Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향Review Published on 2021-07-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake [DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review
Development of Corona-virus-disease-19 VaccinesReview Article: COVID-19 Published on 2021-07-092022-10-30 Journal: JMA Journal [Category] COVID-19, [키워드] activities acute respiratory syndrome animal model beta coronavirus blockade cause caused coronavirus COVID-19 described development diamond died disease Epidemic epithelial cell global pandemic infect Japan lung MERS-CoV New coronavirus outbreak Pneumonia Princess respond SARS Coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 vaccine therapeutic agent Vaccine VADE Viral pneumonia virus worldwide pandemic Wuhan, China Yokohama [DOI] 10.31662/jmaj.2021-0068 PMC 바로가기 [Article Type] Review Article: COVID-19
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammationRIG-I 및 MDA5에 의한 SARS-CoV-2 감지는 상피 감염을 대식세포 염증과 연결합니다Article Published on 2021-07-022022-09-10 Journal: The EMBO Journal [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation airway airway epithelial cell airway epithelial cells cause Cell cellular activation COVID‐19 cytokine cytokine production cytoplasmic develop disease downstream effective ENhance epithelial epithelial cell epithelial cells exacerbate exacerbated human macrophage immunology immunopathological induce Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inflammatory state inflammatory stimuli inhibiting innate immune pathway innate immune pathways innate immune response Local lung epithelial cell Lung epithelial cells lung epithelium Macrophage macrophage activation macrophages MDA5 mechanism mediators Microbiology, Virology & Host Pathogen Interaction mitigate Pathways produced replicate required RNA RNA sensing robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 stimulate triggering [DOI] 10.15252/embj.2021107826 PMC 바로가기 [Article Type] Article
Salivary glands are a target for SARS-CoV-2: a source for saliva contamination침샘은 SARS-CoV-2의 표적입니다: 타액 오염의 원인Article Published on 2021-07-012022-09-11 Journal: The Journal of pathology [Category] SARS, 치료기술, 치료법, 치료제, [키워드] ACE2 acinar cell age alteration Analysis analyzed anti-SARS-CoV-2 antibody Autopsy biopsy Cell cells change characterized Cluster conducted Contamination Coronaviridae family COVID-19 COVID-19 pandemic cytoplasm cytoplasmic degeneration degenerative determinant determinants Diagnostic method duct electron microscopy enlarged nuclei epithelial cell epithelial cells expression female Granule Great Britain highlight histopathological identify immunohistochemistry infected cell infected cells Infection infection control Ireland lining epithelium male Microscopy nasopharyngeal swabs New coronavirus new coronavirus SARS-CoV-2 nuclear nuclear pleomorphism nucleocapsids organelle pathological pathophysiological Patient patients positive profile Qualitative Quantitative receptors reservoir RT-PCR RT-PCR, SARS-CoV-2 RT-qPCR Saliva salivary salivary gland salivary gland. salivary glands Sample SARS-CoV-2 sensitivity shape Society Sons Spread tested the Coronaviridae the disease TMPRSS Ultrasound vacuolization Viral particles viral replication [DOI] 10.1002/path.5679 PMC 바로가기 [Article Type] Article
Broad antiviral and anti‐inflammatory efficacy of nafamostat against SARS‐CoV‐2 and seasonal coronaviruses in primary human bronchiolar epitheliaResearch Article Published on 2021-06-302022-10-29 Journal: Nano Select [Category] COVID-19, [키워드] Activation airway epithelia airway epithelium anti‐inflammatory Antiviral antiviral activity antiviral effects antiviral property block bronchiolar Cell chronic obstructive COVID‐19 cytokine Donor Effect Efficacy epithelia epithelial cell evaluate exhibit healthy donors help Host host protease host serine protease human coronaviruses human coronaviruses 229E independent infect Inflammation inhibit log mitigate nafamostat Nafamostat mesylate observé Pathogenesis primary human airway pulmonary disease reduce reduction Replication respiratory infection SARS‐CoV‐2 SARS‐CoV‐2 seasonal coronavirus serine protease inhibitor smoker subject therapeutic therapeutic potential TMPRSS2 Treatment viral spike protein virus infection [DOI] 10.1002/nano.202100123 PMC 바로가기 [Article Type] Research Article
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced [DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology
A novel anti‐inflammatory treatment for bradykinin‐induced sore throat or pharyngitisOriginal Article Published on 2021-06-212022-10-30 Journal: Immunity, Inflammation and Disease [Category] Coronavirus, MERS, SARS, [키워드] A549 cells absence acetyl acetyl salicylic acid alveolar analyzed antibiotic Aspirin bradykinin complex mechanism concentrations COVID‐19 COX described disease Epiairway epithelia epithelial cell exacerbate exacerbated Health IL‐8 immunohistochemistry increase in Inflammation Inflammatory inflammatory condition inflammatory mediator ingredient inhibitor involved lactate dehydrogenase LDH likelihood low dose LTB4 medication mitigate morphology MucilAir nonspecific PGE2 pharyngitis prostaglandin public health Respiratory complications respiratory epithelia respiratory tissue respiratory tissues Result sore throat stimulated Symptom TEER the cell therapeutic window therapy thought tissue transepithelial electrical resistance Treatment treatment effect upper respiratory was measured were used [DOI] 10.1002/iid3.479 PMC 바로가기 [Article Type] Original Article
ELV-N32 and RvD6 isomer decrease pro-inflammatory cytokines, senescence programming, ACE2 and SARS-CoV-2-spike protein RBD binding in injured corneaArticle Published on 2021-06-172022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome affecting angiotensin-converting enzyme 2 binding Bioactivity cause contribute Corneal coronavirus coronavirus disease COVID-19 Culture cytokine damaged decrease Drug discovery epithelial cell expression furin hyper-inflammation IFNγ in vivo Infection Inflammation integrin lipid mediator mitigate pandemic pro-inflammatory cytokines programming Protein public health crisis RBD RBD binding Resolvin RNA-seq analysis SARS-CoV-2 spike the receptor-binding domain therapeutic Treatment triggering viral infection virus [DOI] 10.1038/s41598-021-92293-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1SARS-COV-2 엔벨로프 (E) 단백질은 숙주 단단한 접합 단백질 ZO1의 PDZ- 도메인 -2와 상호 작용한다.Research Article Published on 2021-06-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 진단, [키워드] airway amplified approach approaches array binding Biotin C-terminal cell layer chloride complementary consolidation contribute contributing to COVID-19 patients disease severity domain dysfunction E protein ECT envelope epithelial epithelial cell epithelial cells epithelial tissues extreme Fluorescence fusion protein global pandemic homogenous Host HTRF humans interact Interaction Intervention lead Lungs membrane protein mitigate molecular morbidity motif multifunctional mutant Pathogenesis Pathologies peptide Protein reduce respiratory Respiratory disease respiratory tract SARS-CoV-1 SARS-CoV-2 screened secretion sequence severe pneumonia severe respiratory disease singular target the lungs a the SARS-CoV-2 tight junction tissues virus virus spread Zona [DOI] 10.1371/journal.pone.0251955 PMC 바로가기 [Article Type] Research Article
PD-L1 Dysregulation in COVID-19 PatientsImmunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response ARDS biological sample blood sample caused CD4+ T cells clinical study consequence COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient cultures dysregulated dysregulated immune response dysregulation effective epithelial cell Evidence healthy donors healthy individuals hospitalized COVID-19 patient Host immune response identify Immune cell immune checkpoint molecules in vitro Infection inhibitors innate immune response Ligand manifestation Manifestations model system modulation Monocytes Neutrophils Patient PD-L1 Prognosis prognostic prognostic biomarker reached RNA expression SARS-CoV-2 Serum level subset T cell therapeutic approaches tissue tissue biopsy upregulation variety [DOI] 10.3389/fimmu.2021.695242 PMC 바로가기 [Article Type] Immunology