Extracellular – Page 12 – Communicable Diseases Research

Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study

COVID-19 환자에서 항체의 동적 특성 분석: 13개월 연구

Immunology

Published on 2021-07-202022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, 치료제,

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향

Review

Published on 2021-07-142022-09-10
Journal: Viruses [Category] SARS, 치료제,

[키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake
[DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review

Role of Extracellular Vimentin in Cancer-Cell Functionality and Its Influence on Cell Monolayer Permeability Changes Induced by SARS-CoV-2 Receptor Binding Domain

Article

Published on 2021-07-122022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] activated macrophages Activation activation pathway addition Alter angiotensin-converting enzyme 2 Astrocyte Bacterial bind binding binding domain Cancer Cancer cells cancer progression Cell Cell migration cells cellular change cytoskeletal domain Effect ENhance Extracellular extracellular space extracellular vimentin functional functions growth IGF-1 IGF-1 receptor induced Inflammation influence investigated involved MCF-7 Migration modulate modulation monolayer monolayers neutrophil infiltration overexpressed permeability physiological conditions proliferation promote Protein receptor Receptor binding domain reduced reduction role SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 receptor SARS-COV-2 receptor binding domain SARS-CoV-2 spike protein secreted shown Spike protein Support surface the SARS-CoV-2 Treatment vimentin viral infection while
[DOI] 10.3390/ijms22147469 PMC 바로가기 [Article Type] Article

Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection

SARS-COV-2 감염에 대한 항바이러스제 전달을 위한 바이러스 스파이크 단백질의 RBD로 태그가 지정된 세포외 소포

Article

Published on 2021-07-102022-09-11
Journal: Journal of controlled release : official journal o [Category] SARS, 치료제,

[키워드] accumulate ACE2 ACE2 receptor antiviral agent Antiviral agents approach binding domain Cell cellular cellular entry develop domain effective encapsulate endocytosed Express Extracellular extracellular vesicle Extracellular vesicles fusion hACE2 highlight in vivo Infection Interaction lung tissue lung tissues membrane membrane protein Membrane proteins modify molecular provide pseudovirus infection RBD Receptor binding domain receptor binding domain (RBD) Receptor-binding domain recognize required Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus siRNA siRNAs specific tissue specific tissues Spike protein spread of COVID-19 suppress Tagged target cells target tissue target tissues targeting the RBD the receptor-binding domain therapeutic potential Therapeutics tissue Transgenic mouse viral spike protein
[DOI] 10.1016/j.jconrel.2021.05.049 PMC 바로가기 [Article Type] Article

Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors

Microbiology

Published on 2021-07-082022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] acute respiratory syndrome blocked buffer Cell cell viability assay classical conserved contribute coronavirus E protein Effect effective envelope envelope protein epigallocatechin expressed expression Extracellular family Coronaviridae flavonoid genus Betacoronavirus HEK293 cell inflammasome activation inhibited inhibition inhibitor inhibitors inhibitory activity introduced involved ion channel inhibitors kDa membrane protein novel antiviral drug patch-clamp electrophysiology plasma membrane proliferation Protein quercetin RNA virus SARS CoV SARS CoV-1 SARS-CoV SARS-CoV E SARS-CoV-2 sequence signal peptide single-stranded positive-sense suppress tested transfer transmembrane viability viroporins virus Virus life cycle
[DOI] 10.3389/fmicb.2021.692423 PMC 바로가기 [Article Type] Microbiology

Pathogenesis of the inflammatory bowel disease in context of SARS-COV-2 infection

SARS-COV-2 감염의 맥락에서 염증성 장 질환의 병인

Review

Published on 2021-07-012022-09-12
Journal: Molecular biology reports [Category] SARS, 진단,

[키워드] ACE2 receptor Activation Adaptive immune response adaptive immune responses Adaptive immunity alveolar epithelial cells binding bowel carried Colitis consequence coronavirus COVID-19 Critical Crohn’s disease entry of SARS-CoV-2 expression Extracellular Factors gastrointestinal tract Genetic predisposition Host host cell IBD immune response increase in individual induce infecting Infection infection with SARS-CoV-2 Inflammation Inflammatory bowel disease inflammatory reaction initiate Innate Innate immunity intestinal intestinal enterocyte intestinal tissue molecular new SARS-CoV-2 pathway Patient patients proinflammatory cytokines receptor Research risk SARS-CoV-2 SARS-COV-2 infection Toll-like receptors ulcerative colitis virus
[DOI] 10.1007/s11033-021-06565-w PMC 바로가기 [Article Type] Review

Does Covera-19 know ‘when to hold ‘em or ‘when to fold ‘em? A translational thought experiment

Review

Published on 2021-06-302022-10-29
Journal: Translational Medicine Communications [Category] COVID-19,

[키워드] Acidic amino acid sequence change changes conformational change COVID-19 Effect electrical experiment Extracellular function furin histidine Host human host induce Protein receptor Repurposed drug Research SARS-CoV-2 survival thought translational Treatment
[DOI] 10.1186/s41231-021-00090-5 PMC 바로가기 [Article Type] Review

An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single dose

SARS-CoV-2에 대한 mRNA 기반 백신 후보는 단일 용량으로 안정적인 면역 반응을 이끌어냅니다.

Article

Published on 2021-06-232022-09-11
Journal: Vaccine [Category] MERS, SARS, 변종, 진단,

[키워드] animal model antibody architecture CD4+ cell CD4+ cells characterization clinic coronavirus COVID D614G D614G variant domain dose elicit Extracellular Formulation Genotype HEK293 cell HEK293 cells IgG immunization immunized mice immunologic response immunologic responses implicated Infection Lipid Lipid nanoparticle LNP mRNA-based vaccine neutralized product provide pseudoviruses purified RBD responsible SARS-CoV-2 SARS-CoV-2 virus single dose Spike protein SPR stable population suggested surface plasmon surface plasmon resonance Th1 the spike protein translation vaccination Vaccine vaccine candidate
[DOI] 10.1016/j.vaccine.2021.05.035 PMC 바로가기 [Article Type] Article

A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19

Research

Published on 2021-06-222022-10-05
Journal: Nature metabolism [Category] SARS, 유전자 메커니즘, 치료기술, 치료법,

T2-mapping increase is the prevalent imaging biomarker of myocardial involvement in active COVID-19: a Cardiovascular Magnetic Resonance study

T2 매핑 증가는 활성 COVID-19에서 심근 관련의 일반적인 이미징 바이오마커입니다: 심혈관 자기 공명 연구

Observational Study

Published on 2021-06-102022-09-10
Journal: Journal of Cardiovascular Magnetic Resonance [Category] MERS, SARS, 임상, 진단, 치료기술, 치료제,

[키워드] Abnormalities abnormality active phase Artery Biomarker cardiovascular Cardiovascular Magnetic Resonance change characterization clinical Cohort collected Comparisons control group Coronary arteries coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 diagnosis COVID-19 patients cTnT decrease Diagnosis disease Early detection edematous enrolled Evidence evidence of Extracellular fraction gadolinium healthy control healthy controls in vivo individual individuals Infection Inflammation IQR Laboratory laboratory characteristics laboratory findings linear correlation median moderate Myocardial myocardial damage Myocardial infarction myocardial injury myocardial involvement myocarditis Observational cohort study Occurrence parameters Patient patients Pericarditis positive linear correlation positively correlated predominant prevalent protocol Quantitative imaging referred to relationship resonance Result retrospective risk risk factor SARS-CoV-2 selected sensitivity Sex supplementary material Symptomatic treatment time interval tissue troponin troponin T Volume volume fraction
[DOI] 10.1186/s12968-021-00764-x PMC 바로가기 [Article Type] Observational Study