Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19Review article Published on 2021-09-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, [키워드] animal models Betacoronavirus Committee competitive binding controls correlated COVID-19 death Diseases distribution Efficacy H. pylori indicated Infectious disease Ivermectin mechanism Medicine Meta-analysis morbidity Mortality Mutant strains notable Physiology randomized clinical trial RCT RCTs reduction reductions in risk SARS-CoV-2 SARS-CoV-2 spike protein Seven Sharp Spike protein Treatment tropical yielding [DOI] 10.1016/j.nmni.2021.100924 [Article Type] Review article
Recent advances in management of COVID-19: A reviewReview Published on 2021-08-272023-06-16 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, [키워드] LPS, Lipopolysaccharides MERS, Middle East Respiratory Syndrome 1KD, Equilibrium dissociation constant (binding affinity) ADE, Antibody dependant enhancement of the disease ARDS, acute respiratory distress syndrome CDC, Centers for Disease Control and Prevention CoV, coronavirus COVID-19 COVID-19, coronavirus disease-2019 CVT, Cerebral Venous Thrombosis Dexamethasone EC50, half maximum neutralization concentration EUA, Emergency Use Authorization Famotidine FDA, Food and Drug Administration Fluoxetine fluvoxamine IC50, Half maximal inhibitory concentration IC90, Concentration that inhibits 90% of the virions ICU, Intensive care unit IL-6, interleukin 6 IMP, importin IRE1, Inositol-requiring enzyme Ivermectin melatonin monoclonal antibodies nanobodies Nbs, Nanobodies NEJM, The New England Journal of Medicine NIH, National Institutes of Health NOS, Reactive nitrogen species OTC, Over the Counter medication PCR, polymerase chain reaction RBD, receptor binding domain RdRp, RNA-dependent RNA polymerase Remdesivir ROS, reactive oxygen species S1R, Sigma 1 receptor SARS-CoV-2 SARS-CoV-2, Severe Acute Respiratory Syndrome Corona Virus 2 SARS, Severe acute respiratory syndrome sdNbs, Single domain nanobodies Serotonin SPR, surface plasmon resonance SSRI TMPRSS2, Transmembrane serine protease 2 TNF-alpha, Tumor Necrosis Factor alpha Tocilizumab WHO, World Health Organization [DOI] 10.1016/j.biopha.2021.112107 PMC 바로가기 [Article Type] Review
Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort StudyPreventive Medicine Published on 2021-08-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 1:1 95% CI active against acute respiratory syndrome adhere applied assigned carried compassionate use Consensus control group coronavirus coronavirus disease COVID-19 COVID-19 prevention COVID-19 test died dose evaluate facilitate Follow-up healthcare personnel healthcare worker Hospitalization ICU Infection intensive care unit Ivermectin ivermectin group matching material offer outcome polymerase chain positive pre-exposure prophylaxis PrEP Previous studies Prophylaxis Randomized controlled trial required retrospective cohort reverse transcription risk reduction RT-PCR SARS-CoV-2 Science score secondary shown sick SPSS Statistical Package symptomatic SARS-CoV-2 infection [DOI] 10.7759/cureus.17455 PMC 바로가기 [Article Type] Preventive Medicine
Corrigendum to Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial [EClinicalMedicine 37 (2021) 100,959]”Erratum Published on 2021-08-262022-10-05 Journal: EClinicalMedicine [Category] 치료제, [키워드] High-dose Ivermectin randomized trial [DOI] 10.1016/j.eclinm.2021.101119 [Article Type] Erratum
Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare WorkersPreventive Medicine Published on 2021-08-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome adjusted relative risk adverse events Care Chemoprophylaxis cohort study conducted coronavirus coronavirus 2 coronavirus disease COVID COVID-19 COVID-19 infection criteria diagnosed dose effective follow-up time Government of India HCW HCWs healthcare services healthcare worker Healthcare workers in vitro study India Infection investigated Ivermectin Kaplan-Meier lower risk maintain male Medical Science Mild pandemic participant participated polymerase chain Preventing Primary outcome Probability Prophylactic Prophylaxis prospective cohort study provided real-time reverse transcriptase reduced reported respiratory Result risk risk of COVID-19 risk reduction role SARS-CoV-2 SARS-COV-2 infection significantly lower single dose Symptom therapeutic Vaccine was used worker [DOI] 10.7759/cureus.16897 PMC 바로가기 [Article Type] Preventive Medicine
Antiviral Effects of Ivermectin in COVID-19- Clinically Plausible?COVID-19에서 Ivermectin의 항바이러스 효과 - 임상적으로 그럴듯합니까?Comment Published on 2021-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] Coronavirus, SARS, 치료제, [키워드] Abstract COVID-19 COVID-19, Ivermectin, Anti-viral effect. Effect Ivermectin [DOI] 10.1016/j.ijid.2021.06.048 PMC 바로가기 [Article Type] Comment
CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapyCovitris2020 및 Chlovid2020 : Covid-19 치료에서 놀라운 새로운 희망Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-COVID-19 drug anti-SARS-CoV-2 antioxidant binding affinities binding affinity binding energy biological assay blocker ChloViD2020 Clinical studies Compound Coronaviral Coronaviral-2 coronavirus COVID-19 COVID-19 therapy CoViTris2020 derivative disease docked docking drug Drug discovery effective enzyme exhibited Favipiravir in vitro inhibit inhibit SARS-CoV-2 inhibitory Ivermectin lead life cycle Ligand lower binding energy medication molecular docking oxadiazole Papain Papain-like protease Papain-like protease (PLpro) PLPro Polyphenolic 2,5-disubstituted-1,3,4-oxadiazole protease Protein RdRP Remdesivir repurposing required Research respiratory RNA polymerase RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) robust SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy [DOI] 10.1007/s11030-020-10169-0 PMC 바로가기 [Article Type] Article
Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection렘데시비르와 이버멕틴의 병용 치료는 쥐 코로나바이러스 감염에 대해 높은 시너지 효과와 강력한 항바이러스 활성을 나타냅니다.Cellular and Infection Microbiology Published on 2021-07-302022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Against antiviral drug antiviral therapy Betacoronavirus Betacoronavirus genus both viruses Cell Chloroquine clinical clinical trial clinical trials Combination combination therapy combination treatment coronavirus COVID-19 COVID-19 pandemic cytokine level develop doxycycline drug drug therapy effective Efficacy evaluated exhibited Hepatitis highest IC50 IL-6 in vitro model in vivo experiment indicated infect Infection inhibitory investigated Ivermectin ivermectin treatment leukemia Live virus lowest Macrophage macrophages mechanism MHV mice monotherapy murine hepatitis virus potent RAW264.7 macrophage cells reduction Remdesivir Replication Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections selectivity index sequence identity significant reductions synergism synergistic tested the Betacoronavirus the disease therapy TNF-α Treatment Trial urgency viability Viral Viral RNA virus viruses [DOI] 10.3389/fcimb.2021.700502 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A secondary approach with conventional medicines and supplements to recuperate current COVID-19 statusReview Published on 2021-07-272023-06-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, [키워드] COVID-19 doxycycline Ivermectin Vitamin-C Vitamin-D Zinc [DOI] 10.1016/j.biopha.2021.111956 PMC 바로가기 [Article Type] Review
Effect of Infodemic Regarding the Illegal Sale of Medications on the Internet: Evaluation of Demand and Online Availability of Ivermectin during the COVID-19 PandemicArticle Published on 2021-07-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] aligned Confusion connection consequence consumer coronavirus COVID-19 COVID-19 pandemic Demand Effect evaluate Evidence Google illegal online pharmacies indication infodemic Ivermectin majority methodology misinformation offered patient safety peaked Pharmacy representing SARS-CoV-2 Self-medication website [DOI] 10.3390/ijerph18147475 PMC 바로가기 [Article Type] Article