Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA미국 미주리주 세인트루이스의 소아 및 성인에서 SARS-CoV-2 항체의 혈청유병률Research Article Published on 2021-02-032022-09-12 Journal: mSphere [Category] MERS, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age antibodies antibody Asymptomatic case children collected confirmed case confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 credible interval demonstrated ELISAs enzyme-linked immunosorbent assay greater house IgG IgG antibodies IgG antibody individual Infection Mild nucleoprotein Older Patient pediatric percentage percentages positive presenting Prevalence protocol protocols SARS-CoV-2 serology Seropositivity Seroprevalence serum/plasma severe acute respiratory syndrome Coronavirus significantly lower St. Louis tested USA were infected [DOI] 10.1128/mSphere.01207-20 PMC 바로가기 [Article Type] Research Article
Overcoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnosticsSARS-CoV-2 실험실 진단에 사용되는 면봉 시스템 가용성의 한계 극복Article Published on 2021-01-262022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, [키워드] Accuracy caused Combination conducted COVID-19 patients Ct values diagnosis of COVID-19 diagnostic diagnostics Effectiveness Follow-up generate Hospitalized house Imbalance Infectious-disease diagnostics Laboratory laboratory-confirmed limitation pandemic pandemic spread positive result reagent reagents recommendation reflected respiratory respiratory specimen respiratory specimens RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RT-PCR significant difference significant differences significantly lower Spread supply Swab swabs the disease US CDC Viral viral genes viral infection [DOI] 10.1038/s41598-021-81782-8 PMC 바로가기 [Article Type] Article
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study입원한 COVID-19 환자에서 SARS-CoV-2에 대한 항체의 일시적 발달 및 중화 가능성: 관찰 코호트 연구Observational Study Published on 2021-01-262022-09-10 Journal: PLoS ONE [Category] 임상, 진단, 치료기술, 치료법, [키워드] ACE-2 antibody Antibody Response Antibody responses attachment protein best binding clinical presentation Cohort COVID-19 description diagnostic diagnostic testing domain event explain Frame help hospitalised hospitalised COVID-19 patient hospitalised COVID-19 patients house human host Humoral response humoral responses IgG antibodies IgG antibody IgG response IgG responses Infection inhibiting binding neutralising nucleocapsid protein Observational cohort study onset of symptoms outcome Patient predictor produced Protective Protein RBD reached receptor respiratory respiratory infection S protein SARS-CoV-2 Seroconversion seroconverting Serological assay serological assays symptom onset Temporal the S protein These data Time frame unit Viral viral respiratory infection Virus neutralisation were used [DOI] 10.1371/journal.pone.0245382 PMC 바로가기 [Article Type] Observational Study
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples열 비활성화 샘플에서 비상업용 RT-LAMP 시약을 사용한 SARS-CoV-2의 직접 검출Article Published on 2021-01-192022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, [키워드] applicability approach compatibility condition contribute COVID-19 diagnostics Direct DNA polymerase Enzymes expansion facilitate heat-inactivated house nasopharyngeal sample Nasopharyngeal samples optimization Patient patients PCR-based techniques produced reagent required reverse transcriptase reverse transcriptases RNA RT-LAMP SARS-CoV-2 SARS-CoV-2 testing shown Spread the disease viral infection [DOI] 10.1038/s41598-020-80352-8 PMC 바로가기 [Article Type] Article
Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Children during Coronavirus Disease 20192019년 코로나바이러스 질병 기간 동안 알레르기성 비염 소아에서 설하 면역요법의 효능Article Published on 2021-01-012022-09-11 Journal: ORL; journal for oto-rhino-laryngology and its rel [Category] 치료기술, [키워드] activity Adverse reaction Adverse reactions allergen allergic rhinitis baseline level baseline levels change children clinical effectiveness coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 different time point different time points disease effective Effectiveness evaluate evaluated family had more had no house House dust House dust mite IgE Immunotherapy medication nasal no significant differences Occurrence recruited reduced reduction restrict rhinitis serum significant differences significantly significantly lower SLIT Sublingual Sublingual immunotherapy Symptom the epidemic Total Total nasal symptoms score. Treatment [DOI] 10.1159/000514157 PMC 바로가기 [Article Type] Article
Home quarantine in COVID-19: A study on 50 consecutive patients in AustriaCOVID-19의 자가격리: 오스트리아에서 50명의 연속 환자에 대한 연구Article Published on 2021-01-012022-09-11 Journal: Clinical medicine (London, England) [Category] 치료기술, [키워드] Ageusia aggravation Anosmia Characteristics Clinical characteristics clinical characteristics, Cohort consecutive patient Corona COVID-19 COVID-19 patient COVID-19 patients discharge East female patient Female patients fluctuation Follow-up follow-up examination headache highlight home home quarantine house index indicated investigation management median outlier Participants predict quarantine recurrences Ribonucleic acid Seroconversion Seven significantly more Specific statistical Stool stool samples Symptoms the disease throat swab throat swabs Viral viral ribonucleic acid viral shedding virus Virus shedding younger patient younger patients [DOI] 10.7861/clinmed.2020-0787 PMC 바로가기 [Article Type] Article
A Computer-Aided Drug Design Approach to Predict Marine Drug-Like Leads for SARS-CoV-2 Main Protease InhibitionSARS-CoV-2 주요 프로테아제 억제를 위한 해양 약물 유사 리드를 예측하기 위한 컴퓨터 지원 약물 설계 접근 방식Article Published on 2020-12-102022-08-31 Journal: Marine Drugs [Category] MERS, SARS, 신약개발, [키워드] Accuracy actinomycetes approach best carried ChEMBL computer-aided drug design COVID-19 pandemic database derivatives drug Drug discovery enzyme FIVE house inhibition inhibitors leads Ligand limit list M pro machine learning (ML) techniques main protease enzyme (Mpro) marine natural products (MNPs) mitigate MNP molecular docking predicted Predictive protease Quantitative quantitative structure–activity relationship quantitative structure–activity relationship (QSAR) resource retrieved SARS-CoV-2 SARS-CoV-2 main protease screened selected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) team training sets Virtual screening virtual screening library [DOI] 10.3390/md18120633 PMC 바로가기 [Article Type] Article
Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey국가 COVID-19 혈청 유병률 조사에 사용하기 위한 SARS-CoV-2 측면 흐름 분석의 임상 및 실험실 평가Article Published on 2020-12-012022-09-11 Journal: Thorax [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI 95%CI Analysis antibody Antibody test antibody tests approach best Blood clinic clinical clinical epidemiology Cohort Community Concordance conducted COVID-19 detectable ELISA ELISAs evaluated Finger prick FIVE highlighting Hospitalised patients house immunoassay individuals Infection Laboratory Lateral lateral flow Lateral flow immunoassays LFIA LFIAs moderate MONITOR National non-hospitalised pandemic Participants PCR-confirmed Phase I positive reported required respiratory respiratory infection reverse transcription PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 pandemic sensitivity Sensitivity analyses sensitivity analysis sera seroprevalence survey serum significantly specificity symptom onset tested the SARS-CoV-2 Viral viral infection was performed were assessed [DOI] 10.1136/thoraxjnl-2020-215732 PMC 바로가기 [Article Type] Article
Natural versus Recombinant Viral Antigens in SARS-CoV-2 Serology: Challenges in Optimizing Laboratory Diagnosis of COVID-19SARS-CoV-2 혈청학에서 천연 바이러스 항원 대 재조합 바이러스 항원: COVID-19에 대한 실험실 진단 최적화의 과제Original Article Published on 2020-11-262022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody Antigen assays asymptomatic patient Brazil challenge choice commercialization control groups COVID-19 COVID-19 diagnosis COVID-19 negative criteria dependent on develop Diagnosis diagnosis of COVID-19 diagnostic ELISA estimation exhibited false-negative false-negatives False-positive false-positives fraction house IgG IgG antibodies in-house ELISA in-house ELISAs infected patient infected patients Infection information International Laboratory laboratory diagnosis natural nucleocapsid protein pandemic Patient performed public health emergency qPCR recombinant Recombinant nucleocapsid protein recombinant proteins SARS-CoV-2 SARS-CoV-2 Whole Viral Antigen sera serological test serology susceptibility the SARS-CoV-2 Viral Viral antigen viral antigens [DOI] 10.6061/clinics/2020/e2290 PMC 바로가기 [Article Type] Original Article
Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosisSARS-CoV-2의 RBD에 대한 IgG 항체 검사는 COVID-19 진단에 충분하고 필요합니다.Research Article Published on 2020-11-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, [키워드] acute phase antibody kinetics COVID 19 patient COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients Critical demonstrated detect develop diagnose diagnostic ELISA exposure to first positive healthy highlight house identify IgA IgA antibodies IgA level IgG antibodies IgG antibody IgG level IgG levels IgM individual Infection MOST PCR RBD Receptor binding domain regulated SARS-CoV-2 serological serum serum sample Seven specificity Spread tested Testing the disease the RBD Travel uninfected [DOI] 10.1371/journal.pone.0241164 PMC 바로가기 [Article Type] Research Article