chromosome – Page 12 – Communicable Diseases Research

A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)

게놈 전체에 걸친 통합 게놈 연구는 엡스타인-바 바이러스 핵 항원 1(EBNA-1)에 대한 항체에 영향을 미치는 유전적 요인을 국소화합니다.

Research Article

Published on 2013-01-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Identification of Orch3 , a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C

자가면역 고환염에 대한 지배적인 내성을 제어하는 유전자좌인 Orch3의 확인, 키네신 계열 구성원 1C

Research Article

Published on 2012-12-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major adjuvants allele alleles animal model Antigen antigen presenting cell antigen presenting cells approach Author Autoimmune Autoimmune disease autoimmune disease susceptibility Autoimmune diseases Autoimmunity autologous characterization chromosome chromosome 11 controlling demonstrated disease disease susceptibility dominant encodes gene etiology exhibiting expression family family member Gene Genetic genetic determinant Genetic predisposition Genome histocompatibility complex identification immunization individual gene individual genes inflammatory disease Kif1c KIF21B KIF5A Kinesin leads loci locus major histocompatibility complex mapped member MHC MHC class MHC class II mice non-infectious orchitis over-expression polymorphism Polymorphisms proliferative Quantitative quantitative trait locus reduced required resistance resistant allele strain susceptibility susceptible T cell T cell responses transcriptional regulation transgenic variety
[DOI] 10.1371/journal.pgen.1003140 PMC 바로가기 [Article Type] Research Article

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

HLA 클래스 I 항원 인식 그루브와 관련된 중국 비인두암의 주요 유전적 결정인자

Research Article

Published on 2012-11-292022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele allele frequencies alleles Amino acid Analysis analyzed antigens association associations Author binding Cancer carcinoma carried China Chinese chromosome chromosome 6 class Cohort concert dependent on detect detected determinant disease driven by EBV epithelial Epstein-Barr virus examined facilitated GABBR1 Gene gene region genetic influence Genome-wide association study Groove Guangdong Guangxi GWAS HCG9 help High-resolution HLA HLA alleles HLA class I HLA class I gene HLA region HLA-A HLA-A and -B HLA-B HLA-F incidence independent Infection influences influences on Interaction involved large cohort Linkage disequilibrium malignancy molecular motif multivariate Nasopharyngeal carcinoma NPC nucleotide operative OR2H1 over peptide performed physically principal Recognition recognize Region regression analysis replicate Replication resolved risk second sequence SNP SNPs statistical study participant the major histocompatibility the strongest variant variants virus infection
[DOI] 10.1371/journal.pgen.1003103 PMC 바로가기 [Article Type] Research Article

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란

Research Article

Published on 2012-11-152022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells
[DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article

Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies

서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성

Research Article

Published on 2012-04-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation
[DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별

Research Article

Published on 2011-12-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene
[DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article

Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis Pneumonia

AIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성

Research Article

Published on 2011-10-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation
[DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

상호 작용을 위한 게놈 와이드 스크린은 총 콜레스테롤에 대한 허리 대 엉덩이 비율의 영향을 수정하는 4p15에 대한 새로운 위치를 밝힙니다.

Research Article

Published on 2011-10-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] A allele adipose Adipose tissue affected affecting allele approach association Author body composition candidate gene cardiovascular diseases CCKAR characterized cholesterol chromosome circulating Cohort collected Concentration conducted contribute dataset demonstrated described differential expression distribution Effect enrichment epidemiological European explain found functions G allele Gene Gene Expression Genetic variant genome-wide association genome-wide significant genomic Genotype genotypes global health GWA Health heritability homozygous identify individual initial Interaction Intervention joint Lipid lipid metabolism lipids loci locus Low-density lipoprotein Low-Density Lipoprotein cholesterol measure Meta-analysis metabolism modify Modifying New open PCDH7 Phenotypes population-based cohort profiles Ratio recent related Replication reported risk risk factor Risk factors Screen screened serum serum lipid Serum lipids Sex Standard deviation tissue Total Total cholesterol Triglyceride triglycerides variant variants waist waist-to-hip ratio WHR
[DOI] 10.1371/journal.pgen.1002333 PMC 바로가기 [Article Type] Research Article

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성

Research Article

Published on 2011-05-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants
[DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article

Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

Research

Published on 2009-08-242022-10-28
Journal: Virology Journal [Category] Coronavirus, MERS,

[키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA
[DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research