The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamstersArticle Published on 2022-02-012022-10-27 Journal: Antiviral Research [Category] COVID-19, [키워드] B.1.1.529 bronchopneumonia COVID-19 COVID-19 pandemic D614G demonstrated detectable End exacerbated hamster hamsters histopathological infect Infectious virus Infectivity Inflammation log lung Lungs mutated new SARS-CoV-2 omicron Omicron variant organ pathology replicate SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC the lungs a the spike protein variant viral RNA load WHO [DOI] 10.1016/j.antiviral.2022.105253 PMC 바로가기 [Article Type] Article
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamstersArticle Published on 2022-02-012022-10-27 Journal: Antiviral Research [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] B.1.1.529 bronchopneumonia COVID-19 COVID-19 pandemic D614G demonstrated detectable End exacerbated hamster hamsters histopathological infect Infectious virus Infectivity Inflammation log lung Lungs mutated new SARS-CoV-2 omicron Omicron variant organ pathology replicate SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC the lungs a the spike protein variant viral RNA load WHO [DOI] 10.1016/j.antiviral.2022.105253 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo Research Published on 2022-02-012022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta cathepsin Cell cellular tropism Culture D614G Delta dependent on determinant epidemiological epidemiological studies evade evaluated Ex vivo exceptional explain faster global public health Human human bronchus human lung immune evasion Immunity Infection intrinsic less lung lung parenchyma Lungs multifactorial natural infection omicron other variant other variants reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 variant severity tested TMPRSS2 Transmissibility variant variant of SARS-CoV-2 variants of concern Virological wild type wild-type virus [DOI] 10.1038/s41586-022-04479-6 [Article Type] Research
Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein StabilitySARS-CoV-2 스파이크 B.1.1.7 및 B.1.351 변이체의 기능 상태에서 구조적 유연성 및 국부적 좌절: 기능 역학 및 단백질 안정성의 돌연변이 유발 알로스테릭 조절 메커니즘Article Published on 2022-01-312022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 host receptor allosteric interactions allosteric regulation Analysis B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants binding characterized conformational conformational change conformational dynamics conformational state D614G driver Dynamics Effect flexibility forms Frustration functional greater host cell host cell receptor hotspot identify inter-protomer interface intrinsic local frustration mechanism modulation molecular Molecular simulation molecular simulations mutant Mutation mutational scanning mutational variants open plasticity Protein protein stability receptor Region regulate Regulation required residue SARS-CoV-2 B.1.1.7 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins spike Spike protein Spike proteins spike variant spike variants stability state suggested the SARS-CoV-2 the spike protein Trajectories trajectory Transmissibility variant virus infectivity [DOI] 10.3390/ijms23031646 PMC 바로가기 [Article Type] Article
Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal포르투갈에서 확인 된 SARS-COV-2의 고주파 돌연변이를 갖는 슈도 바이러스의 감염성 및 항원 성Original Article Published on 2022-01-272022-09-10 Journal: Archives of Virology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antigenicity B.1.1.7 binding domain caused cell line coronavirus Cross-species transmission D614G Effectiveness Efficacy Epidemic epidemiological Epidemiological investigation evade evaluated hACE2 Health host immunity Huh7 immunized infect Infectivity monoclonal antibodies monoclonal antibody mouse serum mutant mutant strain Mutant strains mutants Mutation N439K N501Y neutralization activity Neutralizing activity nine overexpressing Portugal Prevalence Prevention and control pseudovirus pseudoviruses Receptor binding domain reduced Region regions respiratory S477N SARS-CoV-2 SARS-CoV-2 mutation severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spike protein Spread strain Strains supplementary material susceptible cell tested Vaccine Vaccines Variation Vero was performed was used weakened were used [DOI] 10.1007/s00705-021-05327-0 PMC 바로가기 [Article Type] Original Article
Whole-Genome Sequencing of SARS-CoV-2 Strains from Asymptomatic Individuals in IndiaGenome Sequences Published on 2022-01-272022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome Asymptomatic individuals clade collected coronavirus coronavirus disease COVID-19 D614G First wave Genome sequencing GISAID India individual Lineage Mutation nasopharyngeal Nextstrain Oropharyngeal performed SARS-CoV-2 sequenced Spike protein strain Strains [DOI] 10.1128/MRA.00850-21 PMC 바로가기 [Article Type] Genome Sequences
Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjectsResearch Article Published on 2022-01-212022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Affect affecting approach binding affinity binding epitope characterized cleavage site Community COVID-19 COVID-19 positive subject D614G D614G mutation deep sequencing diffusion effort epitope evidence of evidenced Fiumicino HLA alleles identify immune response implication Infection Italy modulation MONITOR mutated Mutation next generation sequencing objective peptide Protein Proteins reported respiratory sample Result S939F SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selective Sequencing analysis severity specific mutation spike spike mutations stability subject T-cell triggered unique viral infection was performed was used [DOI] 10.1016/j.csbj.2022.01.021 PMC 바로가기 [Article Type] Research Article
COVID-19 Delta variation; more contagious or more pernicious?COVID-19 델타 변종; 더 전염성이 높거나 더 유해합니까?Article Published on 2022-01-192022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] SARS, 변종, [키워드] advancement Analysis B.1.617 B.1.617.2 contagious country COVID-19 COVID-19 pandemic D614G Delta delta variant distribution dominant Epidemiology Evolution G142D genomic high mortality rate India individual initial L452R Lineage lineages mortality rate much higher Mutation P681R pathogenic virus prevalent proceed RBD Receptor-binding domain SARS-CoV-2 SARS-CoV-2 delta Spike protein the epidemic the receptor-binding domain the spike protein transfer variant Variation variations VoC whole-genome sequencing [DOI] 10.23750/abm.v92i6.12181 PMC 바로가기 [Article Type] Article
A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-22가 나노입자 백신은 SARS-CoV-2 변종에 대한 강력한 교차 보호를 나타냅니다.Article Published on 2022-01-182022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin B.1.351 B.1.351 variants bivalent nanoparticle vaccine. boost coronavirus cross-neutralizing antibodies cross-neutralizing antibody cross-protection D614G dose elicit exhibit human Angiotensin-converting enzyme immune evasion Infection infection with SARS-CoV-2 initial inoculation mice Neutralizing antibodies neutralizing antibody Prevent RBDs Receptor binding domain receptor binding domains rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single dose Strains transgene Vaccine variants variants of SARS-CoV-2 [DOI] 10.1016/j.celrep.2021.110256 PMC 바로가기 [Article Type] Article
Cross-sectional genomic perspective of epidemic waves of SARS-CoV-2: A pan India studySARS-CoV-2 전염병 파동의 단면 게놈 관점: 범인도 연구Article Published on 2022-01-152022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affecting Analysis average coding COVID-19 cross-sectional D614G Deadly variants downloaded elevated Epidemic epidemic wave event Evolution extragenic First wave Genome Genome-wide genomes genomic inception incidence India investigated isolate management Mutation mutation rate Mutation rates NC_045512.2 Non-synonymous NSP pandemic Perspective Phylogeny RdRP reported representing RNA RNA dependent RNA polymerase SARS-CoV-2 second wave Seven silent Silent mutation SNP spike the epidemic UTR VoC VOCs VOI VOI. VOIs was obtained was performed Wuhan [DOI] 10.1016/j.virusres.2021.198642 PMC 바로가기 [Article Type] Article