HD5 and LL-37 Inhibit SARS-CoV and SARS-CoV-2 Binding to Human ACE2 by Molecular SimulationOriginal Research Published on 2021-08-072023-06-15 Journal: Interdisciplinary sciences, computational life sci [Category] MERS, SARS, [키워드] human ACE2 MM-PBSA Molecular simulation SARS-CoV SARS-CoV-2 [DOI] 10.1007/s12539-021-00462-3 PMC 바로가기 [Article Type] Original Research
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2SARS-CoV-2의 출현과 관련된 재조합 및 계통 특이적 돌연변이Research Published on 2021-08-062022-09-10 Journal: Genome Medicine [Category] MERS, SARS, 변종, [키워드] accompanied adaptation affecting affinity Algorithm allele alleles analyses ancestor ancestors Betacoronavirus Betacoronavirus genus binding binding affinity clade event Evidence evidence of hACE2 helix host cell Human human ACE2 humans in silico include indicate infect information insertion interact MERS MERS-CoV Mutation Phylogenetic Protein protein level RBD receptor Receptor binding affinity Receptor binding domain receptors Recombination recombination event reconstruction responsible Result resulting SARS-CoV SARS-CoV-2 sequence significantly Spike protein strain supplementary material the RBD the Spike variant variants Viral virus viruses was used zoonosis zoonotic [DOI] 10.1186/s13073-021-00943-6 PMC 바로가기 [Article Type] Research
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19Research Article Published on 2021-08-032022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Ad5-hACE2 airway epithelia angiotensin-converting enzyme 2 bind Calu-3 camostat Camostat mesylate caused Cell cell line cleaved coronavirus coronavirus disease COVID-19 disease pathogenesis entry of SARS-CoV-2 epithelia exhibiting greater hACE2 host cell human ACE2 in vivo Infection inhibit inhibitors initiate intranasal K18 K18-hACE2 limit lung tissue membrane fusion MERS-CoV mice Middle East Model morbidity and mortality Mortality mouse Mouse models nafamostat pandemic pathogenic coronavirus preclinical drug studies primary human airway Prophylactic protease Protease inhibitor protease TMPRSS2 Protective pulmonary receptor reduced respiratory syndrome coronavirus respiratory tract SARS-CoV-2 SARS-COV-2 infection serine protease serine protease inhibitors significantly Spike protein tested the spike protein TMPRSS2 transgenic mice Treatment viral burden weight loss [DOI] 10.1128/mBio.00970-21 PMC 바로가기 [Article Type] Research Article
Drug repurposing against SARS-CoV-2 receptor binding domain using ensemble-based virtual screening and molecular dynamics simulationsResearch article Published on 2021-08-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 신약개발, [키워드] ACE2 proteins ACE2-RBD acute respiratory syndrome approach binding binding domain binding site caused Clustering analysis conformation conformational Conformational ensemble conformations Coronavirus-2 COVID-19 death docking scores drug drug design Drug repurposing drugs exhibited FDA approved drug help human ACE2 identify inhibiting Interaction investigated MD simulation MD simulations molecular Molecular dynamics simulation plasticity predicted RBD Receptor binding domain Respiratory disease responsible SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor significantly Spike protein stability the RBD the SARS-CoV-2 Virtual screening virus infection were used worldwide pandemic [DOI] 10.1016/j.compbiomed.2021.104634 [Article Type] Research article
SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinitySARS-CoV-2 B.1.1.7 및 B.1.351 스파이크 변이체는 증가된 친화력으로 인간 ACE2에 결합합니다Article Published on 2021-08-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, [키워드] B.1.351 human ACE2 SARS-CoV-2 B.1.1.7 spike variant [DOI] 10.1016/S1473-3099(21)00262-0 PMC 바로가기 [Article Type] Article
Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 InfectionCommunication Published on 2021-07-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 Adenovirus Vector animal model anti-viral immune responses assessment Cellular immune response COVID-19 days post-infection develop Efficacy Evolution expression full recovery HLA HLA transgenic mice Human human ACE2 human ACE2 receptor humoral immune response immunized mice implementation Infection infection with SARS-CoV-2 mice Model Post-infection Protective protocol pulmonary Re-infection reproducibility response SARS-CoV-2 SARS-COV-2 infection spike-protein strain subsequent the disease transgenic mice Transient Variability viral infection virus [DOI] 10.3390/pathogens10080940 PMC 바로가기 [Article Type] Communication
Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19Research Article Published on 2021-07-232022-10-27 Journal: BioMed Research International [Category] COVID-19, SARS, [키워드] ACE2 Analysis Antiviral bind change characterization clinical trial COVID-19 develop disparate Effect Effectiveness enzyme explain glycoprotein HCQ help human ACE2 Hydroxychloroquine in vitro inhibit inhibitor inhibitory action insight Interaction knowledge mechanism MLN-4760 modulation New outcome SARS-CoV SARS-CoV-2 shown similarity the RBD the spike protein viral replication viral spike virus [DOI] 10.1155/2021/6614000 PMC 바로가기 [Article Type] Research Article
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased TransmissibilitySARS-CoV-2 스파이크/인간 ACE2 복합 인터페이스의 구조 모델링은 전파율 증가와 관련된 고친화도 변이를 식별할 수 있습니다.Article Published on 2021-07-232022-09-11 Journal: Journal of Molecular Biology [Category] SARS, 변종, [키워드] ACE2 affinity Analysis antibody antibody resistance Applying binding binding affinities binding affinity changes in circulating Cluster Combination combinatorial mutations complex complexes COVID-19 pandemic determine E484K Effect flexible functional G476S generate hACE2 help human ACE2 human ACE2 receptor Increased Infection Interaction interface Intervention K31 K353 modeling mutant Mutation N501Y pathogenic Point mutation predict predicted Protein Protein binding public health measure Region reveal S477N SARS-CoV-2 SARS-CoV-2 spike protein screening method sequence spike spike mutations Spike protein Structural analysis structural modeling susceptibility susceptibility to infection the SARS-CoV-2 Transmissibility transmissible variants transmissible variants. triggered variant variants Variation viral strains viral variant wild-type [DOI] 10.1016/j.jmb.2021.167051 PMC 바로가기 [Article Type] Article
Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19ACE2 활동에 대한 Hydroxychloroquine의 조절 효과의 특성 : Covid-19와 관련된 새로운 통찰력Research Article Published on 2021-07-232022-09-10 Journal: BioMed Research International [Category] 치료제, [키워드] ACE2 Analysis Antiviral bind change characterization Chloroquine clinical trial clinical trials Coronaviridae COVID-19 develop disparate Effect Effectiveness enzyme explain glycoprotein HCQ help human ACE2 Hydroxychloroquine in vitro inhibit inhibitor inhibitory action insight Interaction knowledge leads mechanism MLN-4760 modulation New no effect outcome potency SARS-CoV SARS-CoV-2 shown similarity specific inhibitor spike glycoprotein Spike protein the RBD the spike protein Viral viral replication viral spike virus viruses [DOI] 10.1155/2021/6614000 PMC 바로가기 [Article Type] Research Article
Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19Research Article Published on 2021-07-232022-10-27 Journal: BioMed Research International [Category] [키워드] ACE2 Analysis Antiviral bind change characterization clinical trial COVID-19 develop disparate Effect Effectiveness enzyme explain glycoprotein HCQ help human ACE2 Hydroxychloroquine in vitro inhibit inhibitor inhibitory action insight Interaction knowledge mechanism MLN-4760 modulation New outcome SARS-CoV SARS-CoV-2 shown similarity the RBD the spike protein viral replication viral spike virus [DOI] 10.1155/2021/6614000 PMC 바로가기 [Article Type] Research Article