Nanodispersions of Polyelectrolytes Based on Humic Substances: Isolation, Physico-Chemical Characterization and Evaluation of Biological ActivityArticle Published on 2021-11-182022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activity antiviral activity approach binding Bioactivity Biological Cell Characteristics characterization complex complexes concentrations contribute coronavirus demonstrated detect Dilution dried droplet method effective EHA element fluorescent Frame heterogeneity humic and fulvic acids include increase in increasingly initial introduced Isolation lack medium molecular nanodispersion natural optical organ Particle particle size measurement Particles physico-chemical property polydispersity antiviral activity Polyelectrolyte polyelectrolytes Prevent Quality control Radiation receptor regulated Regulatory SEM shown spike glycoprotein stability Standardization submicron Taking the SARS-CoV-2 virus Vero E6 VERO-E6 virucidal virus X-ray zeta potential [DOI] 10.3390/pharmaceutics13111954 PMC 바로가기 [Article Type] Article
Association between serum retinol and overall and cause-specific mortality in a 30-year prospective cohort studyArticle Published on 2021-11-052022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] alcohol Analysis association beta-carotene body mass index cardiovascular diseases cause-specific mortality circulation Cohort Concentration concentrations CVD death Diabetes Mellitus disease Effect Epidemiology Follow-up follow-up time Health indicated intensity lower mortality risk lower risk lowest mediation men Mortality Nutrition disorders overall mortality participant prospective cohort study Respiratory disease respiratory diseases retinol risk serum significantly lower smoking subgroup Trial Vitamin vitamin A [DOI] 10.1038/s41467-021-26639-4 PMC 바로가기 [Article Type] Article
Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal EnteroidsResearch Article Published on 2021-11-032022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acute gastroenteritis acute respiratory syndrome Affect all age groups antiviral agent Antiviral compound antiviral drug antiviral therapy approved compound screen compound screening concentrations coronavirus Culture dasabuvir demonstrated develop drug drug candidate effective highlighting Human identify Infection inhibit inhibited inhibitor inhibitory effect intestinal intestinal enteroids intestines knowledge Norovirus pathogen platform replicate reported SARS-CoV-2 screened treat Vaccine Viral gastroenteritis virus [DOI] 10.1128/mSphere.00623-21 PMC 바로가기 [Article Type] Research Article
Occurrence, Fate, Effects, and Risks of Dexamethasone: Ecological Implications Post-COVID-19Review Published on 2021-10-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Administered anti-inflammatory drug Aquatic ecosystems cause concentrations contaminant coronavirus disease COVID-19 crustacean Deleterious demonstrated Dexa Dexamethasone downstream drinking water drug ecological ecological implication Effect Effects fish glucocorticoid hospitalizations hospitalized COVID-19 patients implication IMPROVE infections management molecular Occurrence organism outbreak outcome plants raised reduction released SARS-CoV-2 Surface water susceptible transformation treat Treatment wastewater whole organism widespread [DOI] 10.3390/ijerph182111291 PMC 바로가기 [Article Type] Review
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive PatientsSARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과Article Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA [DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion PeptidesArticle Published on 2021-10-102022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alkaloid alkaloids alteration antiviral action antiviral therapy calcium cholesterol composed Compound concentrations coronavirus COVID-19 decrease demonstrated Effect effective Efficiency fluorescence microscopy fragment fusion fusion peptide greater in vitro indicated inhibit inhibitory investigated knowledge Lipid Mediated membrane membrane fusion MERS-CoV non-toxic Novel coronavirus pandemic peptides Phosphatidylcholine physical piperine plant Prevent progeny reduce SARS-CoV2 scattering shown significant changes in significantly suppress tested Vero Cell Vesicle viral fusion inhibitor [DOI] 10.3390/biomedicines9101434 PMC 바로가기 [Article Type] Article
Microdebrider is less aerosol-generating than CO 2 laser and cold instruments in microlaryngoscopyLaryngology Published on 2021-10-082022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] aerosol Aerosol generation aerosol-generating procedures Aerosols Airborne transmission Algorithm CO2 laser Cold instruments collected Concentration concentrations coughing COVID-19 equipment evaluated generate highest Infection investigated laryngeal laryngology less Microdebrider Microlaryngeal surgery objective occur Operating room Particle Particles produced Result significantly higher Spread surgical Volunteer [DOI] 10.1007/s00405-021-07105-9 PMC 바로가기 [Article Type] Laryngology
Serum IgG anti-SARS-CoV-2 Binding Antibody Level Is Strongly Associated With IgA and Functional Antibody Levels in Adults Infected With SARS-CoV-2혈청 IgG 항-SARS-CoV-2 결합 항체 수준은 SARS-CoV-2에 감염된 성인의 IgA 및 기능적 항체 수준과 밀접한 관련이 있습니다Immunology Published on 2021-10-082022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] ACE-2 receptor acute respiratory syndrome Adults age anti-S anti-S antibody anti-S ELISA anti-SARS-CoV-2 antibody binding antibody concentrations coronavirus coronavirus disease correlation COVID-19 cumulative cutoff value demographic groups demonstrated diagnostic disease severity ELISA ELISAs Endemic enzyme Epidemiology evaluate evaluated female full length full-length functional functional antibody human serum IgA IgG immunosorbent Level male Negative predictive value neutralizing antibody NPV pandemic positive Positive predictive value PPV Protein Quantitative reported Result robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 PCR SARS-CoV-2 seroprevalence sensitivity sera Serological assay serology serum dilution Significant significantly higher specificity Spread Surveillance Symptom Test statistics to define vaccine candidate were measured Wuhan, China yielding [DOI] 10.3389/fimmu.2021.693462 PMC 바로가기 [Article Type] Immunology
Paper-based aptamer-antibody biosensor for gluten detection in a deep eutectic solvent (DES)깊은 공융 용매에서 글루텐 검출을위한 종이 기반 앱 타머-항체 바이오 센서 (DES)Research Paper Published on 2021-10-062022-09-01 Journal: Analytical and bioanalytical chemistry [Category] MERS, 진단, [키워드] Abstract antibody approach Aptamers assays biosensor blood sugar carbon concentrations COVID-19 Deep eutectic solvents DES detect dynamic range Electrochemical detection Final Gluten ingestion limit limit of detection medium paper Paper-based biosensor platform Pregnancy pregnancy tests Rapid tests solvent sugar [DOI] 10.1007/s00216-021-03653-5 PMC 바로가기 [Article Type] Research Paper
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studiesResearch article Published on 2021-10-012022-10-05 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] Antiviral agents antiviral drug binding binding pocket biochemical cellular cleave colloid complexes concentrations coronavirus counter ion COVID-19 Crystallography demonstrated derivative effective inhibitor Efficacy form GC376 analogs group Improved increase increased solubility inhibitor main protease media MPro nanomolar affinity NMR physical polar protease Protease inhibitor replacement reported SARS-CoV-2 SARS-CoV-2 Mpro Structure Structure-guided design therapeutic Viral proteins [DOI] 10.1016/j.ejmech.2021.113584 [Article Type] Research article