SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responsesMHC-I 제한 에피토프의 SARS-CoV-2 돌연변이는 CD8 + T 세포 반응을 회피합니다Research Articles Published on 2021-03-042022-09-10 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, [키워드] abrogated binding CD8 Cell COVID-19 patient COVID-19 patients COVID-19 severity CTL cytotoxic activity deep sequencing epitope Epitopes evade Ex vivo exhibited highlight IFN-γ Immunity implicated in vitro isolates MHC-I MHC-I epitope MHC-I epitopes mutant nonsynonymous mutation Nonsynonymous mutations peptide peptides Point mutation point mutations proliferation response RNA sequencing SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 virus Sequencing Surveillance T cell T cell epitope T cell epitopes T cells tetramer transcriptional response Viral virus [DOI] 10.1126/sciimmunol.abg6461 PMC 바로가기 [Article Type] Research Articles
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2SARS-CoV-2의 스파이크 당단백질 구조에 대한 D614G 치환 효과423 Published on 2021-03-022022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding circulating conformation coronavirus cryo Cryo-electron microscopy cryo-EM D614G D614G substitution electron microscopy facilitate High-resolution initial isolate isolates majority membrane fusion mutant open opening priming promote reason reason for receptor receptor ACE2 reported required respiratory SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus Significance spike spike glycoprotein spike glycoproteins Spike protein Spike proteins spikes structural rearrangement Structure subsequent suggested the SARS-CoV-2 the spike protein variant Viral viral membrane virus virus infectivity viruses [DOI] 10.1073/pnas.2022586118 PMC 바로가기 [Article Type] 423
Geographical reconstruction of the SARS-CoV-2 outbreak in Lombardy (Italy) during the early phase초기 단계 동안 롬바르디아(이탈리아)에서 SARS-CoV-2 발생의 지리적 재구성Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] aligned Analysis Bergamo Brescia Characteristics circulation clade clades clinical CLOCK Cluster Complete conducted country COVID-19 case COVID-19 cases early phase Epidemic epidemiological epidemiological surveillance full length Genetic genetic variability Genome genomic sequence GISAID database highest highlight hospital Hypothesis initial involved isolate isolates Italian Italy lombardy M gene male mapped Microbiology molecular Mutation outbreak Pandemics Patient patient identification Phylogenetic Phylogenetic analysis Pneumonia positive prevalence of COVID-19 reported SARS Coronavirus SARS-CoV-2 strain Spread Surveillance the SARS-CoV-2 transmission of SARS-CoV-2 Viral genome assembly Virology virus [DOI] 10.1002/jmv.26447 PMC 바로가기 [Article Type] Article
Hospitalization and mortality associated with SARS-CoV-2 viral clades in COVID-19COVID-19의 SARS-CoV-2 바이러스 계통군과 관련된 입원 및 사망률Article Published on 2021-02-262022-09-10 Journal: Scientific Reports [Category] MERS, 변종, [키워드] age applied AUC baseline circulation clade clades Clinical characteristics Clinical outcome co-morbidities co-morbidity collected comorbid conditions Complication COVID-19 COVID-19 epidemic COVID-19 patient death demographic Demographic and baseline clinical characteristics demographics demonstrated determine died dominant Genes Genetic variant Genome health system Hospitalization Hospitalized IMPROVE include individual Infection isolate isolates machine machine learning machine learning model machine learning models Major medical system Medicine morbidities Mortality Mutation no significant difference Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide outcome Outcomes research Pathogens Patient patient age polymorphism Registered risk factor SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 viral sequence sequence information significantly Single nucleotide variant subject Translational research University of Washington variant Viral viral clade viral clades Virology virus was obtained Washington [DOI] 10.1038/s41598-021-82850-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak베네수엘라의 SARS-CoV-2 유전적 다양성: D614G 변이의 우세 및 한 발병 분석Research Article Published on 2021-02-192022-09-10 Journal: PLoS ONE [Category] MERS, 변종, 치료기술, [키워드] Amino acid amino acids Analysis circulating Complete coronavirus COVID-19 COVID-19 disease D614G mutation D614G variant Deletion deletions Frame Frequency Genetic genetic diversity Genome genomic highest in-frame deletion island isolate isolates Lineage Margarita N-terminal domain New coronavirus nsp1 occurred ORF1 outbreak Patient Protein Region regions responsible Sanger sequencing SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolate SARS-CoV-2 isolates sequence Spike protein strain Structural analysis the epidemic the Spike Venezuela whole genome [DOI] 10.1371/journal.pone.0247196 PMC 바로가기 [Article Type] Research Article
SARS-Cov-2 ORF3a: Mutability and functionSARS-Cov-2 ORF3a: 변경 가능성 및 기능Article Published on 2021-02-152022-09-11 Journal: International journal of biological macromolecules [Category] 변종, [키워드] Analysis cellular components change conserved Conserved sites Contact contact with coronavirus coronavirus protein data set dimer domain examined FIVE Genome GISAID Interaction interval involved isolates monomer mutant Mutated sites Mutation occur ORF3a ORF3a protein pandemic Pore Q57H reported SARS-CoV-2 SARS-CoV-2 genome Therapeutic strategies transmembrane variant virus virus genome virus genomes virus replication [DOI] 10.1016/j.ijbiomac.2020.12.142 PMC 바로가기 [Article Type] Article
Coding-Complete Genome Sequences of NITMA1086 and NITMA1139, Two SARS-CoV-2 Isolates from Belagavi District, Karnataka State, India, Harboring the D614G MutationGenome Sequences Published on 2021-02-112022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome Analysis coronavirus coronavirus disease D614G D614G substitution District genome sequence India isolate isolates nasopharyngeal swabs RNA SARS-CoV-2 sequence state [DOI] 10.1128/MRA.00016-21 PMC 바로가기 [Article Type] Genome Sequences
Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell culturesArticle Published on 2021-02-102022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] appear both virus Cell Cell culture complement COVID-19 disease Culture electron tomography Epidemiology Frankfurt globe infancy information isolates median Microscopy morphology particle size distribution SARS virus SARS-CoV SARS-CoV-2 SARS-CoV-2 particle spike spikes Spread the disease the SARS-CoV-2 Treatment Ultrastructural analysis Vero Cell virus was related while [DOI] 10.1038/s41598-021-82852-7 PMC 바로가기 [Article Type] Article
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh방글라데시에서 병원체의 근원과 다양성을 결정하기 위한 SARS-CoV-2의 in silico 비교 게놈Research Article Published on 2021-01-202022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] affected Analysis caused China Clusters coding region Comparative analysis conducted country COVID19 D614G determine epidemiological France Genome genomic variation genomic variations indicated isolate isolates leads Missense Missense mutation Missense mutations Mutation NSP2 pandemic pathogen Phylogenetic analysis predict predicted prevalent Protein protein structures reported SARS-CoV-2 SARS-CoV-2 genomic sequences SARS-CoV-2 isolate SARS-CoV-2 sequence SARS-CoV-2 virus Saudi Arabia Spike protein strain Strains structures the spike protein transmission route United Kingdom virus viruses Whole-genome sequence whole-genome sequences [DOI] 10.1371/journal.pone.0245584 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia필라델피아 입원 환자의 공간 및 시간에 따른 SARS-CoV-2 게놈 변이Research Article Published on 2021-01-192022-09-10 Journal: mBio [Category] 변종, 유전자 메커니즘, 치료기술, [키워드] accelerated accumulation B.1 circulating city clade collected comparison coronavirus COVID-19 Critical D614G substitution disease Epidemic First wave followed by Genome genome sequence Genome sequences Genome sequencing GISAID hospitalized patient hospitalized patients infected individual infected individuals Infection initial isolate isolates Lineage lineages midsummer Multiple New York Nextstrain outbreak outcome patients Philadelphia polymorphism Polymorphisms respiratory Respiratory Coronavirus SARS-CoV-2 SARS-COV-2 infection sequence sequences Sequencing severe acute respiratory coronavirus Space Spread spring the epidemic time Transmission understanding variant Viral viral spike [DOI] 10.1128/mBio.03456-20 PMC 바로가기 [Article Type] Research Article