Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study일본 COVID-19 환자의 중병 발병을 예측하는 초기 임상 요인: 단일 센터, 후향적, 관찰 연구Observational Study Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 임상, [키워드] Admission Analysis Asymptomatic characteristic clinical factor clinical factors Comorbidity coronavirus coronavirus disease coronavirus disease-2019 COVID-19 CoVs Cox proportional hazard Cox proportional hazards analysis Critical Critical disease cutoff value disease Disease progression EGFR elevated elevated lactate dehydrogenase enrolled evaluated excluded Factor filtration rate glomerular filtration rate hospital Hospitalized Japanese Japanese patients Laboratory laboratory finding laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Logistic lymphocytopenia male mechanical ventilation median age median time Mild mild to moderate moderate not significant Patient patients with COVID-19 Pediatric patients progression receiver operating characteristic retrospective risk factor Risk factors significantly single-center statin symptom onset [DOI] 10.1002/jmv.26599 PMC 바로가기 [Article Type] Observational Study
Bovine Coronavirus and the Associated DiseasesVeterinary Science Published on 2021-03-312022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] antigenic Betacoronavirus Bovine coronavirus bovine respiratory disease complex cattle Characteristics complex CoV CoVs cross diagnostics diarrhea disease ENCODE enteric Epidemics Epidemiology example Fever Genetic global public health highlight humans immune responses infect mammalian marker Middle East Modification Neonatal non-structural protein Older Pathogenesis Quasispecies respiratory RNA genome RNA synthesis SARS-CoV SARS-CoV-2 pandemic tissue tropism Transmission Vaccines variable wild ruminants zoonotic transmission [DOI] 10.3389/fvets.2021.643220 PMC 바로가기 [Article Type] Veterinary Science
Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus TrackingResearch Article Published on 2021-03-302022-10-29 Journal: mBio [Category] Coronavirus, [키워드] average caused caveolae Cell cell membrane clathrin Clathrin-mediated endocytosis complex coronavirus Course CoV CoV infection CoVs Dissection dynamic Endocytic pathway endocytosis endosome endosome trafficking Endosomes epidemic diarrhea Epidemics Evidence exhibiting expand Human Infection late endosome late endosomes mechanism Mediated occurred Pathways PEDV penetrate Penetrating plasma membrane porcine epidemic diarrhea coronavirus recruitment severe disease single-virus tracking Structure structures Transport undergo viral fusion viruses [DOI] 10.1128/mBio.00256-21 PMC 바로가기 [Article Type] Research Article
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemicCOVID-19 전염병으로 이어지는 SARS-CoV-2 출현 후 1년 동안 배운 교훈Review Published on 2021-03-222022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] 2003 SARS acute respiratory syndrome Animal coronaviruses animals Antiviral treatment approach bat bats Betacoronavirus caused clinical manifestations common cold common cold coronavirus Compliance Contact tracing coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 pandemic CoVs Culture deaths diagnostics Efficacy Epidemic Epidemics Epidemiology exotic H1N1 habit Human human coronavirus human coronaviruses hygiene hypothetical indicate infection control Influenza ingredient Laboratory lesson magnitude mammal mammals management MERS Middle East Middle East respiratory syndrome novel virus pandemic Pandemics Pathogenesis pathology plague respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-3 Severe acute respiratory syndrome severe disease severity syndrome transmission of SARS-CoV-2 Travel Treatment vaccination Vaccine Vaccines Virology virus variant viruses [DOI] 10.1080/22221751.2021.1898291 PMC 바로가기 [Article Type] Review
Human coronaviruses and therapeutic drug discoveryScoping Review Published on 2021-03-162022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] acting acute respiratory syndrome advance Adverse reaction antiviral drug carried Chinese clinical trial CNKI conducted coronavirus CoV COVID-19 pandemic CoVs drug Drug development Drug discovery drugs targeting Effect Effectiveness effort English Host Human human coronavirus immune system infecting information inhibiting outbreak pharmacological plant proliferation recommendation Research SARS-CoV-2 spread of COVID-19 susceptible target therapeutic drug virus [DOI] 10.1186/s40249-021-00812-9 PMC 바로가기 [Article Type] Scoping Review
Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and InfectionVaccines and Antiviral Agents Published on 2021-03-102022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] 229E acute respiratory syndrome Antibody Response Betacoronavirus binding common cold coronavirus CoV CoVs cross-react cross-reactive cross-reactivity DNA expressing facilitate full-length spike protein highlight HKU1 Humoral immunity immunization implication induce Infection macaque Neutralizing Neutralizing antibodies Neutralizing antibody response NHPs NL63 observation OC43 other coronavirus other coronaviruses pandemic polyclonal profile pseudoviruses RBD reactivity Receptor binding domain response rhesus macaque rhesus macaques robust sarbecovirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum similarity Spike protein Spike proteins the SARS-CoV-2 the vaccine vaccination Vaccine Vaccines was reduced [DOI] 10.1128/JVI.00117-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Recent Progress in Torovirus Molecular BiologyReview Published on 2021-03-082022-10-28 Journal: Viruses [Category] COVID-19, [키워드] addition Asymptomatic Biology bovine caused coronavirus CoV CoVs cultured cells diarrhoea enteric disease enteric diseases equine exacerbate genetics host adaptation humans Infection Molecular biology non-structural proteins pathogen Pathogenesis Progress recent Replication Research reverse genetics similarity Spread structural proteins Symptoms Tobaniviridae torovirus Transcription [DOI] 10.3390/v13030435 PMC 바로가기 [Article Type] Review
Computational drug repurposing study of the RNA binding domain of SARS-CoV-2 nucleocapsid protein with antiviral agentsArticle Published on 2021-03-012023-07-13 Journal: Biotechnology progress [Category] SARS, [키워드] COVID-19 CoVs Drug repurposing MD simulations molecular docking N protein RNA binding domain SARS-CoV-2 [DOI] 10.1002/btpr.3110 PMC 바로가기
Nucleic acid visualization assay for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by targeting the UpE and N geneResearch Article Published on 2021-03-012022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome amplification approach approved Atypical Clinical symptoms confirmed case coronavirus cough CoVs cross-reactivity detect diagnosed diagnostic Disease surveillance effective equipment evaluated exhibited Fever fluorescent gastrointestinal symptoms gold standard Guidance HKU1 human coronaviruses 229E IMPROVE Infection Laboratory Laboratory testing lack less limit of detection MERS MERS-CoV Middle East molecular N gene nucleic acid OC43 occur outbreak Outbreaks pandemic Patient Pneumonia point-of-care polymerase Prevent provide real-time RT-PCR reported respiratory respiratory pathogen respiratory syndrome coronavirus reverse transcription RT-PCR RT-qPCR assays SARS-CoV-2 SARSr-CoV Saudi Arabia sensitivity Sensitivity and specificity Shortness of breath temperature Treatment tropical Vaccine Viral RNA [DOI] 10.1371/journal.pntd.0009227 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2, the pandemic coronavirus: Molecular and structural insightsSARS-CoV-2, 대유행 코로나바이러스: 분자 및 구조적 통찰력Review Published on 2021-03-012022-09-11 Journal: Journal of basic microbiology [Category] SARS, 조류인플루엔자, 치료법, [키워드] ACE2 acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host Betacoronavirus bioinformatics causative pathogen Characteristics coronavirus CoV COVID-19 CoVs crystal structure crystal structures domain enzyme Evolution furin furin cleavage site Genetic Genome genome analysis genus genus Betacoronavirus Haplotype haplotypes Host Human information life cycle mammalian molecular Mutation natural selection Novel coronavirus outbreak pandemic pandemic coronavirus pangolin Pathogenesis polybasic Protein protein-protein interaction provide RBD reported S1/S2 cleavage site sarbecovirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-CoV-2 proteins secondary structure secondary structures severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein Spike protein Spread subgenus the disease the SARS-CoV-2 the SARS-CoV-2 genome transfer transmitted unique virus Virus evolution viruses zoonotic [DOI] 10.1002/jobm.202000537 PMC 바로가기 [Article Type] Review