Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A ReviewPathology Published on 2024-03-262024-09-05 Journal: Cureus [Category] update2024, [키워드] Cytokine storm innate immune system public awareness about vaccination spike protein and covid-19 type-1 interferons [DOI] 10.7759/cureus.57008 PMC 바로가기 [Article Type] Pathology
Response of the mosquito immune system and symbiotic bacteria to pathogen infectionArticle Published on 2024-02-172024-08-29 Journal: Parasites & Vectors [Category] 말라리아, [키워드] immune priming innate immune system Mosquito pathogen infection Symbiotic bacteria.
Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signalsReview article Published on 2022-10-012022-10-05 Journal: Sleep medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Activation addition adverse event Compliance Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Critical disease manifestation global healthcare Healthcare professional Hypothesis IL-1β Immunity IMPROVE INF-γ Inflammatory inflammatory signal inhibit innate immune system interactions knowledge mechanism morbidity and mortality Narcolepsy Neuron occur Orexin physiological pro-inflammatory cytokine reactogenic reactogenicity Regulation reported Research SARS-COV-2 infection Sickness Side effect Sleep Sleep disturbance Symptom TNF-α vaccination Vaccine while [DOI] 10.1016/j.sleep.2022.06.011 [Article Type] Review article
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 InfectionArticle Published on 2022-10-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation Vaccine vaccine candidate vaccine candidates vaccine for COVID-19 viral disease viral evolution virus viruses [DOI] 10.1007/s10753-022-01651-y PMC 바로가기
Canakinumab in patients with COVID-19 and type 2 diabetes – A multicentre, randomised, double-blind, placebo-controlled trialArticle Published on 2022-09-172022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] 1:1 95 % CI Activation addition Administered adverse event approach assigned Basel blockade BMI canakinumab Clinical outcome contributing to COVID-19 CRP Dexamethasone diabetes died dose double-blind dropped drug Efficacy foundation glycaemic control higher risk hospitalised Hospitalization Hyperinflammatory ICU IL-1beta IL-1β IL-6 IMPROVE Inflammasome innate immune system interleukin-1β intravenous dose less medication multicenter multicentre Novartis Obesitiy. obesity outcome participant Patient patients treated patients with COVID-19 Placebo placebo group placebo-controlled trial primary analysis randomised randomization Randomly reduction Registered reported required SARS-CoV2 SARS-CoV2 infection Science Seven severe COVID-19 significantly Standard-of-care statistically significant statistically significant difference survival Switzerland systemic inflammation tested treated Treatment type 2 diabete university Ventilation with COVID-19 [DOI] 10.1016/j.eclinm.2022.101649 PMC 바로가기 [Article Type] Article
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohortArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C Multisystem inflammatory syndrome Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined [DOI] 10.3389/fimmu.2022.992022 PMC 바로가기
The intersection molecule MDA5 in Cancer and COVID-19Article Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] anti-tumor immunity antiviral response Autoimmune diseases cancer cell cGAS-STING connection COVID-19 cytoplasmic damaged dead Defense dsRNA evade function Host IFN immunomodulatory factor induce Inflammatory cytokines innate immune responses innate immune system interferon Intersection MDA5 mechanism Melanoma nucleic acid PAMPs pathogen-associated molecular pattern pattern recognition receptor Pattern recognition receptors pattern recognition receptors. PRRs recognizing RNA SARS-CoV-2 SARS-CoV-2 virus infection signaling pathway subsequent Trigger triggering Viral RNA virus [DOI] 10.3389/fimmu.2022.963051 PMC 바로가기
On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화Article Published on 2022-08-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus [DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article
Flipped Inflammatory Time and the Role of Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: Optimizing Tocilizumab Against Coronavirus Disease 2019뒤집힌 염증 시간과 중증 급성 호흡기 증후군에 대한 항체의 역할 코로나바이러스 2: 코로나바이러스 질병 2019에 대한 토실리주맙 최적화Article Published on 2022-08-122022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Against Anti-inflammatory effects autoantibodies benefit Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 disease dose driven by highest IL-6 IL-6 inhibition IL-6 inhibitor IL-6 inhibitors Immunopathogenesis inhibitor inhibitors innate immune system interferon interleukin mechanism of action modulate Mortality Open-label Patient Platform trial predict proinflammatory question Randomized respiratory risk role SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconvert serostatus severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein subgroup of patient therapy time Tocilizumab Treatment [DOI] 10.1093/infdis/jiac090 PMC 바로가기 [Article Type] Article