Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks내피 기능 장애는 조절 이상 림프구 반응 및 사이토카인 네트워크와 함께 심각한 COVID-19에 기여합니다Observational Study Published on 2021-12-102022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상, 진단, 치료법, [키워드] activated Activation acute disease Adaptive immunity addition analyses Analysis change Clustering Combination contribute convalescent patient Convalescent patients COVID-19 cytokine disease Disease progression driven by dysfunction dysregulated dysregulation endothelial endothelial injury endothelial integrity expansion flow cytometry granulocyte Granulocytes hallmark hallmarks Hannover ICU patient ICU Patients Immune cell immune cells immune response immune responses immune signature Infectious diseases Inflammatory Inflammatory response Injury involved life-threatening lymphocyte response lymphopenia manifestation medical school microenvironment NK cell observational study plasma protein plasma proteins plasmablast plasmablasts proteomics data regeneration SARS-COV-2 infection SARS-CoV-2-specific antibodies School Seven severe COVID-19 terminally differentiated [DOI] 10.1038/s41392-021-00819-6 PMC 바로가기 [Article Type] Observational Study
Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019심각한 코로나 바이러스 질병 2019의 잠재적으로 수정 가능한 위험 요소로서의 비타민 K 상태 감소Article Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] accelerated activate activated Activation acute respiratory syndrome Anticoagulant arterial calcification coagulation factor Coagulation factors Computed tomography Control controls Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients Degradation desmosine elastic fiber elastic fibers elevated endothelial Factor factor II fiber hospitalized COVID-19 patient implicated Matrix Gla Protein MGP outcome Patient patients procoagulant procoagulant factor PROTECT Protein protein S Proteins prothrombin remained required respiratory Respiratory failure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severity status These data Thoracic thromboembolic disease Thromboembolism thrombosis Vascular Vitamin vitamin K was measured was related were measured [DOI] 10.1093/cid/ciaa1258 PMC 바로가기 [Article Type] Article
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19내피 글리코칼릭스 분해의 지표인 신데칸-1, 코로나19로 중환자실에 입원한 환자의 결과 예측Research Article Published on 2021-12-032022-09-10 Journal: Molecular Medicine [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Coagulopathy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Degradation demographic destruction develop endothelial endothelial damage Endothelial glycocalyx examined feasibility glycocalyx greater ICU increased mortality indicated Inflammation inflammatory reactions intensive care intensive care unit interleukin interleukin-6 investigated Kaplan–Meier survival analysis laboratory data log-rank test marker median Mortality non-survivor not significantly different outcome Patient Potential treatment predict progression Protecting Result serum severity of COVID-19 significantly higher supplementary material survival survival analysis survivor Survivors syndecan Syndecan-1 thrombomodulin Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α two group Variation with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s10020-021-00412-1 PMC 바로가기 [Article Type] Research Article
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreakObservational Study Published on 2021-12-012022-10-05 Journal: The British journal of dermatology [Category] 임상, [키워드] Activation Angiogenesis antibody Biomarker Blood Cell characterized chilblain clinical manifestations CLL complement conducted COVID-19 outbreak COVID-19 pandemic cytoplasmic defined elevated endothelial Endothelial dysfunction excluded exclusion Factor France gene signature groups healthy control healthy controls IgA immune infiltration immune system interferon response lesion outbreak overlapped Paris pathophysiology Patient patients reported SARS-COV-2 infection Support systemic immune response tissue transcriptomic Type type I type I interferon Vascular [DOI] 10.1111/bjd.20707 PMC 바로가기 [Article Type] Observational Study
Use of novel antithrombotic agents for COVID-19: Systematic summary of ongoing randomized controlled trialsCOVID-19에 대한 새로운 항혈전제의 사용: 진행중인 무작위 대조 시험의 체계적인 요약Article Published on 2021-12-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 임상, 치료제, [키워드] acting Activation affecting Anti-inflammatory Antithrombotic Antiviral antiviral effects benefit clinical coagulation cascade Coagulopathy Conventional coronavirus disease Coronavirus disease 2019 COVID-19 defibrotide drug Effect endothelial Endothelial cell fibrosis Health Organization help identify IMPROVE include Inflammatory response macro management mechanism nafamostat Oxygenation Patient Patient management patients with COVID-19 pleiotropic potential mechanism Randomized controlled trial Randomized controlled trials RCT RCTs reduce registry Result searched systematic literature search Trial triggered utility Viral load World Health Organization [DOI] 10.1111/jth.15533 PMC 바로가기 [Article Type] Article
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 InfectionSARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘, [키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score [DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis
Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19: A Placebo-Controlled, Randomized TrialResearch article Published on 2021-12-012022-10-05 Journal: JACC: Basic to Translational Science [Category] 바이오마커, 임상, [키워드] assigned Biomarker characterized Clinical endpoints coronavirus COVID-19 crizanlizumab D-dimer level double-blind Effect Elevation endothelial endothelial cells Exocytosis induce Inflammation inhibitor no significant difference P-selectin P-Selectin Inhibitor patients with COVID-19 patients with moderate Placebo Randomly receive reduced released tested thrombosis treating vascular inflammation Vasculopathy [DOI] 10.1016/j.jacbts.2021.09.013 [Article Type] Research article
Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings혈청 용해성 내피 단백질 C 수용체 수치와 코로나19 소견과의 관계Article Published on 2021-12-012022-09-11 Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 치료기술, [키워드] activated Admission anti-inflammatory activity Anticoagulant association biochemical blood specimen blood specimens Chain Reaction clinically Coagulation coagulation cascade Coagulopathy collected Complication Computed tomography Course COVID-19 COVID-19 patient detect diagnosed e parameters endothelial enrolled EPCR GGO ground-glass opacity group Inflammation inflammatory process laboratory parameter Laboratory parameters laboratory-confirmed leads member negative patients no difference onset of symptom parameter Patient PCR positive Protein protein C qPCR test receptor reduce related disease relationship reported reverse transcription RT-qPCR RT-qPCR test serum shown significantly higher Symptoms Thorax thrombosis was performed [DOI] 10.1097/MBC.0000000000001070 PMC 바로가기 [Article Type] Article
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV StudyCardiovascular Medicine Published on 2021-11-302022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute COVID-19 age Analysis Care chest pain clinical status Coronary heart disease COVID 19 COVID-19 COVID-19 disease COVID-19 patient COVID-19 symptoms cross-sectional determine diabetes Diagnosis disease dysfunction Effect endothelial Endothelial dysfunction endothelial function Endothelium female gender hypertension independent risk factor Infection Injury insight large cohort Long Long COVID-19 syndrome Microcirculation multicenter observational study need for oxygen Patient patients Polymath recruitment severity Sex significantly Symptom Symptoms syndrome Vascular endothelium [DOI] 10.3389/fcvm.2021.745758 PMC 바로가기 [Article Type] Cardiovascular Medicine
COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory AnalysisCOVID-19 백신 관련 혈전증: 체계적인 검토 및 탐색적 분석Immunology Published on 2021-11-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 Adenovirus adenovirus-based Admission adverse effect adverse event adverse events affected age antibodies antibody appearance article assumed AstraZeneca Atypical binding caused complex Complication coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine Critical database Descriptive analysis DNA endothelial Endothelial cell endothelial cells events except for expressing Features female Genetic headache Health Organization heparin heparin-induced thrombocytopenia heterogeneity High-risk patients hypothese identify individual Inflammatory inoculation limit male material mechanism Moderna mRNA mRNA-based negative charge New normal range outcome pandemic pathophysiological mechanism pathophysiological mechanisms Patient performed petechiae PF4 PF4 antibodies Pfizer physiopathological mechanism Platelet Platelet count positive predisposition Prevalence prevalent Protein purpura recent remained Result review secondary to selected Symptom the patient thrombocytopenia thrombosis thrombotic Thrombotic thrombocytopenia vaccination Vaccine vaccine adverse effects vaccine complications vaccine-related thrombosis Vaccines variant venous venous sinus Viral viral DNA Viral vector viral vectors World Health Organization [DOI] 10.3389/fimmu.2021.729251 PMC 바로가기 [Article Type] Immunology