antiviral immunity – Page 12 – Communicable Diseases Research

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Report

Published on 2020-08-072022-10-06
Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단,

[키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA
[DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report

Systemic immunosuppression in times of COVID-19: Do we need to rethink our standards?

COVID-19 시대의 전신 면역 억제: 우리의 기준을 재고해야 합니까?

Review

Published on 2020-08-012022-09-11
Journal: Journal der Deutschen Dermatologischen Gesellschaf [Category] 치료제,

Repurposing CD8 + T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?

암 면역 요법을 위한 SARS-CoV-2에 대한 CD8 + T 세포 면역의 용도 변경: COVID-19 대유행의 긍정적인 측면?

Review

Published on 2020-07-162022-09-12
Journal: Oncoimmunology [Category] SARS, 진단,

COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment

Review

Published on 2020-06-242022-10-30
Journal: Journal of Fungi [Category] COVID-19,

[키워드] Activation acute respiratory distress antiviral immunity ARDS aspergillosis Aspergillus Autopsy Bronchoalveolar lavage fluid caused challenges clinical development Co-infection contribute Coronavirus disease-19 COVID-19 COVID-19 patient Culture danger-associated molecular pattern diagnostic test disease disease transmission drug drug–drug interaction Effect epithelial European Confederation of Medical Mycology Expert statement favor fungal Host ICU immune response Inflammatory inflammatory disease Influenza Like Novel coronavirus Pathogenesis pathway Patient performed pharmacokinetic Prevalence profiles pulmonary renal required resulting risk risk factor Risk factors SARS CoV-2 SARS-CoV-2 severe COVID-19 superinfection syndrome Treatment urgency
[DOI] 10.3390/jof6020091 PMC 바로가기 [Article Type] Review

Biological sex impacts COVID-19 outcomes

생물학적 성은 COVID-19 결과에 영향을 미칩니다

Opinion

Published on 2020-06-222022-08-13
Journal: PLoS Pathogens [Category] Biology and Life Sciences, COVID-19,

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

Research Article

Published on 2020-06-192023-06-08
Journal: Protein & Cell [Category] Fulltext, 신종인플루엔자,

[키워드] antiviral immunity influenza A virus PB2 TRAF3 TRIM35 ubiquitination
[DOI] 10.1007/s13238-020-00734-6 PMC 바로가기 [Article Type] Research Article

Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells

Immunology

Published on 2020-06-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 A-a gradient acute lung injury acute respiratory distress addition allergic reaction alveolar macrophage alveolar pressure antiviral immunity Antwerp ARDS Belgium blinded Breastfeeding Bruges carbonate clinical clinician Confirmed COVID-19 infection control group Controlled trial COVID-19 COVID-19 pandemic defined Delta dissemination Effect element enrolled enrolment EudraCT ferritin level Ghent GM-CSF granulocyte-macrophage colony-stimulating factor High dose hospital Hypothesis hypoxic failure hypoxic respiratory failure Immune homeostasis inflammatory monocyte Inhaled Intervention intravenous invasive mechanical IWRS system leukine® lung malignancy mechanical ventilation mechanical ventilator Methylprednisolone number objective Open-label outcome oxygen Oxygenation paO2/fiO2 parameters Partial participant Participants Patient PF ratio pregnant primary endpoint progression of disease promote Protein protocol randomised randomised controlled trial randomization Randomized reached receive recruitment Registered Repair mechanisms replaced Respiratory failure Roeselare Sample size sargramostim SpO2 standard care Standard of care status Study protocol supplemental oxygen Support syndrome therapy treat Treatment Trial university ventilatory support Version website were excluded White blood cell
[DOI] 10.1186/s13063-020-04451-7 PMC 바로가기 [Article Type] Letter

Main Clinical Features of COVID-19 and Potential Prognostic and Therapeutic Value of the Microbiota in SARS-CoV-2 Infections

Microbiology

Published on 2020-06-052022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] ACE2 acute respiratory distress acute respiratory syndrome Analysis angiotensin-converting enzyme 2 antiviral immunity association Bacteria caused change changes in clinical clinical feature Clinical features coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 patients determine Diagnosis digestive tract distribution ENhance Fatality rate gut microbiota help host cells identity immune cells immunopathology infect infecting interferon intestinal tract intestine lung microbial microbiota much lower nucleotide sequence outcome outcomes pandemic Patient peptides Potential predict receptor regulate respiratory virus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SCFAs secretion syndrome Therapies Treatment turn value
[DOI] 10.3389/fmicb.2020.01302 PMC 바로가기 [Article Type] Microbiology

Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA Position paper of the German ARIA Group in cooperation with the Austrian ARIA Group , the Swiss ARIA Group , German Society for Applied Allergology (AEDA) , German Society for Allergology and Clinical Immunology (DGAKI) , Society for Pediatric Allergology (GPA) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC and the European Academy of Allergy and Clinical Immunology (EAACI)

Research Article

Published on 2020-05-282022-10-28
Journal: Allergologie Select [Category] COVID-19,

[키워드] Abstract Academy allergen allergen immunotherapy allergology antiviral immunity clinical COVID-19 European group Immunotherapy Medicine position SCIT SLIT Society
[DOI] 10.5414/ALX02147E PMC 바로가기 [Article Type] Research Article