Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trialRandomized Controlled Trial Published on 2022-01-012022-10-04 Journal: Intensive care medicine [Category] Fulltext, SARS, 임상, [키워드] adjusted analysed analyses Bayesian Bayesian analysis Bayesian model benefit blinded clinically conducted coronavirus disease Corticosteroids COVID COVID-19 CrI Critical illness days alive Dexamethasone effect size facilitate hospital hypoxaemia intention-to-treat population International Interpretation interval mean difference median Mortality outcome Patient patients patients with COVID-19 posterior probability Primary outcome Probability randomised reached Result risk Sensitivity analyses serious adverse reaction statistical significance Support threshold Trial [DOI] 10.1007/s00134-021-06573-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Excessive Worrying as a Central Feature of Anxiety during the First COVID-19 Lockdown-Phase in Belgium: Insights from a Network ApproachResearch Article Published on 2021-12-302022-10-28 Journal: Psychologica Belgica [Category] COVID-19, [키워드] alleviate Anxiety anxiety symptom approach association Bayesian collected computational method consequence COVID-19 COVID-19 pandemic data-driven determine Directed acyclic graph feature Features GAD Gaussian Graphical Model impacted insight Interaction lockdown mental health network Network Approach to Psychopathology Novel coronavirus offer pandemic problems Psychopathology public health reported SARS-CoV-2 significantly Symptoms the WHO variables Worry [DOI] 10.5334/pb.1069 PMC 바로가기 [Article Type] Research Article
Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study초기 SARS-COV-2 환자에서 Molnupiravir의 최적 용량 및 안전성 : A 상 I, 오픈 라벨, 용량-에스calating, 무작위 대조 연구Randomized Controlled Trial Published on 2021-12-272022-08-13 Journal: Journal of Antimicrobial Chemotherapy [Category] MERS, SARS, 임상, [키워드] adaptive adult outpatients adverse event Bayesian Clinical research Control controls COVID-19 treatments dose enrolled evaluated facility greater group Mild molnupiravir objective Open-label optimal dose outcome Outpatient participant Patient PCR-confirmed pharmacokinetics phase platform Primary outcome Probability progression Randomized randomized controlled study randomized-controlled receiving responses Result Safe SARS-COV-2 infection screened secondary Secondary outcomes severe adverse events Standard-of-care symptom onset symptomatic infection Toxicity Trial Virological [DOI] 10.1093/jac/dkab318 PMC 바로가기 [Article Type] Randomized Controlled Trial
Exploration of SARS-CoV-2 3CL pro Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay가상 스크리닝 방법, FRET 감지 및 CPE 분석에 의한 SARS-CoV-2 3CL pro 억제제 탐색Article Published on 2021-12-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료기술, 치료제, [키워드] 3CL pro Algorithm Analysis Antiviral effect Bayesian binding mechanism biological activity caused CDOCKER component Compound compounds coronavirus COVID-19 CPE cross Cytopathic effect database detection determined by drugs eight energy transfer exploration half-maximal inhibitory concentration indicated information inhibiting inhibitor machine learning algorithm Machine learning algorithms machine learning model molecular naïve Novel coronavirus predicted protease Replication SARS-CoV-2 Screening scutellarein selected trihydroxyflavone two-dimensional was determined [DOI] 10.1021/acs.jcim.1c01089 PMC 바로가기 [Article Type] Article
Subjective Well-Being among Parents of Children with Special Educational Needs in Hong Kong: Impacts of Stigmatized Identity and Discrimination under Social Unrest and COVID-19Article Published on 2021-12-262022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] association Bayesian carried children COVID-19 COVID-19 pandemic cross-sectional survey demonstrated disadvantaged groups discrimination distress event events group higher risk Hong Kong identity Impact mental health mental health condition mental health problems negative emotions parent parents reported Satisfaction SEN social unrest stressors Subjective unique Unrest variables [DOI] 10.3390/ijerph19010238 PMC 바로가기 [Article Type] Article
Efficacy and safety of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis caused by novel coronavirus disease A protocol for Bayesian network meta-analysis새로운 코로나 바이러스 질병으로 인한 폐 섬유증에서 현대 의학과 한약의 조합의 효능 및 안전성 베이지안 네트워크 메타 분석을위한 프로토콜6700 Published on 2021-12-232022-08-31 Journal: Medicine [Category] meta-analysis, 임상, 치료제, [키워드] Analysis Bayesian caused Chinese choice clinical Clinical significance Clinical studies Clinical treatment collaboration Combination coronavirus coronavirus disease COVID-19 Data processing database deficiency develop discharge drug Effectiveness Efficacy and safety eligibility criteria English evaluate Evidence fibrosis Health hierarchy hospital Inflammation Inflammatory Lung fibrosis medication Meta-analysis modern medicine Network meta-analysis New New coronavirus NMA novel Novel coronavirus novel coronavirus disease Patient positive protocol pulmonary fibrosis pulmonary inflammation Randomized controlled trial ranking recommendation registration number Research screened Stata Support TCM Traditional Chinese medicine Treatment treatment methods various treatment various treatments was used [DOI] 10.1097/MD.0000000000028282 PMC 바로가기 [Article Type] 6700
Solutions to problems of nonexistence of parameter estimates and sparse data bias in Poisson regressionOriginal Research Articles Published on 2021-12-212022-10-28 Journal: Statistical Methods in Medical Research [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] approach arising Bayesian coefficient coefficients Count data COVID-19 data set dataset estimate evaluated example Firth’s penalization generalized linear models include likelihood Modification outbreak parameter penalized regression Poisson regression problem provide reduction separation solution variety while [DOI] 10.1177/09622802211065405 PMC 바로가기 [Article Type] Original Research Articles
Bayesian spatio-temporal distributed lag modeling for delayed climatic effects on sparse malaria incidence data희박한 말라리아 발병률 데이터에 대한 지연된 기후 영향에 대한 베이지안 시공간 분산 지연 모델링Research Published on 2021-12-202024-07-27 Journal: BMC Medical Research Methodology [Category] 말라리아, [키워드] Bayesian lag effect malaria spatiotemporal weather [DOI] 10.1186/s12874-021-01480-x PMC 바로가기 [Article Type] Research
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcomeCOVID-19 환자 혈청의 비표적 대사체학은 심각성과 결과 모두의 잠재적인 예후 마커를 나타냅니다Original Article Published on 2021-12-202022-09-10 Journal: Metabolomics [Category] SARS, 바이오마커, 치료기술, [키워드] among others Analysis approach Bayesian Bayesian logistic regression model blind capture Cohort COVID-19 COVID-19 patient COVID-19 patient serum cross Deceased deoxycytidine diagnosis of COVID-19 discharged energy metabolism high resolution Hospital admission Host host inflammatory response host response include infected individual infected individuals Infection Kynurenine LC–MS/MS Orbitrap logistic regression model marker metabolism metabolite metabolites metabolomics Mild nucleic acid objective outcome Patient patient treatment Planning positive predict predicted Predictive predictor profile Prognostic marker property qualitative detection Result reveal ROC AUC ROC Curve selected serum severity statistical significance subset supplementary material Treatment UHPLC UHPLC-MS/MS uninfected control Untargeted metabolomics validation study Viral Viral load viral nucleic acid was performed [DOI] 10.1007/s11306-021-01859-3 PMC 바로가기 [Article Type] Original Article
Risk-benefit analysis of the AstraZeneca COVID-19 vaccine in Australia using a Bayesian network modelling framework베이지안 네트워크 모델링 프레임워크를 사용한 호주 AstraZeneca COVID-19 백신의 위험-편익 분석Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] Adverse adverse events age age and sex Analysis AstraZeneca Atypical AZ vaccine Bayesian Bayesian network Bayesian networks benefit blood clot Blood clots Case fatality rate CFR COVID-19 COVID-19 vaccine death doses Effectiveness estimate Evidence example Fatality rate first dose Government group groups incidence International knowledge Local Model Other outcomes outcome portal Portal vein portal vein thrombosis portal vein thrombosis) prevented Probability reported Risk-benefit analysis SARS-CoV-2 SARS-CoV-2 variant severe disease Sex significantly Sinus thrombosis thrombocytopenia thrombosis Thrombosis/thrombocytopenia syndrome Transmission vaccination Vaccine vaccine doses Vaccines Variation venous venous sinus was used [DOI] 10.1016/j.vaccine.2021.10.079 PMC 바로가기 [Article Type] Article