Korea’s Early COVID-19 Response: Findings and ImplicationsArticle Published on 2021-08-052022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] activities building complementary contain country COVID-19 COVID-19 pandemic effective effort finding Government hotspot Infection Korean mechanism outcome pandemic Pandemics press question second sequence South South Korea treated [DOI] 10.3390/ijerph18168316 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoidsResearch Published on 2021-08-052022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abietane diterpenes: Molecular docking ACE2 ACE2 binding African binding binding free energy catalytic Clustering analysis COVID-19 pandemic docked docking drug drug-likeness eight Entry inhibitor first stage hotspot human Angiotensin-converting enzyme in silico in vitro in vivo inhibiting inhibitory Interaction interactions MD simulation MERS-CoV molecular molecular docking analysis pentacyclic performed plant preserved protease Protein protein targets Proteins provide residue Result S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 spike protein screened serine 2 Spike protein stability supplementary material targeting targets terpenoids the RBD the SARS-CoV-2 therapeutic strategy TMPRSS2 trajectory transmembrane viral cell [DOI] 10.1186/s43141-021-00209-z PMC 바로가기 [Article Type] Research
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021Article Published on 2021-08-052022-10-04 Journal: Virus research [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome analyses association Brazil clade coronavirus country COVID-19 COVID-19 pandemic death deaths described disease distribution E484K effective strategy effort Epidemiology Evolution Frequency genome sequence genomic heterogeneous High-throughput nucleotide sequencing hotspot identify immune evasion improvement Infectious diseases information Lineage management Molecular epidemiology Mutation N501Y P.1 P.2 phylogenetics phylogeography Prevalence prevalent lineage progression public health reached Receptor binding regions SARS-CoV-2 SARS-CoV-2 lineage Sequencing Seven severe acute respiratory syndrome coronavirus 2 spatiotemporal Support Surveillance the spike protein [DOI] 10.1016/j.virusres.2021.198532 PMC 바로가기 [Article Type] Article
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapyResearch Article Published on 2021-08-052022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] Algorithm Analysis Cancer therapy CD4+ cell CD4+ T cell Cell cells changes in Chemotherapy clinical response comparable Complete COVID-19 COVID-19 patient Cytometry Disease progression emerging disease example homogeneous hotspot Human identify immune Immune cell immune changes Immune monitoring immune system immunology individual donor Infection inhibitor knowledge leukemia machine learning magnitude Melanoma MHCII Other Patient phenotype Post-infection provided reagent repeated reveal rhinovirus SARS-CoV-2 infections Single Cell subset Systems biology therapy trajectory virus virus-specific T cell [DOI] 10.7554/eLife.64653 PMC 바로가기 [Article Type] Research Article
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodiesSARS-COV-2 스파이크 단백질에서의 시그니처 중화 항체로의 탈출Research Article Published on 2021-08-052022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor Affect Alter Amino acid amino acid substitution amino acids Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody neutralization binding Cell changes in circulating Combination convalescent core COVID-19 Critical Determining develop diagnostics E484K elicited engage enzyme evade Evolution explanation grid Host host immunity hotspot identify Immune escape immune escape mutants immune evasion in silico increase Infection Interaction K417N lentivirus MONITOR Mutation mutations N501Y Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing-antibody Pandemics Protein provide provided pseudotyped lentiviruses Recognition reduce responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV2 sera shown signature specificity Spike protein target targets tested the spike protein Therapies understanding vaccination Vaccine variants variants of concern Viral Viral protein virion virus [DOI] 10.1371/journal.ppat.1009772 PMC 바로가기 [Article Type] Research Article
One year after first case of COVID-19 in Ghana: epidemiology, challenges and accomplishments가나에서 Covid-19의 첫 사례 1 년 후 : 역학, 도전 및 성취Perspectives Published on 2021-08-042022-09-10 Journal: The Pan African Medical Journal [Category] MERS, 치료제, [키워드] Accomplishments adverse impact affected African Antiviral approach caused challenges coronavirus disease Coronavirus disease 2019 country COVAX COVID-19 COVID-19 pandemic dose effective effort Epidemiology Ghana globe Government hand sanitizers Health Organization health system health systems help hotspot Isolation Local measure morbidity morbidity and mortality nation Novel coronavirus Oxford-AstraZeneca pandemic partial lockdown Personal protective equipment public health quarantine receive reported Spread Vaccine Vaccines virus WHO World Health Organization [DOI] 10.11604/pamj.2021.39.226.29069 PMC 바로가기 [Article Type] Perspectives
Main protease inhibitors and drug surface hotspots for the treatment of COVID-19: A drug repurposing and molecular docking approachCOVID-19 치료를 위한 주요 프로테아제 억제제 및 약물 표면 핫스팟: 약물 용도 변경 및 분자 도킹 접근Article Published on 2021-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] Coronavirus, 신약개발, 치료법, 치료제, [키워드] Absorption active site Alpha Amino acid amino acids Analysis approach approved binding binding affinity clinical trial conducted conformational control groups COVID-19 Critical derivative determine distribution docked complexes drug Drug repurposing drug-likeness effective Efficacy Favipiravir glecaprevir HCV HIV hotspot in silico analysis in vivo inhibitor inhibitors investigated lack Lopinavir Main protease protein (MPP) inhibitors metabolism molecular docking molecular dynamics nelfinavir paritaprevir pharmacokinetics predicted protease Protease inhibitor Protein RdRP Remdesivir RNA RNA dependent RNA polymerase SARS-CoV-2 screened stability suggested the SARS-CoV-2 therapeutic therapeutic agent Treatment treatment of COVID-19 was performed [DOI] 10.1016/j.biopha.2021.111742 PMC 바로가기 [Article Type] Article
Virtual screening and dynamics of potential inhibitors targeting RNA binding domain of nucleocapsid phosphoprotein from SARS-CoV-2SARS-CoV-2의 뉴클레오캡시드 인단백질의 RNA 결합 도메인을 표적으로 하는 잠재적 억제제의 가상 스크리닝 및 역학Article Published on 2021-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Antiviral binding binding domain binding energy binding free energy calculated coronavirus coronavirus disease COVID-19 database databases docking docking process docking score docking scores drug exonuclease fluctuation genetic material hotspot inhibitor Interaction Ligand mechanism molecular molecular dynamics Molecular dynamics simulation N protein nucleocapsid Nucleocapsid phosphoprotein nucleocapsid phosphoprotein. outbreak pandemic Potential treatment Precision PubChem PubChem database remained required RMSD RMSF RNA SARS-CoV-2 selected Site target target protein transcribed Transcription unique viral replication virion Virtual screening virus zidovudine [DOI] 10.1080/07391102.2020.1778536 PMC 바로가기 [Article Type] Article
Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a reviewReview Published on 2021-07-282022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] accounted Activation alleviate Anti-complement therapy Chinese chronic inflammation Coagulopathy complement Complement inhibitor contribute COVID-19 Critically ill Critically ill patient Cytokine storm drug resistance Efficacy Efficiency etiological hotspot immune response intravascular coagulation Mortality multiple organ failure natural natural products New organ dysfunction Perspective progressive respiratory failure reduction Regulation severity of COVID-19 Side effect supplementary material Symptom therapy Toxicity Treatment uncontrolled upstream with COVID-19 [DOI] 10.1186/s13020-021-00478-3 PMC 바로가기 [Article Type] Review
Resumption of the treatment of non‐ COVID ‐19 gynecologic patients after lifting lockdown: Triage and infection prevention experiences from WuhanOriginal Article Published on 2021-07-282022-10-31 Journal: The journal of obstetrics and gynaecology research [Category] COVID-19, SARS, [키워드] activity Admission Anemia body temperature buffering room Contact COVID COVID‐19 described effective Effectiveness gynecologic surgery hospitalized patients hotspot Infection prevention Isolation lifted lockdown nosocomial occurred outpatient clinic pandemic Patient patients Patients with cancer performed Personal protective equipment proportion required Result Safe screening test shown Symptom transferred Transmission Treatment Triage triage strategy Union Hospital was increased Wuhan [DOI] 10.1111/jog.14917 PMC 바로가기 [Article Type] Original Article