 IMPROVE Inflammasome innate immune system interleukin-1β intravenous dose less medication multicenter multicentre Novartis Obesitiy. obesity outcome participant Patient patients treated patients with COVID-19 Placebo placebo group placebo-controlled trial primary analysis randomised randomization Randomly reduction Registered reported required SARS-CoV2 SARS-CoV2 infection Science Seven severe COVID-19 significantly Standard-of-care statistically significant statistically significant difference survival Switzerland systemic inflammation tested treated Treatment type 2 diabete university Ventilation with COVID-19 [DOI] 10.1016/j.eclinm.2022.101649 PMC 바로가기 [Article Type] Article
Estimating deaths averted and cost per life saved by scaling up mRNA COVID-19 vaccination in low-income and lower-middle-income countries in the COVID-19 Omicron variant era: a modelling studyArticle Published on 2022-09-132022-11-16 Journal: BMJ Open [Category] SARS, 변종, [키워드] Analysis conducted country COVID-19 COVID-19 vaccination COVID-19 vaccine death deaths distribution dose Effectiveness effort epidemiological estimate expected mortality fatality Health health economics Infection Lower magnitude mRNA mRNA vaccine omicron outcome parameter potential benefit Public public health SARS-CoV2 Scaling sensitivity analysis Spread statistical vaccination Vaccine variant were expressed while [DOI] 10.1136/bmjopen-2022-061752 PMC 바로가기
Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccineArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] all age group animal models Antigen approach Asymptomatic Attenuated benefit catch caused center Characteristics common cold Control did not reduce drug effective effort Engineering Express healthy Hospitalization hosts Human Human rhinovirus immune response Immunity induce Infection intranasal intranasal vaccination live vaccine Mortality mucosal nasal swab pandemic coronavirus pathogen pathogenic prevention Protective Proteins reducing Replication replication competent respiratory virus rhinovirus rhinoviruses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 serotype serum Social distancing measure Spread strain tested Vaccine vaccine candidate vector virus [DOI] 10.3389/fimmu.2022.871463 PMC 바로가기
Serological Response and Clinical Protection of Anti-SARS-CoV-2 Vaccination and the Role of Immunosuppressive Drugs in a Cohort of Kidney Transplant PatientsArticle Published on 2022-09-022022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] administration antibody antibody response rate Antibody titer Breakthrough infection clinical Cohort conducted COVID-19 COVID-19 vaccination dose drug enrolled evaluate evaluated first dose IgG Immunosuppression immunosuppressive Immunosuppressive treatment incidence kidney transplant kidney transplant recipient lowest mRNA vaccine Patient positive Prevent protection Protective rate of seroconversion recipient recipients regimen regimens reported response retrospective cohort study role SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 second dose serological serological response significantly Solid solid organ transplant study period Transplant vaccination Vaccine vaccine dose Vaccines [DOI] 10.3390/v14091951 PMC 바로가기
Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages고도로 제한된 SARS-CoV-2 수용체 발현 및 1차 인간 단핵구 및 단핵구 유래 대식세포에 의한 감염에 대한 내성Article Published on 2022-09-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cause caused cellular cellular receptor condition contribute coronavirus COVID-19 Defense direct infection enzyme Express expression facilitated global pandemic immune activation in vitro Infection involved Macrophage macrophages MDM mechanism monocyte monocyte-derived macrophage Monocyte-derived macrophages Monocytes myeloid cell myeloid cells occur Pathogenesis primary human monocyte priming pseudotyped virions receptor remained resistance to infection SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV2 SARS-CoV2 infection Severe acute respiratory syndrome severity spike subtype the disease TMPRSS2 unlikely unpolarized viral spike [DOI] 10.1002/JLB.4COVA1121-579RR PMC 바로가기 [Article Type] Article
Biomarkers selection for population normalization in SARS-CoV-2 wastewater-based epidemiologyArticle Published on 2022-09-012022-11-15 Journal: Water research [Category] SARS, 바이오마커, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome addition approach Biomarker Biomarkers CDC changes in city Community complement Concentration contributing to coronavirus coronavirus disease correlation COVID-19 creatinine Critical demonstrated Dilution distribution epidemiological Epidemiology evaluated FIVE help high accuracy investigated Local metabolite Mild normalized outbreak Paraxanthine plant Population Population biomarker Population normalization Prevalence reported SARS-CoV-2 SARS-CoV2 selected significantly tested the SARS-CoV-2 Treatment utility Variability Viral load viral loads virus Volume Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118985 PMC 바로가기
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] accompanied ACE2 Affect affected Alter antiviral activity Beta Beta-cyclodextrin Calu Calu-3 Cell cell line cell lines cholesterol COVID-19 COVID-19 disease cyclodextrin Cytokines cytopathic effects demonstrated disease drug Drug repurposing evidenced excipient experimental models expression Human Hyperinflammatory syndrome immunomodulatory effect in vitro in vivo Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibiting investigated microbial products mitigate Monocytes Particles pathophysiology primary human cells Proinflammatory cytokine proinflammatory cytokines protein levels reducing reduction in Replication replication complexes required Respiratory system safety profile SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 selected selective significantly systemic manifestations the disease therapeutic therapeutic agent therapeutic strategy These data treating Treatment viral cytopathic effect virus virus replication virus RNA [DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
Follow-up evaluation of patients with liver test abnormalities detected during SARS-CoV2 infectionSARS-CoV2 감염 중 간검사 이상 소견이 발견된 환자에 대한 추적조사Observational Study Published on 2022-09-012022-09-11 Journal: Journal of viral hepatitis [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Abnormalities abnormality Admission antibiotic Blood blood test coronavirus disease Coronavirus disease-19 COVID-19 criteria defined discharge disease during admission evaluated Evolution Factor Fatty liver fatty liver disease ferritin Follow-up Gender immunomodulatory individuals Infection inspired oxygen fraction liver Liver Biopsy Liver function Liver function test liver function tests male metabolic-associated fatty liver disease (MAFLD). Most patient Most patients no correlation Non-invasive observational study outcome oxygen P/F partial pressure Partial pressure of oxygen Patient patients persistent Retrospective analysis SARS-CoV2 SARS-CoV2 infection severity Treatment variable was performed [DOI] 10.1111/jvh.13718 PMC 바로가기 [Article Type] Observational Study