innate immune system – Page 12 – Communicable Diseases Research

Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2

Article

Published on 2021-02-192022-10-28
Journal: Pathogens [Category] COVID-19,

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

소아에서 SARS-CoV-2 감염의 급성 및 회복기 동안의 타고난 세포 프로필

Article

Published on 2021-02-172022-09-10
Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단,

[키워드] activated neutrophil Activated neutrophils acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD63 cell profile children circulating classical clinically convalescent convalescent phase coronavirus Course COVID-19 dendritic cell dendritic cells disease immune responses immunological immunological mechanism Immunopathogenesis infected children Infection Infectious diseases Innate innate immune response innate immune system Innate immunity low-density Mild mild SARS-CoV-2 infection monocyte Monocytes natural killer cell Natural killer cells neutrophil Neutrophils non-classical monocyte Non-classical monocytes observé PCR testing proportion reduced respiratory SARS-CoV-2 SARS-COV-2 infection subset
[DOI] 10.1038/s41467-021-21414-x PMC 바로가기 [Article Type] Article

Novel Coronavirus Disease 2019 (COVID-19) and Cytokine Storms for More Effective Treatments from an Inflammatory Pathophysiology

Review

Published on 2021-02-172022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] Abnormalities ACE2 activate acute respiratory distress Administered Against anti-rheumatic drug bat cause caused Cell cell debris Central nervous system chemokine chemokines China chronic inflammation Coagulation COVID-19 cytokine cytokine receptor Cytokine release syndrome Cytokine storm Damage-associated molecular patterns develop disorders Disseminated intravascular coagulation DNA Effect endothelial cell damage Europe excessive inflammatory response Favipiravir G-CSF global pandemic Host human Angiotensin-converting enzyme IL-1β IL-6 IL-8 immune system Infection Infectious disease Inflammatory response inhibit innate immune system Innate immunity involved IP10 liver melatonin mitochondrial mitochondrial dysfunction Mitochondrial function monoclonal antibodies multiple organ failure new virus novel novel coronavirus diseases (or COVID-19) occur organ damage patients producing Proinflammatory cytokine renal respiratory infection resulting SARS-CoV SARS-CoV-2 second serum storm Stress subject subsequent suppress syndrome TNF-α Tocilizumab treatment for COVID-19 Vascular viral invasion
[DOI] 10.3390/jcm10040801 PMC 바로가기 [Article Type] Review

SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges

Review

Published on 2021-02-042022-10-30
Journal: Infectious Disease Reports [Category] COVID-19,

[키워드] ACE2 acute respiratory distress Adaptive immune response angiotensin-converting enzyme 2 Antibody titers Asymptomatic CD147 challenge characterized cleavage CLR Coronavirus disease-19 COVID-19 Cytokine storm syndrome displaying domain dysregulation Effect Frame host immune system immune antagonism Immunopathogenesis immunopathology immunotherapies implicated include innate immune system Interaction life-threatening mechanism myeloid non-structural protein Novel coronavirus NRP1 nucleic acid vaccine opportunity Other pathology peptide Potential receptor reduced Research respiratory SARS-CoV-2 SARS-COV-2 infection spike glycoprotein syndrome Therapeutics Therapies therapy TMPRSS2 Treatment Vaccine Vaccines viral spread Viral variants virus Wuhan, China
[DOI] 10.3390/idr13010013 PMC 바로가기 [Article Type] Review

Can COVID-19 Cause Flare-Ups of Acute Hepatitis B? An Atypical Presentation of COVID-19 with Acute Hepatitis B

Case Report

Published on 2021-02-042022-10-31
Journal: Case Reports in Infectious Diseases [Category] COVID-19,

[키워드] addition Admission ambulance service Ammonium Antigen Apoptosis blood test Brain Can cause caused cell damage chest X-ray Coagulation cough COVID-19 COVID-19 patients creatinine cytotoxic T lymphocyte Department died edema elevated Emergency event febrile Fever fixed hepatitis B hepatocyte Infection initial innate immune system liver Liver damage lung infiltrates lung involvement male Necrosis occurred past medical history Pathogenesis pathophysiological Patient PCR testing positive presentation Pupils SARS-CoV-2 serological test serology Support Swab the patient transaminases urea viral replication X-ray
[DOI] 10.1155/2021/8818678 PMC 바로가기 [Article Type] Case Report

Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data

UK Biobank 데이터에서 유전적 변이가 COVID-19 관련 사망 위험을 증가시키는 것으로 확인되었습니다.

Primary Research

Published on 2021-02-032022-09-10
Journal: Human Genomics [Category] MERS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 associations bronchial epithelial cell cardiovascular disease cardiovascular diseases caused chromosome chromosomes CLUAP1 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality dataset death deaths DES DNAH7 downregulated gene dysfunction ENhance epithelial cells ethnic group Ethnic groups Factors Genetic genetic factors Genetic variant genetic variants Genome-wide association study genome-wide significant GWAS heterogeneous Host Host genetic factors human bronchial epithelial cells identify increased risk infected case infecting innate immune system interactions male mitochondrial mitochondrial dysfunction molecular Mortality pathogenesis of COVID-19 power Replication reported respiratory Result risk factor risk of COVID-19 risk of death SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity significantly SPEG STXBP5 supplementary material susceptibility susceptibility loci the patient therapeutic options thromboembolic thromboembolic disease TOMM7 Traditional UK biobank UK Biobank data variant WSB1
[DOI] 10.1186/s40246-021-00306-7 PMC 바로가기 [Article Type] Primary Research

Complement Activation in Kidneys of Patients With COVID-19

COVID-19 환자의 신장에서 보체 활성화

Immunology

Published on 2021-01-292022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] activated Activation acute kidney failure acute respiratory syndrome affected Alternative pathway analyzed Antigen arteries Arterioles Artery Autopsy basement membrane biopsies biopsy C1q C3c C4d C5b-9 Capillaries capillary Cell classical pathway cleavage clinical setting Coagulation collateral tissue collectin complement Complement activation Complement pathway complement system complement—immunological term complex controls COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients CTRL deregulated develop Disseminated intravascular coagulation dominant Endothelial cell endothelial injury Factor Frequency glomerular hemolytic uremic syndrome highest immune cell responses immune response immunohistochemistry In situ hybridization in some infection with COVID-19 Injury innate immune system intravascular coagulation investigated involved kidney Kidney failure kidneys lectin lectin pathway lectin pathway activation lung marker MASP-2 membrane Most patient Most patients nuclear occur opsonization organ pathway Patient patients with COVID-19 PCNA peritubular peritubular capillaries peritubular capillary plasma Platelet Platelets positive platelets Prevent proliferation Protein protocol renal renal arteries renal tissue respiratory SARS-CoV-2 Severe acute respiratory syndrome specimen specimens subsequent therapy Thrombus thrombus formation tissue tissue injury Transplant Treatment triggering uremic syndrome virus viruses with COVID-19 worsening
[DOI] 10.3389/fimmu.2020.594849 PMC 바로가기 [Article Type] Immunology

Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice

혈청 아밀로이드 P는 생쥐에서 단일 가닥 RNA 유발 폐 염증, 폐 손상 및 사이토카인 폭풍을 억제합니다

Research Article

Published on 2021-01-222022-09-10
Journal: PLoS ONE [Category] 치료법,

[키워드] accumulation aggregate alveolar amyloid animal model animal models aspiration Blood clots cause clinical trials clot COVID-19 cytokine Cytokine storm D-dimer D-dimer level D-dimer levels disease Efficacy Extracellular female fibrosis Genome Hyperactivation IL-12p70 IL-1β IL-23 IL-27 IL-6 immune increase in induce Infection inflammatory cell inflammatory cells Inflammatory cytokine Inflammatory cytokines inflammatory immune cells inhibit innate immune system intraperitoneal injection Intraperitoneal injections lung lung alveolar lung damage Lung inflammation male mice mononuclear cells Peripheral blood Protein reduced RNA SARS-CoV-2 sequence serum serum amyloid serum cytokine serum cytokine levels Serum protein severe COVID-19 symptom severe symptom ssRNA Symptom Symptoms therapeutic upregulation virus women
[DOI] 10.1371/journal.pone.0245924 PMC 바로가기 [Article Type] Research Article

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

Review

Published on 2021-01-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Anti-viral immunity c-lectin type receptor Can carbohydrate catastrophic Cell CLR CLRs contribute coronavirus disease Coronavirus-2 COVD-19 COVID-19 demonstrated Dipeptidyl peptidase-4 engage ezrin Glucose glucose-regulated protein 78 glycosylated glycosylation GRP78 Health host cell immune immunopathological independent Infection Inflammation innate immune system Interaction mannose receptor Multiple N-glycans non-immune NRP1 Occurrence Protein receptor Recognition regulated reported responsible S protein SARS-CoV-2 SARS-CoV-2 S protein Spike protein Spread susceptibility the S protein therapeutic target TLR TLRs Toll-like receptor viral clearance viral surface
[DOI] 10.3390/ijms22030992 PMC 바로가기 [Article Type] Review

Observations on the use of Bruton’s tyrosine kinase inhibitors in SAR-CoV-2 and cancer

SAR-CoV-2 및 암에서 Bruton의 티로신 키나제 억제제 사용에 대한 관찰

Letter to the Editor

Published on 2021-01-132022-09-10
Journal: Journal of Hematology & Oncology [Category] 신약개발, 유전자 메커니즘,

[키워드] Acalabrutinib acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Bruton’s tyrosine kinase BTK BTK inhibitor Cancer circulation Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients Cytokines determine drug Ibrutinib IL-1β infected with SARS-CoV-2 inhibitors innate immune system Lung disease Lung injury observation Patient potential mechanism pro-inflammatory cytokine pro-inflammatory cytokines PROTECT pulmonary injury respiratory SAR-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus tyrosine tyrosine kinase inhibitor understanding
[DOI] 10.1186/s13045-020-00999-8 PMC 바로가기 [Article Type] Letter to the Editor