Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of VirusesArticle Published on 2021-09-172022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adenovirus Analysis Antiviral Antiviral effect conformational change coronavirus decrease enhanced function heparin herpes simplex HSV-1 immortalized infected cell investigated Magnesium magnesium chloride modified heparin NMR nuclear magnetic resonance previous study primary cells Replication reported SARS-CoV-2 significantly Spectrum supernatant tested Viral load virus virus growth [DOI] 10.3390/ijms221810075 PMC 바로가기 [Article Type] Article
Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro일본 발효 대두 음식 인 Natto 추출물은 시험 관내 SARS-COV-2를 포함한 바이러스 감염을 직접 억제합니다.Article Published on 2021-09-172022-08-31 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Antiviral effect Bacillus Bacillus subtilis BHV-1 binding bovine caused Cell cells coronavirus domain Evidence examined glycoprotein Glycoprotein D Health heat inactivation impair in vitro incubated infect Infection inhibit inhibited Japanese N501Y Natto nutritious Point mutation protease proteolysis RBD RBD protein Receptor binding domain respiratory restored SARS-CoV-2 Serine serine protease inhibitor severe acute respiratory syndrome Coronavirus shown the cells treated variant Viral viral infection Viral proteins viruses western blot Western blot analysis [DOI] 10.1016/j.bbrc.2021.07.034 PMC 바로가기 [Article Type] Article
MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral ActivityResearch Article Published on 2021-09-142022-10-29 Journal: mBio [Category] COVID-19, [키워드] activity acute respiratory syndrome Antiviral antiviral activity Antiviral effect antiviral response caused cell lines cellular cellular RNA changes in complexes conserved coronavirus CoVs CRISPR-Ca cytoplasmic decrease described Helicase help highly pathogenic highly pathogenic coronavirus highly pathogenic CoVs human CoV human CoVs humans identify immunoprecipitation in viral indicated Infection Interaction involved life-threatening MERS-CoV MERS-CoV infection metabolism Middle East modulation MOV10 mutant N protein nucleocapsid nucleocapsid protein overexpression pathogen Pathogenesis Protein required Respiratory disease respiratory syndrome coronavirus RNA SARS-CoV-2 significantly increased Structure therapeutic targets understanding Viral RNA viral RNAs virus titer Virus-host interactions viruses wild-type [DOI] 10.1128/mBio.01316-21 PMC 바로가기 [Article Type] Research Article
Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL ProteaseArticle Published on 2021-09-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] α-CoV 3CL 3CL Protease 3CLpro alphacoronavirus antiviral activity Antiviral effect binding binding pocket cause conserved Coronaviral docking energy transfer epidemic diarrhea evaluated gastroenteritis high mortality Hypericin infections inhibit inhibitory effect molecular docking mutants PEDV reduced resulting SARS-CoV-2 sequence shown significantly targeting TGEV viral replication virus viruses [DOI] 10.3390/v13091825 PMC 바로가기 [Article Type] Article
Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?Medicine Published on 2021-09-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acting Angiotensin converting enzyme-2 anti-inflammatory effect anti-SARS-CoV-2 antiviral activity Antiviral effect attrition rates clinical trial complex Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients creating cyclophilin cyclosporin cyclosporin A death Deleterious drug Drug discovery Health highlight incidence increasingly investigated management molecular mechanism performed proinflammatory cytokines reducing Safe SARS-CoV-2 shown target therapeutic Therapeutic strategies therapy thrombosis tissue damage viral RNA synthesis [DOI] 10.3389/fmed.2021.663708 PMC 바로가기 [Article Type] Medicine
Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In VitroArticle Published on 2021-09-032022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activated activating ADK analyzed Antiviral antiviral activity antiviral drug Antiviral effect Antiviral treatment approach Calu-3 cell circulating SARS-CoV-2 variant combination therapy combined treatment Culture drug interaction Drug repurposing Effect Enzymes expressed Fluoxetine GS-441524 in vitro kinase metabolite nucleoside nucleoside GS-441524 offer patients with COVID-19 plasma Remdesivir reported Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 pandemic synergistic synergy Therapeutic treatment tissues Treatment [DOI] 10.3390/pharmaceutics13091400 PMC 바로가기 [Article Type] Article
Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitorSARS-CoV-2 주요 프로테아제 억제제로서 Withania somnifera (Ashwagandha)의 생리 활성 분자 식별Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] active site antimalarial drug Antimalarial drugs Antiviral effect approach Ashwagandha binding affinity binding free energy causative agent clinical trials Compound compounds COVID-19 COVID-2019 develop disease Diseases docking docking study drug Drug discovery evaluate exhibited free energy Health Organization highest hydrogen hydrogen-bonding interaction hydrogen-bonding interactions identification indicate inhibitor M pro MD simulation molecular docking nCoV pandemic disease polyprotein polyproteins Practitioner predict protease Protein Replication required SARS-CoV-2 SARS-CoV-2 main protease Scientific community selected stability triggered Vaccine virus Withania somnifera World Health Organization [DOI] 10.1080/07391102.2020.1790425 PMC 바로가기 [Article Type] Article
Convergent evidence for the antiviral effects of several FDA-approved phenothiazine antipsychotics against SARS-CoV-2 and other coronavirusesSARS-CoV-2 및 기타 코로나바이러스에 대한 여러 FDA 승인 페노티아진 항정신병제의 항바이러스 효과에 대한 수렴적 증거Editorial Published on 2021-09-012022-09-11 Journal: Revista brasileira de psiquiatria (São Paulo, Bra [Category] SARS, 치료제, [키워드] Antiviral effect Evidence other coronavirus SARS-CoV-2 [DOI] 10.1590/1516-4446-2020-0024 PMC 바로가기 [Article Type] Editorial
A randomised controlled trial of effectiveness and safety of Niclosamide as add on therapy to the standard of care measures in COVID-19 managementResearch article Published on 2021-09-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 신약개발, 임상, 치료제, [키워드] adjusted age anti-parasitic drug Antiviral Antiviral effect antiviral medicine Care caused clinical benefit clinical trial Comorbidities Comorbidity Control control group COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cured death Diabetes Mellitus drug Effectiveness Endpoint experimental group Gender hospital incidence increased the risk less male management measure Niclosamaide niclosamide Older open label pandemic Patient per day randomised controlled trial reduced Result risk SARS-CoV-2 SARS-CoV2 Side effect significant difference significantly Standard of care study group survival therapeutic effect therapy Time to recovery took place treat treated Treatment viral infections [DOI] 10.1016/j.amsu.2021.102779 [Article Type] Research article
A five-day course of ivermectin may reduce the duration of COVID-19 illness이버멕틴의 5일 과정은 COVID-19 질병의 기간을 줄일 수 있습니다Comment Published on 2021-09-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] Abstract Antiviral Antiviral effect Course COVID-19 COVID-19 illness Ivermectin reduce [DOI] 10.1016/j.ijid.2021.07.050 PMC 바로가기 [Article Type] Comment