Germinal Center-Induced Immunity Is Correlated With Protection Against SARS-CoV-2 Reinfection But Not Lung Damage생식기 센터 유도 면역은 SARS-CoV-2 재감염에 대한 보호와 상관관계가 있지만 폐 손상은 아닙니다Article Published on 2021-12-012022-09-12 Journal: The Journal of Infectious Diseases [Category] 진단, [키워드] acute respiratory syndrome Against alleviate antibody-secreting cell clade Combination coronavirus coronavirus disease COVID-19 damage Diagnosis Diffuse alveolar damage elicit gcs Germinal Germinal center highlight humans immune responses IMPROVE Infection lung lung damage macaque macaques memory B cells pathogen invasion protection protective humoral immunity protective immunity reduction in Reinfection replicating virus respiratory tract resulting SARS-CoV-2 SARS-COV-2 infection Seroconversion subsequent infections tissue Treatment vaccination Vaccine development Viral load viral reinfection. virus [DOI] 10.1093/infdis/jiab535 PMC 바로가기 [Article Type] Article
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 DiseaseSARS-CoV-2 감염 및 COVID-19 질병에서 노화 및 노화의 역할Review Published on 2021-11-302022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aging alleviate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 severity current determinant determinants driven by dysregulated immune response ENhance focus global pandemic highlight Highlights Hyperinflammatory immune system immunosenescence indicate interconnection long-COVID morbidity and mortality Mortality pathway Prevent reduce mortality Research respiratory risk role SARS-CoV-2 SARS-COV-2 infection sendotypes senescence senescent senescent cells senolytics severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Severe infection severity Symptoms therapeutic intervention therapeutic option vaccination [DOI] 10.3390/cells10123367 PMC 바로가기 [Article Type] Review
Pathogenesis and Treatment of Cytokine Storm Induced by Infectious DiseasesReview Published on 2021-11-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activated alleviate caused Cell characterized circulating cytokine clearance cytokine Cytokine storm described disease Diseases effective elevated facilitate Host immune system induced Infection Infectious disease Inflammation invading pathogens invasive occur pathogen pathogenic pathophysiological mechanism profile progression released storm Strategy therapeutic strategy therapy tissue damage Treatment Treatment strategies variety [DOI] 10.3390/ijms222313009 PMC 바로가기 [Article Type] Review
Protocol: Benefits and harms of remdesivir for COVID-19 in adults: A systematic review with meta-analysisStudy Protocol Published on 2021-11-292022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] adverse events all-cause mortality alleviate analyses approach available data benefit Bia Care Clinical data Clinical guidelines clinician Contact COVID-19 death decrease drug treatment eligible Evidence finding Health health care systems help Hospital stay include indication information less Meta-analysis morbidity and mortality Patient Placebo Primary outcome random-effect Randomised trial Regulatory regulatory agencies Remdesivir resources risk of bia searched secondary outcome selective Serious Adverse Events severe disease Severity of disease shown Sponsor Standard of care systematic review Treatment Trial trials website [DOI] 10.1371/journal.pone.0260544 PMC 바로가기 [Article Type] Study Protocol
Quality of life and mental health of children with rare congenital surgical diseases and their parents during the COVID-19 pandemicResearch Published on 2021-11-272022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] Coronavirus, MERS, SARS, [키워드] affected alleviate approach children conducted control group COVID-19 COVID-19 pandemic disease evaluate groups health-related quality of life impairment influence investigated lockdown Measures mental health outcome parent parents pediatric Pediatric surgery presenting Quality Quality of life questionnaire rare disease rare diseases receive regression analysis Result risk factor significantly higher significantly lower supplementary material supportive care surgical university hospital was collected [DOI] 10.1186/s13023-021-02129-0 PMC 바로가기 [Article Type] Research
Social deprivation as a risk factor for COVID-19 mortality among women and men in the UK Biobank: nature of risk and context suggests that social interventions are essential to mitigate the effects of future pandemicsOriginal Research Published on 2021-11-272022-10-29 Journal: Journal of epidemiology and community health [Category] Coronavirus, MERS, SARS, [키워드] 95% CI Adjustment age alleviate association associations baseline cardiovascular disease cause continuous scale COVD-19 COVID-19 COVID-19 mortality death Deprivation died Effect Effects Evidence Factor fatal influenza greater incidence Infection Intervention lack magnitude men mitigate Mortality National objective other diseases outcome measure Pandemics participant person years Pneumonia Prospective quantified Result resulting risk risk factor score setting Sex difference social class social deprivation UK biobank women [DOI] 10.1136/jech-2020-215810 PMC 바로가기 [Article Type] Original Research
Validation of a COVID-19 self-assessment tool for the prediction of COVID-19 in a primary health care setting in EgyptResearch Article Published on 2021-11-252022-10-28 Journal: Primary Health Care Research & Development [Category] COVID-19, MERS, SARS, [키워드] 95% CI Accuracy Alexandria alleviate Analysis calculated Care comparable Contact COVID-19 Egypt enrolled Epidemic evaluated globe Guidance Health healthcare professionals implementation IMPROVE increased the risk infected patient Infection initial introduced management media Ministry of Health Negative predictive value offer parameters Patient PCR polymerase chain Population Positive predictive value Predictive predictor presenting Primary Health Care recent released reliability remote reporting symptom respiratory infection SARS-CoV-2 SARS-COV-2 infection self-assessment sensitivity specificity Symptom tested the disease the epidemic Travel Triage validation Validity [DOI] 10.1017/S1463423621000736 PMC 바로가기 [Article Type] Research Article
Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs중증 COVID-19 질환 환자의 폐에서 세포내 보체의 활성화는 폐의 T-세포 활성을 감소시킵니다Immunology Published on 2021-11-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation activity acute respiratory syndrome coronavirus alleviate Asymptomatic bioinformatics cellular and molecular Cellular and molecular mechanisms classical complement Complement activation conducted coronavirus coronavirus 2 COVID-19 COVID-19 patients decrease disease pathology disease severity downregulation Effect examined help Ingenuity Pathway Analysis Intracellular knowledge lung lung cell lung cells Lung pathology Lungs mechanical ventilator mechanism modulation multi-organ failure Novel coronavirus potential mechanisms proinflammatory reduce respiratory respiratory distress responsible RNA sequencing data SARS-CoV-2 SARS-COV-2 infection sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease severe COVID-19 patients Severe respiratory distress Support survival T-cell T-cells Treatment upregulation [DOI] 10.3389/fimmu.2021.700705 PMC 바로가기 [Article Type] Immunology
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injuryACE2-유사 카르복시펩티다제 B38-CAP는 SARS-CoV-2로 유발된 폐 손상으로부터 보호합니다Article Published on 2021-11-232022-09-12 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression acting acute lung injury alleviate angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models carboxypeptidase cardiovascular disease cell entry COVID-19 patients decoy degrade downregulate downregulated edema Elevation endogenous enzymatic activity enzyme Evidence human ACE2 IMPROVE in vivo Infection inhibit inhibit SARS-CoV-2 lung lung edema Lung injury Lung pathology Lungs not neutralize Pathologies pathology peptides PROTECT Protective Protein receptor recombinant Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters significantly soluble ACE2 spike Symptom therapeutic strategy transgenic mice Treatment virus [DOI] 10.1038/s41467-021-27097-8 PMC 바로가기 [Article Type] Article
Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gutArticle Published on 2021-11-182022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] addition administration age alleviate appear association Bacterial bacterial microbiome benefit children Cluster Cohort collected Community disorder disrupting enrolled eukaryotic evaluate exacerbated fungal fungi global effort Gut gut microbiota Health Intervention Malnutrition Microbiome Micronutrient micronutrients outcomes Parasitology promote Protozoa Randomized controlled trial reduced risk Stool subset Vitamin vitamins [DOI] 10.1038/s41467-021-27010-3 PMC 바로가기 [Article Type] Article