Abnormal Liver Function Tests Were Associated With Adverse Clinical Outcomes: An Observational Cohort Study of 2,912 Patients With COVID-19Medicine Published on 2021-06-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95%CI abnormality adjusted Admission Adverse adverse outcomes alanine aminotransferase albumin alkaline phosphatase ALP ALT Aspartate aminotransferase association AST baseline China clinical Clinical outcome collected data confounders consecutive patient coronavirus disease coronavirus disease-2019 COVID-19 Cox regression models died function homogeneous hospital Hospitalization hospitalized patient ICU ICU admission increased risk Infection intensive care large cohort Liver function liver function test abnormality mechanical ventilation median Mortality outcome outcomes parameter Patient patients required severe acute respiratory syndrome coronavirus 2 severity of COVID-19 significantly Test total bilirubin was measured with COVID-19 [DOI] 10.3389/fmed.2021.639855 PMC 바로가기 [Article Type] Medicine
Gender Specific Differences in Disease Susceptibility: The Role of EpigeneticsReview Published on 2021-06-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adverse effect adverse outcomes Autoimmune disease Autoimmune diseases Cancer cellular comparable complex complex diseases COVID-19 difference Diseases Effects Epidemiological study Epigenetic epigenetics escape genes examined explain female females Gender Gender bias Hypothesis immune response immune responses immune system inactivation increasingly Infection Infectious diseases majority male males mechanism miRNA morbidity neurodegenerative outcome Pathogens reported respond role SARS-COV-2 infection Sex skewed skewed X inactivation Specific susceptibility the SARS-CoV-2 vaccination vaccination outcomes women X chromosome xenobiotics [DOI] 10.3390/biomedicines9060652 PMC 바로가기 [Article Type] Review
Resilience and vulnerability of maternity services in Zimbabwe: a comparative analysis of the effect of Covid-19 and lockdown control measures on maternal and perinatal outcomes, a single-centre cross-sectional study at Mpilo Central HospitalObservational Study Published on 2021-06-042022-10-04 Journal: BMC Pregnancy and Childbirth [Category] MERS, SARS, 임상, [키워드] Admission adverse outcomes Analysis Antenatal Caesarean section Care changed clinics COVID-19 cross-sectional cross-sectional design death estimate expected Government Healthcare systems hospital Impact increase in Indirect maternal outcomes Indirect perinatal outcomes Local lockdown Maternal measure morbidity morbidity and mortality Mortality Neonatal outcome outcomes pandemic reduced Regulation Resilience resource Result retrospective rupture statistically significant Stillbirth the mean uterine vulnerability women Zimbabwe [DOI] 10.1186/s12884-021-03884-5 PMC 바로가기 [Article Type] Observational Study
Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 InfectionArticle Published on 2021-06-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Adverse adverse outcome adverse outcomes age age and gender analysed association Care CFS clinical COVID-19 death Department Diagnosis Emergency emergency department enrolled First wave frailty Gender hospital intensive care Mortality nasopharyngeal Older outcome pandemic Patient patients with COVID-19 predictor presenting prospective cohort study SARS-CoV-2 SARS-CoV-2 PCR scale Suspected Swab tested the median was performed women [DOI] 10.3390/jcm10112472 PMC 바로가기 [Article Type] Article
Extubation Failure in Critically Ill COVID-19 Patients: Risk Factors and Impact on In-Hospital MortalityOriginal Research Published on 2021-06-022022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval adverse outcomes age Analysis anticoagulation clinical factor cohort study competing Corticosteroids COVID-19 COVID-19 patient COVID-19 patients Critical illness Critically ill death extubation Factor Factors failure greater hazard ratio hospitalized COVID-19 patients identify Ill Impact implication male material Mortality multivariate nasal Non-pulmonary Novel coronavirus occurred Organ failure Patient PEEP predict predicted prognostic prone reintubation Remdesivir renal required Respiratory Support risk Tocilizumab Vasopressor Ventilation [DOI] 10.1177/08850666211020281 PMC 바로가기 [Article Type] Original Research
Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study영국의 6·900만 인구의 체질량 지수와 COVID-19 심각도 사이의 연관성: 전향적, 지역사회 기반, 코호트 연구Articles Published on 2021-06-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 진단, [키워드] adjusted adjusted hazard ratio Admission adverse outcome adverse outcomes age association available data behavioural black black people BMI body-mass cardiovascular disease Characteristics cohort study Comorbidities conditions COVID-19 COVID-19 severity Cox proportional hazard models database death demographic characteristics diabetes died Diseases eligible England Ethnicity Factors finding for inclusion funding Health hospital Hospital admission hypertension ICU ICU admission increase in individual Infection infection with SARS-CoV-2 intensive care intensive care unit Interaction linear morbidities nadir NIHR notable obesity office Older Oxford Patient positive Positive test Public Health England QResearch recorded Registered Relative risk risk risk factor SARS-CoV-2 SARS-CoV-2 test severe COVID-19 significant interaction Statistics type 2 diabetes White people younger people [DOI] 10.1016/S2213-8587(21)00089-9 PMC 바로가기 [Article Type] Articles
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected PatientsSARS-CoV-2와 인플루엔자 바이러스 감염 환자 간의 전사 서명 차이Observational Study Published on 2021-05-312022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 임상, [키워드] adverse outcome adverse outcomes B cell blood cell Blood cells Cell cell cycle Complete Complication COVID-19 COVID-19 pathogenesis COVID-19 severity degranulation develop difference distress dramatic increase dysregulated dysregulation dysregulation of T cells Evidence feature gene expression pattern group healthy host response IFN immune profiling immune signature Immunoglobulin Increasing individuals individuals with COVID-19 infected individuals infected with SARS-CoV-2 Influenza influenza viruses involved life-threatening metabolism Neutrophils NK cells over-expression Patient provided reason reduction respiratory distress responses RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severity signature Symptom T cells Toxicity transcriptomic transcriptomic profile transcriptomic profiles website whole blood transcriptome [DOI] 10.3389/fimmu.2021.666163 PMC 바로가기 [Article Type] Observational Study
Modern Technologies in the Rehabilitation of Patients with Multiple Sclerosis and Their Potential Application in Times of COVID-19Review Published on 2021-05-302022-10-30 Journal: Medicina [Category] Coronavirus, SARS, [키워드] adverse outcomes All participant application Cognitive function conducted COVID-19 COVID-19 pandemic criteria diagnosed effective Effectiveness FIVE healthcare IMPROVE inaccessible Intervention involved Kinect less maintain mandatory Material and Method measure Multiple multiple sclerosis objective occupational therapy participant Patient patients physical Physiotherapy Potential rehabilitation remote reported required Result SARS-CoV2 sclerosis Seven social distancing systematic review technology tele-exercises telerehabilitation time virtual reality Web of Science were used Xbox [DOI] 10.3390/medicina57060549 PMC 바로가기 [Article Type] Review
The Role of Neuropsychological Factors in Perceived Threat of SARS-CoV-2 in Healthy AgeingArticle Published on 2021-05-292022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] addressed adverse outcomes Ageing Anxiety anxiety symptom baseline cognitive functions Contagion COVID-19 pandemic Factor frailty healthy highest highlight information joint lockdown mood deflections normal aging Older older population pandemic Perceived perceived threat phenotypic frailty model physical predicted preserved required resource risk role SARS-CoV-2 Support threat while [DOI] 10.3390/ijerph18115847 PMC 바로가기 [Article Type] Article
Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendationsFeature Published on 2021-05-242022-10-04 Journal: Bone marrow transplantation [Category] SARS, 임상, [키워드] adverse outcomes age Area Autoimmune disease caused Clinicians co-morbidity coronavirus 2 COVID-19 COVID-19 pandemic Evidence globe group Hematopoietic stem cell HSCT Immunosuppressive treatment Immunotherapy Increasing indications Infectious diseases Inflammatory bowel disease international organization Local Modification Mortality National neurological Neurological disorders pandemic Patient Patient care pediatric populations predicted public health recommendation reported Research question respiratory Rheumatic diseases rheumatological risk risk factor SARS-CoV-2 severe disease Stem cell transplantation Support unmet need [DOI] 10.1038/s41409-021-01326-6 PMC 바로가기 [Article Type] Feature